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Items: 1 to 20 of 104

1.

Rab5 GTPases are required for optimal TORC2 function.

Locke MN, Thorner J.

J Cell Biol. 2019 Mar 4;218(3):961-976. doi: 10.1083/jcb.201807154. Epub 2018 Dec 21.

PMID:
30578283
2.

Vps9 family protein Muk1 is the second Rab5 guanosine nucleotide exchange factor in budding yeast.

Paulsel AL, Merz AJ, Nickerson DP.

J Biol Chem. 2013 Jun 21;288(25):18162-71. doi: 10.1074/jbc.M113.457069. Epub 2013 Apr 23.

3.

The Stress-Sensing TORC2 Complex Activates Yeast AGC-Family Protein Kinase Ypk1 at Multiple Novel Sites.

Leskoske KL, Roelants FM, Marshall MNM, Hill JM, Thorner J.

Genetics. 2017 Sep;207(1):179-195. doi: 10.1534/genetics.117.1124. Epub 2017 Jul 24.

4.

Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae.

Roelants FM, Breslow DK, Muir A, Weissman JS, Thorner J.

Proc Natl Acad Sci U S A. 2011 Nov 29;108(48):19222-7. doi: 10.1073/pnas.1116948108. Epub 2011 Nov 11.

5.

Plasma membrane recruitment and activation of the AGC kinase Ypk1 is mediated by target of rapamycin complex 2 (TORC2) and its effector proteins Slm1 and Slm2.

Niles BJ, Mogri H, Hill A, Vlahakis A, Powers T.

Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1536-41. doi: 10.1073/pnas.1117563109. Epub 2012 Jan 17.

6.

The TORC2-Dependent Signaling Network in the Yeast Saccharomyces cerevisiae.

Roelants FM, Leskoske KL, Martinez Marshall MN, Locke MN, Thorner J.

Biomolecules. 2017 Sep 5;7(3). pii: E66. doi: 10.3390/biom7030066. Review.

8.

Target of rapamycin complex 2-dependent phosphorylation of the coat protein Pan1 by Akl1 controls endocytosis dynamics in Saccharomyces cerevisiae.

Bourgoint C, Rispal D, Berti M, Filipuzzi I, Helliwell SB, Prouteau M, Loewith R.

J Biol Chem. 2018 Aug 3;293(31):12043-12053. doi: 10.1074/jbc.RA117.001615. Epub 2018 Jun 12.

9.

Phosphorylation by the stress-activated MAPK Slt2 down-regulates the yeast TOR complex 2.

Leskoske KL, Roelants FM, Emmerstorfer-Augustin A, Augustin CM, Si EP, Hill JM, Thorner J.

Genes Dev. 2018 Dec 1;32(23-24):1576-1590. doi: 10.1101/gad.318709.118. Epub 2018 Nov 26.

10.

Ubiquitin binding by the CUE domain promotes endosomal localization of the Rab5 GEF Vps9.

Shideler T, Nickerson DP, Merz AJ, Odorizzi G.

Mol Biol Cell. 2015 Apr 1;26(7):1345-56. doi: 10.1091/mbc.E14-06-1156. Epub 2015 Feb 11.

11.

Sphingolipid biosynthesis upregulation by TOR complex 2-Ypk1 signaling during yeast adaptive response to acetic acid stress.

Guerreiro JF, Muir A, Ramachandran S, Thorner J, Sá-Correia I.

Biochem J. 2016 Dec 1;473(23):4311-4325. Epub 2016 Sep 26.

12.

Rab5-family guanine nucleotide exchange factors bind retromer and promote its recruitment to endosomes.

Bean BD, Davey M, Snider J, Jessulat M, Deineko V, Tinney M, Stagljar I, Babu M, Conibear E.

Mol Biol Cell. 2015 Mar 15;26(6):1119-28. doi: 10.1091/mbc.E14-08-1281. Epub 2015 Jan 21. Erratum in: Mol Biol Cell. 2015 Apr 1;26(7):1411.

13.

Identification of a Rab GTPase-activating protein cascade that controls recycling of the Rab5 GTPase Vps21 from the vacuole.

Rana M, Lachmann J, Ungermann C.

Mol Biol Cell. 2015 Jul 1;26(13):2535-49. doi: 10.1091/mbc.E15-02-0062. Epub 2015 May 13.

14.

Termination of isoform-selective Vps21/Rab5 signaling at endolysosomal organelles by Msb3/Gyp3.

Nickerson DP, Russell MRG, Lo SY, Chapin HC, Milnes J, Merz AJ.

Traffic. 2012 Oct;13(10):1411-1428. doi: 10.1111/j.1600-0854.2012.01390.x. Epub 2012 Aug 5.

15.

TOR Complex 2-Regulated Protein Kinase Fpk1 Stimulates Endocytosis via Inhibition of Ark1/Prk1-Related Protein Kinase Akl1 in Saccharomyces cerevisiae.

Roelants FM, Leskoske KL, Pedersen RTA, Muir A, Liu JM, Finnigan GC, Thorner J.

Mol Cell Biol. 2017 Mar 17;37(7). pii: e00627-16. doi: 10.1128/MCB.00627-16. Print 2017 Apr 1.

16.

Ypk1 and Ypk2 kinases maintain Rho1 at the plasma membrane by flippase-dependent lipid remodeling after membrane stresses.

Hatakeyama R, Kono K, Yoshida S.

J Cell Sci. 2017 Mar 15;130(6):1169-1178. doi: 10.1242/jcs.198382. Epub 2017 Feb 6.

17.

TORC2-dependent protein kinase Ypk1 phosphorylates ceramide synthase to stimulate synthesis of complex sphingolipids.

Muir A, Ramachandran S, Roelants FM, Timmons G, Thorner J.

Elife. 2014 Oct 3;3. doi: 10.7554/eLife.03779.

18.

Regulation of Rab5 isoforms by transcriptional and post-transcriptional mechanisms in yeast.

Schmidt O, Weyer Y, Fink MJ, Müller M, Weys S, Bindreither M, Teis D.

FEBS Lett. 2017 Sep;591(18):2803-2815. doi: 10.1002/1873-3468.12785. Epub 2017 Aug 24.

19.

TOR complex 2-Ypk1 signaling regulates actin polarization via reactive oxygen species.

Niles BJ, Powers T.

Mol Biol Cell. 2014 Dec 1;25(24):3962-72. doi: 10.1091/mbc.E14-06-1122. Epub 2014 Sep 24.

20.

Heterologous mammalian Akt disrupts plasma membrane homeostasis by taking over TORC2 signaling in Saccharomyces cerevisiae.

Rodríguez-Escudero I, Fernández-Acero T, Cid VJ, Molina M.

Sci Rep. 2018 May 16;8(1):7732. doi: 10.1038/s41598-018-25717-w.

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