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Items: 1 to 20 of 111

1.

Downsizing the molecular spring of the giant protein titin reveals that skeletal muscle titin determines passive stiffness and drives longitudinal hypertrophy.

Brynnel A, Hernandez Y, Kiss B, Lindqvist J, Adler M, Kolb J, van der Pijl R, Gohlke J, Strom J, Smith J, Ottenheijm C, Granzier HL.

Elife. 2018 Dec 19;7. pii: e40532. doi: 10.7554/eLife.40532.

2.

Gigantic variety: expression patterns of titin isoforms in striated muscles and consequences for myofibrillar passive stiffness.

Neagoe C, Opitz CA, Makarenko I, Linke WA.

J Muscle Res Cell Motil. 2003;24(2-3):175-89.

PMID:
14609029
3.
4.

Deleting titin's I-band/A-band junction reveals critical roles for titin in biomechanical sensing and cardiac function.

Granzier HL, Hutchinson KR, Tonino P, Methawasin M, Li FW, Slater RE, Bull MM, Saripalli C, Pappas CT, Gregorio CC, Smith JE 3rd.

Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):14589-94. doi: 10.1073/pnas.1411493111. Epub 2014 Sep 22.

5.
6.

Mechanical properties of titin isoforms.

Granzier H, Helmes M, Cazorla O, McNabb M, Labeit D, Wu Y, Yamasaki R, Redkar A, Kellermayer M, Labeit S, Trombitás K.

Adv Exp Med Biol. 2000;481:283-300; discussion 300-4.

PMID:
10987079
7.
8.

Physiological functions of the giant elastic protein titin in mammalian striated muscle.

Fukuda N, Granzier HL, Ishiwata S, Kurihara S.

J Physiol Sci. 2008 Jun;58(3):151-9. doi: 10.2170/physiolsci.RV005408. Epub 2008 May 15. Review.

PMID:
18477421
9.

Titin stiffness modifies the force-generating region of muscle sarcomeres.

Li Y, Lang P, Linke WA.

Sci Rep. 2016 Apr 15;6:24492. doi: 10.1038/srep24492.

10.

Truncation of titin's elastic PEVK region leads to cardiomyopathy with diastolic dysfunction.

Granzier HL, Radke MH, Peng J, Westermann D, Nelson OL, Rost K, King NM, Yu Q, Tschöpe C, McNabb M, Larson DF, Labeit S, Gotthardt M.

Circ Res. 2009 Sep 11;105(6):557-64. doi: 10.1161/CIRCRESAHA.109.200964. Epub 2009 Aug 13.

11.

Removal of immunoglobulin-like domains from titin's spring segment alters titin splicing in mouse skeletal muscle and causes myopathy.

Buck D, Smith JE 3rd, Chung CS, Ono Y, Sorimachi H, Labeit S, Granzier HL.

J Gen Physiol. 2014 Feb;143(2):215-30. doi: 10.1085/jgp.201311129.

12.

Titin (visco-) elasticity in skeletal muscle myofibrils.

Herzog JA, Leonard TR, Jinha A, Herzog W.

Mol Cell Biomech. 2014 Mar;11(1):1-17.

PMID:
25330621
13.

Titin-based tension in the cardiac sarcomere: molecular origin and physiological adaptations.

Anderson BR, Granzier HL.

Prog Biophys Mol Biol. 2012 Oct-Nov;110(2-3):204-17. doi: 10.1016/j.pbiomolbio.2012.08.003. Epub 2012 Aug 11. Review.

14.

Towards a molecular understanding of the elasticity of titin.

Linke WA, Ivemeyer M, Olivieri N, Kolmerer B, Rüegg JC, Labeit S.

J Mol Biol. 1996 Aug 9;261(1):62-71.

PMID:
8760502
15.

Structure-function relations of the giant elastic protein titin in striated and smooth muscle cells.

Granzier H, Labeit S.

Muscle Nerve. 2007 Dec;36(6):740-55. Review.

PMID:
17763461
16.

The role of titin in eccentric muscle contraction.

Herzog W.

J Exp Biol. 2014 Aug 15;217(Pt 16):2825-33. doi: 10.1242/jeb.099127.

17.

What makes skeletal muscle striated? Discoveries in the endosarcomeric and exosarcomeric cytoskeleton.

Rall JA.

Adv Physiol Educ. 2018 Dec 1;42(4):672-684. doi: 10.1152/advan.00152.2018.

18.

Limits of titin extension in single cardiac myofibrils.

Linke WA, Bartoo ML, Ivemeyer M, Pollack GH.

J Muscle Res Cell Motil. 1996 Aug;17(4):425-38.

PMID:
8884598
19.

Differences in titin segmental elongation between passive and active stretch in skeletal muscle.

DuVall MM, Jinha A, Schappacher-Tilp G, Leonard TR, Herzog W.

J Exp Biol. 2017 Dec 1;220(Pt 23):4418-4425. doi: 10.1242/jeb.160762. Epub 2017 Oct 2.

20.

PKC phosphorylation of titin's PEVK element: a novel and conserved pathway for modulating myocardial stiffness.

Hidalgo C, Hudson B, Bogomolovas J, Zhu Y, Anderson B, Greaser M, Labeit S, Granzier H.

Circ Res. 2009 Sep 25;105(7):631-8, 17 p following 638. doi: 10.1161/CIRCRESAHA.109.198465. Epub 2009 Aug 13.

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