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Items: 1 to 20 of 111

1.

Nociceptor Translational Profiling Reveals the Ragulator-Rag GTPase Complex as a Critical Generator of Neuropathic Pain.

Megat S, Ray PR, Moy JK, Lou TF, Barragán-Iglesias P, Li Y, Pradhan G, Wanghzou A, Ahmad A, Burton MD, North RY, Dougherty PM, Khoutorsky A, Sonenberg N, Webster KR, Dussor G, Campbell ZT, Price TJ.

J Neurosci. 2019 Jan 16;39(3):393-411. doi: 10.1523/JNEUROSCI.2661-18.2018. Epub 2018 Nov 20.

PMID:
30459229
2.

The MNK-eIF4E Signaling Axis Contributes to Injury-Induced Nociceptive Plasticity and the Development of Chronic Pain.

Moy JK, Khoutorsky A, Asiedu MN, Black BJ, Kuhn JL, Barragán-Iglesias P, Megat S, Burton MD, Burgos-Vega CC, Melemedjian OK, Boitano S, Vagner J, Gkogkas CG, Pancrazio JJ, Mogil JS, Dussor G, Sonenberg N, Price TJ.

J Neurosci. 2017 Aug 2;37(31):7481-7499. doi: 10.1523/JNEUROSCI.0220-17.2017. Epub 2017 Jul 3.

3.

Signalling to eIF4E in cancer.

Siddiqui N, Sonenberg N.

Biochem Soc Trans. 2015 Oct;43(5):763-72. doi: 10.1042/BST20150126. Review.

4.

Inhibition of mammalian target of rapamycin induces phosphatidylinositol 3-kinase-dependent and Mnk-mediated eukaryotic translation initiation factor 4E phosphorylation.

Wang X, Yue P, Chan CB, Ye K, Ueda T, Watanabe-Fukunaga R, Fukunaga R, Fu H, Khuri FR, Sun SY.

Mol Cell Biol. 2007 Nov;27(21):7405-13. Epub 2007 Aug 27.

5.

MNK1 pathway activity maintains protein synthesis in rapalog-treated gliomas.

Grzmil M, Huber RM, Hess D, Frank S, Hynx D, Moncayo G, Klein D, Merlo A, Hemmings BA.

J Clin Invest. 2014 Feb;124(2):742-54. doi: 10.1172/JCI70198. Epub 2014 Jan 9.

6.

MNK1 inhibitor CGP57380 overcomes mTOR inhibitor-induced activation of eIF4E: the mechanism of synergic killing of human T-ALL cells.

Huang XB, Yang CM, Han QM, Ye XJ, Lei W, Qian WB.

Acta Pharmacol Sin. 2018 Dec;39(12):1894-1901. doi: 10.1038/s41401-018-0161-0. Epub 2018 Oct 8.

PMID:
30297804
7.

Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo.

Waskiewicz AJ, Johnson JC, Penn B, Mahalingam M, Kimball SR, Cooper JA.

Mol Cell Biol. 1999 Mar;19(3):1871-80.

8.

Inhibition of Mitogen-activated Protein Kinase (MAPK)-interacting Kinase (MNK) Preferentially Affects Translation of mRNAs Containing Both a 5'-Terminal Cap and Hairpin.

Korneeva NL, Song A, Gram H, Edens MA, Rhoads RE.

J Biol Chem. 2016 Feb 12;291(7):3455-67. doi: 10.1074/jbc.M115.694190. Epub 2015 Dec 14.

9.

eIF4E phosphorylation regulates ongoing pain, independently of inflammation, and hyperalgesic priming in the mouse CFA model.

Moy JK, Kuhn JL, Szabo-Pardi TA, Pradhan G, Price TJ.

Neurobiol Pain. 2018 Aug-Dec;4:45-50. doi: 10.1016/j.ynpai.2018.03.001. Epub 2018 Mar 15.

10.

Loss of eIF4E Phosphorylation Engenders Depression-like Behaviors via Selective mRNA Translation.

Amorim IS, Kedia S, Kouloulia S, Simbriger K, Gantois I, Jafarnejad SM, Li Y, Kampaite A, Pooters T, Romanò N, Gkogkas CG.

J Neurosci. 2018 Feb 21;38(8):2118-2133. doi: 10.1523/JNEUROSCI.2673-17.2018. Epub 2018 Jan 24.

11.

The androgen receptor is a negative regulator of eIF4E phosphorylation at S209: implications for the use of mTOR inhibitors in advanced prostate cancer.

D'Abronzo LS, Bose S, Crapuchettes ME, Beggs RE, Vinall RL, Tepper CG, Siddiqui S, Mudryj M, Melgoza FU, Durbin-Johnson BP, deVere White RW, Ghosh PM.

Oncogene. 2017 Nov 16;36(46):6359-6373. doi: 10.1038/onc.2017.233. Epub 2017 Jul 24.

12.
13.

eIF4E Phosphorylation Influences Bdnf mRNA Translation in Mouse Dorsal Root Ganglion Neurons.

Moy JK, Khoutorsky A, Asiedu MN, Dussor G, Price TJ.

Front Cell Neurosci. 2018 Feb 6;12:29. doi: 10.3389/fncel.2018.00029. eCollection 2018.

14.
15.

Simultaneous inhibition of mTOR-containing complex 1 (mTORC1) and MNK induces apoptosis of cutaneous T-cell lymphoma (CTCL) cells.

Marzec M, Liu X, Wysocka M, Rook AH, Odum N, Wasik MA.

PLoS One. 2011;6(9):e24849. doi: 10.1371/journal.pone.0024849. Epub 2011 Sep 16.

16.

BDNF stimulation of protein synthesis in cortical neurons requires the MAP kinase-interacting kinase MNK1.

Genheden M, Kenney JW, Johnston HE, Manousopoulou A, Garbis SD, Proud CG.

J Neurosci. 2015 Jan 21;35(3):972-84. doi: 10.1523/JNEUROSCI.2641-14.2015.

17.

Synergistic effects of inhibiting the MNK-eIF4E and PI3K/AKT/ mTOR pathways on cell migration in MDA-MB-231 cells.

Lineham E, Tizzard GJ, Coles SJ, Spencer J, Morley SJ.

Oncotarget. 2018 Jan 31;9(18):14148-14159. doi: 10.18632/oncotarget.24354. eCollection 2018 Mar 6.

18.

CGP57380 enhances efficacy of RAD001 in non-small cell lung cancer through abrogating mTOR inhibition-induced phosphorylation of eIF4E and activating mitochondrial apoptotic pathway.

Wen Q, Wang W, Luo J, Chu S, Chen L, Xu L, Zang H, Alnemah MM, Ma J, Fan S.

Oncotarget. 2016 May 10;7(19):27787-801. doi: 10.18632/oncotarget.8497.

19.

eIF4E-Dependent Translational Control: A Central Mechanism for Regulation of Pain Plasticity.

Uttam S, Wong C, Price TJ, Khoutorsky A.

Front Genet. 2018 Oct 24;9:470. doi: 10.3389/fgene.2018.00470. eCollection 2018. Review.

20.

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