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E-C coupling structural protein junctophilin-2 encodes a stress-adaptive transcription regulator.

Guo A, Wang Y, Chen B, Wang Y, Yuan J, Zhang L, Hall D, Wu J, Shi Y, Zhu Q, Chen C, Thiel WH, Zhan X, Weiss RM, Zhan F, Musselman CA, Pufall M, Zhu W, Au KF, Hong J, Anderson ME, Grueter CE, Song LS.

Science. 2018 Dec 21;362(6421). pii: eaan3303. doi: 10.1126/science.aan3303. Epub 2018 Nov 8.


Molecular Determinants of Calpain-dependent Cleavage of Junctophilin-2 Protein in Cardiomyocytes.

Guo A, Hall D, Zhang C, Peng T, Miller JD, Kutschke W, Grueter CE, Johnson FL, Lin RZ, Song LS.

J Biol Chem. 2015 Jul 17;290(29):17946-55. doi: 10.1074/jbc.M115.652396. Epub 2015 Jun 10.


Microtubule-mediated defects in junctophilin-2 trafficking contribute to myocyte transverse-tubule remodeling and Ca2+ handling dysfunction in heart failure.

Zhang C, Chen B, Guo A, Zhu Y, Miller JD, Gao S, Yuan C, Kutschke W, Zimmerman K, Weiss RM, Wehrens XH, Hong J, Johnson FL, Santana LF, Anderson ME, Song LS.

Circulation. 2014 Apr 29;129(17):1742-50. doi: 10.1161/CIRCULATIONAHA.113.008452. Epub 2014 Feb 11.


Overexpression of junctophilin-2 does not enhance baseline function but attenuates heart failure development after cardiac stress.

Guo A, Zhang X, Iyer VR, Chen B, Zhang C, Kutschke WJ, Weiss RM, Franzini-Armstrong C, Song LS.

Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12240-5. doi: 10.1073/pnas.1412729111. Epub 2014 Aug 4.


Mir-24 regulates junctophilin-2 expression in cardiomyocytes.

Xu M, Wu HD, Li RC, Zhang HB, Wang M, Tao J, Feng XH, Guo YB, Li SF, Lai ST, Zhou P, Li LL, Yang HQ, Luo GZ, Bai Y, Xi JJ, Gao W, Han QD, Zhang YY, Wang XJ, Meng X, Wang SQ.

Circ Res. 2012 Sep 14;111(7):837-41. doi: 10.1161/CIRCRESAHA.112.277418. Epub 2012 Aug 13.


Elevated ventricular wall stress disrupts cardiomyocyte t-tubule structure and calcium homeostasis.

Frisk M, Ruud M, Espe EK, Aronsen JM, Røe ÅT, Zhang L, Norseng PA, Sejersted OM, Christensen GA, Sjaastad I, Louch WE.

Cardiovasc Res. 2016 Oct;112(1):443-51. doi: 10.1093/cvr/cvw111. Epub 2016 May 25.


MAFbx/Atrogin-1 is required for atrophic remodeling of the unloaded heart.

Baskin KK, Rodriguez MR, Kansara S, Chen W, Carranza S, Frazier OH, Glass DJ, Taegtmeyer H.

J Mol Cell Cardiol. 2014 Jul;72:168-76. doi: 10.1016/j.yjmcc.2014.03.006. Epub 2014 Mar 18.


Activation of Na+/H+ exchanger 1 is sufficient to generate Ca2+ signals that induce cardiac hypertrophy and heart failure.

Nakamura TY, Iwata Y, Arai Y, Komamura K, Wakabayashi S.

Circ Res. 2008 Oct 10;103(8):891-9. doi: 10.1161/CIRCRESAHA.108.175141. Epub 2008 Sep 5.


Calpain-dependent cleavage of junctophilin-2 and T-tubule remodeling in a mouse model of reversible heart failure.

Wu CY, Chen B, Jiang YP, Jia Z, Martin DW, Liu S, Entcheva E, Song LS, Lin RZ.

J Am Heart Assoc. 2014 Jun 23;3(3):e000527. doi: 10.1161/JAHA.113.000527.


Early remodeling of perinuclear Ca2+ stores and nucleoplasmic Ca2+ signaling during the development of hypertrophy and heart failure.

Ljubojevic S, Radulovic S, Leitinger G, Sedej S, Sacherer M, Holzer M, Winkler C, Pritz E, Mittler T, Schmidt A, Sereinigg M, Wakula P, Zissimopoulos S, Bisping E, Post H, Marsche G, Bossuyt J, Bers DM, Kockskämper J, Pieske B.

Circulation. 2014 Jul 15;130(3):244-55. doi: 10.1161/CIRCULATIONAHA.114.008927. Epub 2014 Jun 13.


Receptor-independent protein kinase C alpha (PKCalpha) signaling by calpain-generated free catalytic domains induces HDAC5 nuclear export and regulates cardiac transcription.

Zhang Y, Matkovich SJ, Duan X, Diwan A, Kang MY, Dorn GW 2nd.

J Biol Chem. 2011 Jul 29;286(30):26943-51. doi: 10.1074/jbc.M111.234757. Epub 2011 Jun 3.


Critical roles of junctophilin-2 in T-tubule and excitation-contraction coupling maturation during postnatal development.

Chen B, Guo A, Zhang C, Chen R, Zhu Y, Hong J, Kutschke W, Zimmerman K, Weiss RM, Zingman L, Anderson ME, Wehrens XH, Song LS.

Cardiovasc Res. 2013 Oct 1;100(1):54-62. doi: 10.1093/cvr/cvt180. Epub 2013 Jul 16.


A nanoscale view of junctophilin-2 and ryanodine receptors.

[No authors listed]

J Cell Sci. 2016 Dec 1;129(23):e2303. No abstract available.


Role of calpain in eccentric contraction-induced proteolysis of Ca2+-regulatory proteins and force depression in rat fast-twitch skeletal muscle.

Kanzaki K, Watanabe D, Kuratani M, Yamada T, Matsunaga S, Wada M.

J Appl Physiol (1985). 2017 Feb 1;122(2):396-405. doi: 10.1152/japplphysiol.00270.2016. Epub 2016 Dec 15.


Calcium Signaling and Transcriptional Regulation in Cardiomyocytes.

Dewenter M, von der Lieth A, Katus HA, Backs J.

Circ Res. 2017 Sep 29;121(8):1000-1020. doi: 10.1161/CIRCRESAHA.117.310355. Review.


Calpain-dependent cleavage of N-cadherin is involved in the progression of post-myocardial infarction remodeling.

Kudo-Sakamoto Y, Akazawa H, Ito K, Takano J, Yano M, Yabumoto C, Naito AT, Oka T, Lee JK, Sakata Y, Suzuki J, Saido TC, Komuro I.

J Biol Chem. 2014 Jul 11;289(28):19408-19. doi: 10.1074/jbc.M114.567206. Epub 2014 Jun 2.


Inhibition of AP-1 signaling by JDP2 overexpression protects cardiomyocytes against hypertrophy and apoptosis induction.

Hill C, Würfel A, Heger J, Meyering B, Schlüter KD, Weber M, Ferdinandy P, Aronheim A, Schulz R, Euler G.

Cardiovasc Res. 2013 Jul 1;99(1):121-8. doi: 10.1093/cvr/cvt094. Epub 2013 Apr 23.


Subcellular compartmentalization of proximal Gαq-receptor signaling produces unique hypertrophic phenotypes in adult cardiac myocytes.

Dahl EF, Wu SC, Healy CL, Harsch BA, Shearer GC, O'Connell TD.

J Biol Chem. 2018 Jun 8;293(23):8734-8749. doi: 10.1074/jbc.RA118.002283. Epub 2018 Apr 2.


Cytosolic CARP promotes angiotensin II- or pressure overload-induced cardiomyocyte hypertrophy through calcineurin accumulation.

Chen C, Shen L, Cao S, Li X, Xuan W, Zhang J, Huang X, Bin J, Xu D, Li G, Kitakaze M, Liao Y.

PLoS One. 2014 Aug 4;9(8):e104040. doi: 10.1371/journal.pone.0104040. eCollection 2014.


Hydralazine and organic nitrates restore impaired excitation-contraction coupling by reducing calcium leak associated with nitroso-redox imbalance.

Dulce RA, Yiginer O, Gonzalez DR, Goss G, Feng N, Zheng M, Hare JM.

J Biol Chem. 2013 Mar 1;288(9):6522-33. doi: 10.1074/jbc.M112.412130. Epub 2013 Jan 14.

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