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Items: 1 to 20 of 100

1.

A Fluorescent Benzo[g]isoquinoline-Based HIF Prolyl Hydroxylase Inhibitor for Cellular Imaging.

Mayer M, Fey K, Heinze E, Wick CR, Abboud MI, Yeh TL, Tumber A, Orth N, Schley G, Buchholz B, Clark T, Schofield CJ, Willam C, Burzlaff N.

ChemMedChem. 2019 Jan 8;14(1):94-99. doi: 10.1002/cmdc.201800483. Epub 2018 Dec 21.

PMID:
30380199
2.

Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases.

Chan MC, Ilott NE, Schödel J, Sims D, Tumber A, Lippl K, Mole DR, Pugh CW, Ratcliffe PJ, Ponting CP, Schofield CJ.

J Biol Chem. 2016 Sep 23;291(39):20661-73. doi: 10.1074/jbc.M116.749291. Epub 2016 Aug 8.

3.

Prolyl hydroxylase inhibitor treatment confers whole-animal hypoxia tolerance.

Kasiganesan H, Sridharan V, Wright G.

Acta Physiol (Oxf). 2007 Jun;190(2):163-9. Epub 2007 Mar 30.

PMID:
17394573
4.

Pre- and post-conditional inhibition of prolyl-4-hydroxylase domain enzymes protects the heart from an ischemic insult.

Vogler M, Zieseniss A, Hesse AR, Levent E, Tiburcy M, Heinze E, Burzlaff N, Schley G, Eckardt KU, Willam C, Katschinski DM.

Pflugers Arch. 2015 Oct;467(10):2141-9. doi: 10.1007/s00424-014-1667-z. Epub 2015 Jan 13.

PMID:
25578858
5.

Complement C1q is hydroxylated by collagen prolyl 4 hydroxylase and is sensitive to off-target inhibition by prolyl hydroxylase domain inhibitors that stabilize hypoxia-inducible factor.

Kiriakidis S, Hoer SS, Burrows N, Biddlecome G, Khan MN, Thinnes CC, Schofield CJ, Rogers N, Botto M, Paleolog E, Maxwell PH.

Kidney Int. 2017 Oct;92(4):900-908. doi: 10.1016/j.kint.2017.03.008. Epub 2017 May 12.

6.

Molecular characterization and mRNA expression of two key enzymes of hypoxia-sensing pathways in eastern oysters Crassostrea virginica (Gmelin): hypoxia-inducible factor α (HIF-α) and HIF-prolyl hydroxylase (PHD).

Piontkivska H, Chung JS, Ivanina AV, Sokolov EP, Techa S, Sokolova IM.

Comp Biochem Physiol Part D Genomics Proteomics. 2011 Jun;6(2):103-14. doi: 10.1016/j.cbd.2010.10.003. Epub 2010 Oct 30.

7.

HIF-prolyl hydroxylases and cardiovascular diseases.

Sen Banerjee S, Thirunavukkarasu M, Tipu Rishi M, Sanchez JA, Maulik N, Maulik G.

Toxicol Mech Methods. 2012 Jun;22(5):347-58. doi: 10.3109/15376516.2012.673088. Review.

PMID:
22424133
8.

Genetic Knockdown and Pharmacologic Inhibition of Hypoxia-Inducible Factor (HIF) Hydroxylases.

Pickel C, Taylor CT, Scholz CC.

Methods Mol Biol. 2018;1742:1-14. doi: 10.1007/978-1-4939-7665-2_1.

PMID:
29330785
9.

Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2).

McDonough MA, Li V, Flashman E, Chowdhury R, Mohr C, Liénard BM, Zondlo J, Oldham NJ, Clifton IJ, Lewis J, McNeill LA, Kurzeja RJ, Hewitson KS, Yang E, Jordan S, Syed RS, Schofield CJ.

Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9814-9. Epub 2006 Jun 16.

10.

Oxygen sensing by the prolyl-4-hydroxylase PHD2 within the nuclear compartment and the influence of compartmentalisation on HIF-1 signalling.

Pientka FK, Hu J, Schindler SG, Brix B, Thiel A, Jöhren O, Fandrey J, Berchner-Pfannschmidt U, Depping R.

J Cell Sci. 2012 Nov 1;125(Pt 21):5168-76. doi: 10.1242/jcs.109041. Epub 2012 Sep 3.

11.

Molecular evolution of the metazoan PHD-HIF oxygen-sensing system.

Rytkönen KT, Williams TA, Renshaw GM, Primmer CR, Nikinmaa M.

Mol Biol Evol. 2011 Jun;28(6):1913-26. doi: 10.1093/molbev/msr012. Epub 2011 Jan 12.

PMID:
21228399
12.

The Role of Hypoxia-Inducible Factor/Prolyl Hydroxylation Pathway in Deoxycorticosterone Acetate/Salt Hypertension in the Rat.

Dallatu MK, Nwokocha E, Agu N, Myung C, Newaz MA, Garcia G, Truong LD, Oyekan AO.

J Hypertens (Los Angel). 2014 Dec;3(6). pii: 184.

13.

Copper-dependent activation of hypoxia-inducible factor (HIF)-1: implications for ceruloplasmin regulation.

Martin F, Linden T, Katschinski DM, Oehme F, Flamme I, Mukhopadhyay CK, Eckhardt K, Tröger J, Barth S, Camenisch G, Wenger RH.

Blood. 2005 Jun 15;105(12):4613-9. Epub 2005 Mar 1.

14.

Multiple factors affecting cellular redox status and energy metabolism modulate hypoxia-inducible factor prolyl hydroxylase activity in vivo and in vitro.

Pan Y, Mansfield KD, Bertozzi CC, Rudenko V, Chan DA, Giaccia AJ, Simon MC.

Mol Cell Biol. 2007 Feb;27(3):912-25. Epub 2006 Nov 13.

15.

Disruption of hypoxia-inducible transcription factor-prolyl hydroxylase domain-1 (PHD-1-/-) attenuates ex vivo myocardial ischemia/reperfusion injury through hypoxia-inducible factor-1α transcription factor and its target genes in mice.

Adluri RS, Thirunavukkarasu M, Dunna NR, Zhan L, Oriowo B, Takeda K, Sanchez JA, Otani H, Maulik G, Fong GH, Maulik N.

Antioxid Redox Signal. 2011 Oct 1;15(7):1789-97. doi: 10.1089/ars.2010.3769. Epub 2011 Apr 8.

16.

Prolyl hydroxylase domain enzymes: important regulators of cancer metabolism.

Yang M, Su H, Soga T, Kranc KR, Pollard PJ.

Hypoxia (Auckl). 2014 Aug 30;2:127-142. eCollection 2014. Review.

17.

Hypoxia-inducible factor prolyl-hydroxylase: purification and assays of PHD2.

Hewitson KS, Schofield CJ, Ratcliffe PJ.

Methods Enzymol. 2007;435:25-42.

PMID:
17998047
18.

Prolyl hydroxylase domain enzyme 2 is the major player in regulating hypoxic responses in rheumatoid arthritis.

Muz B, Larsen H, Madden L, Kiriakidis S, Paleolog EM.

Arthritis Rheum. 2012 Sep;64(9):2856-67. doi: 10.1002/art.34479.

19.
20.

Role and regulation of prolyl hydroxylase domain proteins.

Fong GH, Takeda K.

Cell Death Differ. 2008 Apr;15(4):635-41. doi: 10.1038/cdd.2008.10. Epub 2008 Feb 15. Review.

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