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Items: 1 to 20 of 98

1.

Rhodium(III)-Based Inhibitor of the JMJD3-H3K27me3 Interaction and Modulator of the Inflammatory Response.

Kang TS, Ko CN, Zhang JT, Wu C, Wong CY, Ma DL, Leung CH.

Inorg Chem. 2018 Nov 19;57(22):14023-14026. doi: 10.1021/acs.inorgchem.8b02256. Epub 2018 Oct 30.

PMID:
30375229
2.

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response.

Kruidenier L, Chung CW, Cheng Z, Liddle J, Che K, Joberty G, Bantscheff M, Bountra C, Bridges A, Diallo H, Eberhard D, Hutchinson S, Jones E, Katso R, Leveridge M, Mander PK, Mosley J, Ramirez-Molina C, Rowland P, Schofield CJ, Sheppard RJ, Smith JE, Swales C, Tanner R, Thomas P, Tumber A, Drewes G, Oppermann U, Patel DJ, Lee K, Wilson DM.

Nature. 2012 Aug 16;488(7411):404-8. doi: 10.1038/nature11262.

3.

The localization of histone H3K27me3 demethylase Jmjd3 is dynamically regulated.

Kamikawa YF, Donohoe ME.

Epigenetics. 2014 Jun;9(6):834-41. doi: 10.4161/epi.28524. Epub 2014 Mar 19.

4.

Jmjd3-mediated epigenetic regulation of inflammatory cytokine gene expression in serum amyloid A-stimulated macrophages.

Yan Q, Sun L, Zhu Z, Wang L, Li S, Ye RD.

Cell Signal. 2014 Sep;26(9):1783-91. doi: 10.1016/j.cellsig.2014.03.025. Epub 2014 Apr 1.

5.

Inhibition of H3K27me3-specific histone demethylases JMJD3 and UTX blocks reactivation of herpes simplex virus 1 in trigeminal ganglion neurons.

Messer HG, Jacobs D, Dhummakupt A, Bloom DC.

J Virol. 2015 Mar;89(6):3417-20. doi: 10.1128/JVI.03052-14. Epub 2014 Dec 31.

6.

Histone demethylase JMJD3 regulates CD11a expression through changes in histone H3K27 tri-methylation levels in CD4+ T cells of patients with systemic lupus erythematosus.

Yin H, Wu H, Zhao M, Zhang Q, Long H, Fu S, Lu Q.

Oncotarget. 2017 Jul 25;8(30):48938-48947. doi: 10.18632/oncotarget.16894.

7.

Endogenous hydrogen sulfide regulates histone demethylase JMJD3-mediated inflammatory response in LPS-stimulated macrophages and in a mouse model of LPS-induced septic shock.

Liu S, Wang X, Pan L, Wu W, Yang D, Qin M, Jia W, Xiao C, Long F, Ge J, Liu X, Zhu Y.

Biochem Pharmacol. 2018 Mar;149:153-162. doi: 10.1016/j.bcp.2017.10.010. Epub 2017 Oct 23.

PMID:
29074105
8.

Histone demethylase Jmjd3 regulates osteoblast differentiation via transcription factors Runx2 and osterix.

Yang D, Okamura H, Nakashima Y, Haneji T.

J Biol Chem. 2013 Nov 22;288(47):33530-41. doi: 10.1074/jbc.M113.497040. Epub 2013 Oct 8.

9.

Epigenetic regulation of osteoclast differentiation: possible involvement of Jmjd3 in the histone demethylation of Nfatc1.

Yasui T, Hirose J, Tsutsumi S, Nakamura K, Aburatani H, Tanaka S.

J Bone Miner Res. 2011 Nov;26(11):2665-71. doi: 10.1002/jbmr.464.

10.

[Distributions of H3K27me3 and its modification enzymes in different tissues of mice].

Wang Y, Wang X, Zhang R, Zhang Z, Wang Y, Yang B, Wang G, Zhang X, Ma F, Xu H, Wu X, Zhang F, Li Q.

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2017 Nov;33(11):1491-1497. Chinese.

PMID:
29268852
11.

The histone H3 Lys 27 demethylase JMJD3 regulates gene expression by impacting transcriptional elongation.

Chen S, Ma J, Wu F, Xiong LJ, Ma H, Xu W, Lv R, Li X, Villen J, Gygi SP, Liu XS, Shi Y.

Genes Dev. 2012 Jun 15;26(12):1364-75. doi: 10.1101/gad.186056.111.

12.

Inhibited expression of hematopoietic progenitor kinase 1 associated with loss of jumonji domain containing 3 promoter binding contributes to autoimmunity in systemic lupus erythematosus.

Zhang Q, Long H, Liao J, Zhao M, Liang G, Wu X, Zhang P, Ding S, Luo S, Lu Q.

J Autoimmun. 2011 Nov;37(3):180-9. doi: 10.1016/j.jaut.2011.09.006. Epub 2011 Oct 19.

PMID:
22014533
13.

Jumonji domain-containing protein 3 regulates histone 3 lysine 27 methylation during bovine preimplantation development.

Canovas S, Cibelli JB, Ross PJ.

Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2400-5. doi: 10.1073/pnas.1119112109. Epub 2012 Jan 30.

14.

The signal transducers Stat1 and Stat3 and their novel target Jmjd3 drive the expression of inflammatory genes in microglia.

Przanowski P, Dabrowski M, Ellert-Miklaszewska A, Kloss M, Mieczkowski J, Kaza B, Ronowicz A, Hu F, Piotrowski A, Kettenmann H, Komorowski J, Kaminska B.

J Mol Med (Berl). 2014 Mar;92(3):239-54. doi: 10.1007/s00109-013-1090-5. Epub 2013 Oct 6.

15.

Design and discovery of new pyrimidine coupled nitrogen aromatic rings as chelating groups of JMJD3 inhibitors.

Hu J, Wang X, Chen L, Huang M, Tang W, Zuo J, Liu YC, Shi Z, Liu R, Shen J, Xiong B.

Bioorg Med Chem Lett. 2016 Feb 1;26(3):721-725. doi: 10.1016/j.bmcl.2016.01.006. Epub 2016 Jan 7.

PMID:
26776360
16.

Histone demethylase Jmjd3 regulates osteoblast apoptosis through targeting anti-apoptotic protein Bcl-2 and pro-apoptotic protein Bim.

Yang D, Okamura H, Teramachi J, Haneji T.

Biochim Biophys Acta. 2016 Apr;1863(4):650-9. doi: 10.1016/j.bbamcr.2016.01.006. Epub 2016 Jan 12.

17.

Overexpression of JMJD3 may contribute to demethylation of H3K27me3 in CD4+ T cells from patients with systemic sclerosis.

Wang Q, Xiao Y, Shi Y, Luo Y, Li Y, Zhao M, Lu Q, Xiao R.

Clin Immunol. 2015 Dec;161(2):396-9. doi: 10.1016/j.clim.2015.03.006. Epub 2015 Mar 17. No abstract available.

PMID:
25791244
18.

Histone demethylase Jmjd3 is required for the development of subsets of retinal bipolar cells.

Iida A, Iwagawa T, Kuribayashi H, Satoh S, Mochizuki Y, Baba Y, Nakauchi H, Furukawa T, Koseki H, Murakami A, Watanabe S.

Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3751-6. doi: 10.1073/pnas.1311480111. Epub 2014 Feb 26.

19.

Hypoxic reprograming of H3K27me3 and H3K4me3 at the INK4A locus.

Chang S, Park B, Choi K, Moon Y, Lee HY, Park H.

FEBS Lett. 2016 Oct;590(19):3407-3415. doi: 10.1002/1873-3468.12375. Epub 2016 Sep 7.

20.

An Iridium(III) Complex Inhibits JMJD2 Activities and Acts as a Potential Epigenetic Modulator.

Liu LJ, Lu L, Zhong HJ, He B, Kwong DW, Ma DL, Leung CH.

J Med Chem. 2015 Aug 27;58(16):6697-703. doi: 10.1021/acs.jmedchem.5b00375. Epub 2015 Aug 11.

PMID:
26225543

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