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Items: 1 to 20 of 101

1.

Discovery and synthesis of tetrahydropyrimidinedione-4-carboxamides as endothelial lipase inhibitors.

Hu CH, Wang TC, Qiao JX, Haque L, Chen AYA, Taylor DS, Ying X, Onorato JM, Galella M, Shen H, Huang CS, Toussaint N, Li YX, Abell L, Adam LP, Gordon D, Wexler RR, Finlay HJ.

Bioorg Med Chem Lett. 2018 Dec 15;28(23-24):3721-3725. doi: 10.1016/j.bmcl.2018.10.022. Epub 2018 Oct 15.

PMID:
30348490
2.

PK/PD Disconnect Observed with a Reversible Endothelial Lipase Inhibitor.

Hangeland JJ, Abell LM, Adam LP, Jiang J, Friends TJ, Haque LE, Neels J, Onorato JM, Chen AYA, Taylor DS, Yin X, Harrity TW, Basso MD, Yang R, Sleph PG, Gordon DA, Huang CS, Wexler RR, Finlay HJ, Lawrence RM.

ACS Med Chem Lett. 2018 Jun 15;9(7):673-678. doi: 10.1021/acsmedchemlett.8b00138. eCollection 2018 Jul 12.

PMID:
30034599
3.
4.

Sulfonylated Benzothiazoles as Inhibitors of Endothelial Lipase.

Johnson JA, Tora G, Pi Z, Phillips M, Yin X, Yang R, Zhao L, Chen AY, Taylor DS, Basso M, Rose A, Behnia K, Onorato J, Chen XQ, Abell LM, Lu H, Locke G, Caporuscio C, Galella M, Adam LP, Gordon D, Wexler RR, Finlay HJ.

ACS Med Chem Lett. 2018 Nov 21;9(12):1263-1268. doi: 10.1021/acsmedchemlett.8b00424. eCollection 2018 Dec 13.

PMID:
30613337
5.

Discovery of XEN445: a potent and selective endothelial lipase inhibitor raises plasma HDL-cholesterol concentration in mice.

Sun S, Dean R, Jia Q, Zenova A, Zhong J, Grayson C, Xie C, Lindgren A, Samra P, Sojo L, van Heek M, Lin L, Percival D, Fu JM, Winther MD, Zhang Z.

Bioorg Med Chem. 2013 Dec 15;21(24):7724-34. doi: 10.1016/j.bmc.2013.10.023. Epub 2013 Oct 28.

PMID:
24211162
6.

Long-chain polyunsaturated fatty acids, endothelial lipase and atherosclerosis.

Das UN.

Prostaglandins Leukot Essent Fatty Acids. 2005 Mar;72(3):173-9. Review.

PMID:
15664301
7.

Interleukin 6 stimulates endothelial binding and transport of high-density lipoprotein through induction of endothelial lipase.

Robert J, Lehner M, Frank S, Perisa D, von Eckardstein A, Rohrer L.

Arterioscler Thromb Vasc Biol. 2013 Dec;33(12):2699-706. doi: 10.1161/ATVBAHA.113.301363. Epub 2013 Oct 10.

PMID:
24115033
8.

Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors.

Goodman KB, Bury MJ, Cheung M, Cichy-Knight MA, Dowdell SE, Dunn AK, Lee D, Lieby JA, Moore ML, Scherzer DA, Sha D, Suarez DP, Murphy DJ, Harpel MR, Manas ES, McNulty DE, Annan RS, Matico RE, Schwartz BK, Trill JJ, Sweitzer TD, Wang DY, Keller PM, Krawiec JA, Jaye MC.

Bioorg Med Chem Lett. 2009 Jan 1;19(1):27-30. doi: 10.1016/j.bmcl.2008.11.033. Epub 2008 Nov 14.

PMID:
19058966
9.

Impact of combined deficiency of hepatic lipase and endothelial lipase on the metabolism of both high-density lipoproteins and apolipoprotein B-containing lipoproteins.

Brown RJ, Lagor WR, Sankaranaravanan S, Yasuda T, Quertermous T, Rothblat GH, Rader DJ.

Circ Res. 2010 Aug 6;107(3):357-64. doi: 10.1161/CIRCRESAHA.110.219188. Epub 2010 Jun 17.

10.

Pitavastatin decreases the expression of endothelial lipase both in vitro and in vivo.

Kojima Y, Ishida T, Sun L, Yasuda T, Toh R, Rikitake Y, Fukuda A, Kume N, Koshiyama H, Taniguchi A, Hirata K.

Cardiovasc Res. 2010 Jul 15;87(2):385-93. doi: 10.1093/cvr/cvp419. Epub 2010 Jan 2.

PMID:
20045866
11.

High-density lipoprotein hydrolysis by endothelial lipase activates PPARalpha: a candidate mechanism for high-density lipoprotein-mediated repression of leukocyte adhesion.

Ahmed W, Orasanu G, Nehra V, Asatryan L, Rader DJ, Ziouzenkova O, Plutzky J.

Circ Res. 2006 Mar 3;98(4):490-8. Epub 2006 Jan 26.

12.

Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism.

Ma K, Cilingiroglu M, Otvos JD, Ballantyne CM, Marian AJ, Chan L.

Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2748-53. Epub 2003 Feb 24.

13.

Structural basis of endothelial lipase tropism for HDL.

Broedl UC, Jin W, Fuki IV, Glick JM, Rader DJ.

FASEB J. 2004 Dec;18(15):1891-3. Epub 2004 Sep 28.

PMID:
15456739
14.

High-density lipoprotein subfractions and influence of endothelial lipase in a healthy Turkish population: a study in a land of low high-density lipoprotein cholesterol.

Kilic H, Atalar E, Lay I, Yazihan N, Buyukcam F, Saygisunar U, Aksoy M, Gunduz H, Akdemir R.

Scand J Clin Lab Invest. 2014 Jun;74(4):278-84. doi: 10.3109/00365513.2013.879992. Epub 2014 Jan 30.

PMID:
24479875
15.

A high-throughput screen for endothelial lipase using HDL as substrate.

Keller PM, Rust T, Murphy DJ, Matico R, Trill JJ, Krawiec JA, Jurewicz A, Jaye M, Harpel M, Thrall S, Schwartz B.

J Biomol Screen. 2008 Jul;13(6):468-75. doi: 10.1177/1087057108319738. Epub 2008 Jun 19.

PMID:
18566479
16.

Identification of genetic variants in endothelial lipase in persons with elevated high-density lipoprotein cholesterol.

deLemos AS, Wolfe ML, Long CJ, Sivapackianathan R, Rader DJ.

Circulation. 2002 Sep 10;106(11):1321-6.

PMID:
12221047
17.

Design and synthesis of boronic acid inhibitors of endothelial lipase.

O'Connell DP, LeBlanc DF, Cromley D, Billheimer J, Rader DJ, Bachovchin WW.

Bioorg Med Chem Lett. 2012 Feb 1;22(3):1397-401. doi: 10.1016/j.bmcl.2011.12.043. Epub 2011 Dec 13.

PMID:
22225633
18.

Role of endothelial lipase in plasma HDL levels in a murine model of hypertriglyceridemia.

Tanaka H, Ishida T, Johnston TP, Yasuda T, Ueyama T, Kojima Y, Kundu RK, Quertermous T, Ishikawa Y, Hirata K.

J Atheroscler Thromb. 2009 Aug;16(4):327-38. Epub 2009 Aug 11.

19.

Endothelial lipase and cholesterol metabolism.

Cilingiroglu M, Ballantyne C.

Curr Atheroscler Rep. 2004 Mar;6(2):126-30. Review.

PMID:
15023297
20.

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