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Items: 1 to 20 of 108

1.

Switching obese mothers to a healthy diet improves fetal hypoxemia, hepatic metabolites, and lipotoxicity in non-human primates.

Wesolowski SR, Mulligan CM, Janssen RC, Baker PR 2nd, Bergman BC, D'Alessandro A, Nemkov T, Maclean KN, Jiang H, Dean TA, Takahashi DL, Kievit P, McCurdy CE, Aagaard KM, Friedman JE.

Mol Metab. 2018 Dec;18:25-41. doi: 10.1016/j.molmet.2018.09.008. Epub 2018 Sep 28.

2.

Maternal obesity reduces oxidative capacity in fetal skeletal muscle of Japanese macaques.

McCurdy CE, Schenk S, Hetrick B, Houck J, Drew BG, Kaye S, Lashbrook M, Bergman BC, Takahashi DL, Dean TA, Nemkov T, Gertsman I, Hansen KC, Philp A, Hevener AL, Chicco AJ, Aagaard KM, Grove KL, Friedman JE.

JCI Insight. 2016 Oct 6;1(16):e86612. doi: 10.1172/jci.insight.86612.

3.

Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates.

McCurdy CE, Bishop JM, Williams SM, Grayson BE, Smith MS, Friedman JE, Grove KL.

J Clin Invest. 2009 Feb;119(2):323-35. doi: 10.1172/JCI32661. Epub 2009 Jan 19.

4.

Maternal obesity upregulates fatty acid and glucose transporters and increases expression of enzymes mediating fatty acid biosynthesis in fetal adipose tissue depots.

Long NM, Rule DC, Zhu MJ, Nathanielsz PW, Ford SP.

J Anim Sci. 2012 Jul;90(7):2201-10. doi: 10.2527/jas.2011-4343. Epub 2012 Jan 20.

PMID:
22266999
5.

Expression of epigenetic machinery genes is sensitive to maternal obesity and weight loss in relation to fetal growth in mice.

Panchenko PE, Voisin S, Jouin M, Jouneau L, Prézelin A, Lecoutre S, Breton C, Jammes H, Junien C, Gabory A.

Clin Epigenetics. 2016 Feb 27;8:22. doi: 10.1186/s13148-016-0188-3. eCollection 2016.

6.

iPLA2β deficiency attenuates obesity and hepatic steatosis in ob/ob mice through hepatic fatty-acyl phospholipid remodeling.

Deng X, Wang J, Jiao L, Utaipan T, Tuma-Kellner S, Schmitz G, Liebisch G, Stremmel W, Chamulitrat W.

Biochim Biophys Acta. 2016 May;1861(5):449-61. doi: 10.1016/j.bbalip.2016.02.004. Epub 2016 Feb 9.

PMID:
26873633
7.

AMP-activated protein kinase signalling pathways are down regulated and skeletal muscle development impaired in fetuses of obese, over-nourished sheep.

Zhu MJ, Han B, Tong J, Ma C, Kimzey JM, Underwood KR, Xiao Y, Hess BW, Ford SP, Nathanielsz PW, Du M.

J Physiol. 2008 May 15;586(10):2651-64. doi: 10.1113/jphysiol.2007.149633. Epub 2008 Mar 27.

8.

Early PQQ supplementation has persistent long-term protective effects on developmental programming of hepatic lipotoxicity and inflammation in obese mice.

Jonscher KR, Stewart MS, Alfonso-Garcia A, DeFelice BC, Wang XX, Luo Y, Levi M, Heerwagen MJ, Janssen RC, de la Houssaye BA, Wiitala E, Florey G, Jonscher RL, Potma EO, Fiehn O, Friedman JE.

FASEB J. 2017 Apr;31(4):1434-1448. doi: 10.1096/fj.201600906R. Epub 2016 Dec 22.

9.

Maternal obesity-impaired insulin signaling in sheep and induced lipid accumulation and fibrosis in skeletal muscle of offspring.

Yan X, Huang Y, Zhao JX, Long NM, Uthlaut AB, Zhu MJ, Ford SP, Nathanielsz PW, Du M.

Biol Reprod. 2011 Jul;85(1):172-8. doi: 10.1095/biolreprod.110.089649. Epub 2011 Feb 23.

10.

Maternal high-fat diet reversal improves placental hemodynamics in a nonhuman primate model of diet-induced obesity.

Salati JA, Roberts VHJ, Schabel MC, Lo JO, Kroenke CD, Lewandowski KS, Lindner JR, Grove KL, Frias AE.

Int J Obes (Lond). 2019 Apr;43(4):906-916. doi: 10.1038/s41366-018-0145-7. Epub 2018 Jul 13.

11.

Sustained hypoxemia in late gestation potentiates hepatic gluconeogenic gene expression but does not activate glucose production in the ovine fetus.

Jones AK, Rozance PJ, Brown LD, Goldstrohm DA, Hay WW Jr, Limesand SW, Wesolowski SR.

Am J Physiol Endocrinol Metab. 2019 Apr 9. doi: 10.1152/ajpendo.00069.2019. [Epub ahead of print]

PMID:
30964701
12.

Early life exposure to maternal insulin resistance has persistent effects on hepatic NAFLD in juvenile nonhuman primates.

Thorn SR, Baquero KC, Newsom SA, El Kasmi KC, Bergman BC, Shulman GI, Grove KL, Friedman JE.

Diabetes. 2014 Aug;63(8):2702-13. doi: 10.2337/db14-0276. Epub 2014 Apr 4.

13.

Methionine restriction prevents the progression of hepatic steatosis in leptin-deficient obese mice.

Malloy VL, Perrone CE, Mattocks DA, Ables GP, Caliendo NS, Orentreich DS, Orentreich N.

Metabolism. 2013 Nov;62(11):1651-61. doi: 10.1016/j.metabol.2013.06.012. Epub 2013 Aug 5.

PMID:
23928105
14.

A physiological increase in insulin suppresses gluconeogenic gene activation in fetal sheep with sustained hypoglycemia.

Thorn SR, Sekar SM, Lavezzi JR, O'Meara MC, Brown LD, Hay WW Jr, Rozance PJ.

Am J Physiol Regul Integr Comp Physiol. 2012 Oct 15;303(8):R861-9. doi: 10.1152/ajpregu.00331.2012. Epub 2012 Aug 29.

15.

Transgenic increase in N-3/n-6 Fatty Acid ratio reduces maternal obesity-associated inflammation and limits adverse developmental programming in mice.

Heerwagen MJ, Stewart MS, de la Houssaye BA, Janssen RC, Friedman JE.

PLoS One. 2013 Jun 25;8(6):e67791. doi: 10.1371/journal.pone.0067791. Print 2013.

16.

Developmental origins of disease and determinants of chromatin structure: maternal diet modifies the primate fetal epigenome.

Aagaard-Tillery KM, Grove K, Bishop J, Ke X, Fu Q, McKnight R, Lane RH.

J Mol Endocrinol. 2008 Aug;41(2):91-102. doi: 10.1677/JME-08-0025. Epub 2008 May 30.

17.

Diet reduction to requirements in obese/overfed ewes from early gestation prevents glucose/insulin dysregulation and returns fetal adiposity and organ development to control levels.

Tuersunjiang N, Odhiambo JF, Long NM, Shasa DR, Nathanielsz PW, Ford SP.

Am J Physiol Endocrinol Metab. 2013 Oct 1;305(7):E868-78. doi: 10.1152/ajpendo.00117.2013. Epub 2013 Aug 6.

18.

Oral citrulline supplementation protects female mice from the development of non-alcoholic fatty liver disease (NAFLD).

Sellmann C, Jin CJ, Engstler AJ, De Bandt JP, Bergheim I.

Eur J Nutr. 2017 Dec;56(8):2519-2527. doi: 10.1007/s00394-016-1287-9. Epub 2016 Aug 5.

PMID:
27496089
19.

Primate fetal hepatic responses to maternal obesity: epigenetic signalling pathways and lipid accumulation.

Puppala S, Li C, Glenn JP, Saxena R, Gawrieh S, Quinn A, Palarczyk J, Dick EJ Jr, Nathanielsz PW, Cox LA.

J Physiol. 2018 Dec;596(23):5823-5837. doi: 10.1113/JP275422. Epub 2018 Apr 6.

PMID:
29516496
20.

Low and high dietary protein:carbohydrate ratios during pregnancy affect materno-fetal glucose metabolism in pigs.

Metges CC, Görs S, Lang IS, Hammon HM, Brüssow KP, Weitzel JM, Nürnberg G, Rehfeldt C, Otten W.

J Nutr. 2014 Feb;144(2):155-63. doi: 10.3945/jn.113.182691. Epub 2013 Dec 18.

PMID:
24353346

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