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Items: 1 to 20 of 98

1.

Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis.

Soberanes S, Misharin AV, Jairaman A, Morales-Nebreda L, McQuattie-Pimentel AC, Cho T, Hamanaka RB, Meliton AY, Reyfman PA, Walter JM, Chen CI, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Antalek M, Abdala-Valencia H, Chiarella SE, Sun KA, Woods PS, Ghio AJ, Jain M, Perlman H, Ridge KM, Morimoto RI, Sznajder JI, Balch WE, Bhorade SM, Bharat A, Prakriya M, Chandel NS, Mutlu GM, Budinger GRS.

Cell Metab. 2019 Feb 5;29(2):335-347.e5. doi: 10.1016/j.cmet.2018.09.019. Epub 2018 Oct 11. Erratum in: Cell Metab. 2019 Feb 5;29(2):503.

PMID:
30318339
2.

Mitochondrial complex III-generated oxidants activate ASK1 and JNK to induce alveolar epithelial cell death following exposure to particulate matter air pollution.

Soberanes S, Urich D, Baker CM, Burgess Z, Chiarella SE, Bell EL, Ghio AJ, De Vizcaya-Ruiz A, Liu J, Ridge KM, Kamp DW, Chandel NS, Schumacker PT, Mutlu GM, Budinger GR.

J Biol Chem. 2009 Jan 23;284(4):2176-86. doi: 10.1074/jbc.M808844200. Epub 2008 Nov 25.

3.

β₂-Adrenergic agonists augment air pollution-induced IL-6 release and thrombosis.

Chiarella SE, Soberanes S, Urich D, Morales-Nebreda L, Nigdelioglu R, Green D, Young JB, Gonzalez A, Rosario C, Misharin AV, Ghio AJ, Wunderink RG, Donnelly HK, Radigan KA, Perlman H, Chandel NS, Budinger GR, Mutlu GM.

J Clin Invest. 2014 Jul;124(7):2935-46. doi: 10.1172/JCI75157. Epub 2014 May 27.

4.

Metformin Uniquely Prevents Thrombosis by Inhibiting Platelet Activation and mtDNA Release.

Xin G, Wei Z, Ji C, Zheng H, Gu J, Ma L, Huang W, Morris-Natschke SL, Yeh JL, Zhang R, Qin C, Wen L, Xing Z, Cao Y, Xia Q, Lu Y, Li K, Niu H, Lee KH, Huang W.

Sci Rep. 2016 Nov 2;6:36222. doi: 10.1038/srep36222.

5.

Acute exposure to air pollution particulate matter aggravates experimental myocardial infarction in mice by potentiating cytokine secretion from lung macrophages.

Marchini T, Wolf D, Michel NA, Mauler M, Dufner B, Hoppe N, Beckert J, Jäckel M, Magnani N, Duerschmied D, Tasat D, Alvarez S, Reinöhl J, von Zur Muhlen C, Idzko M, Bode C, Hilgendorf I, Evelson P, Zirlik A.

Basic Res Cardiol. 2016 Jul;111(4):44. doi: 10.1007/s00395-016-0562-5. Epub 2016 May 30.

6.

Direct effects of airborne PM2.5 exposure on macrophage polarizations.

Zhao Q, Chen H, Yang T, Rui W, Liu F, Zhang F, Zhao Y, Ding W.

Biochim Biophys Acta. 2016 Dec;1860(12):2835-43. doi: 10.1016/j.bbagen.2016.03.033. Epub 2016 Apr 16.

PMID:
27041089
7.

Diesel exhaust inhalation exposure induces pulmonary arterial hypertension in mice.

Liu J, Ye X, Ji D, Zhou X, Qiu C, Liu W, Yu L.

Environ Pollut. 2018 Jun;237:747-755. doi: 10.1016/j.envpol.2017.10.121. Epub 2017 Nov 11.

PMID:
29137886
9.

Mitochondrial genetic background modifies the relationship between traffic-related air pollution exposure and systemic biomarkers of inflammation.

Wittkopp S, Staimer N, Tjoa T, Gillen D, Daher N, Shafer M, Schauer JJ, Sioutas C, Delfino RJ.

PLoS One. 2013 May 23;8(5):e64444. doi: 10.1371/journal.pone.0064444. Print 2013.

10.

Metformin Mediates Protection against Legionella Pneumonia through Activation of AMPK and Mitochondrial Reactive Oxygen Species.

Kajiwara C, Kusaka Y, Kimura S, Yamaguchi T, Nanjo Y, Ishii Y, Udono H, Standiford TJ, Tateda K.

J Immunol. 2018 Jan 15;200(2):623-631. doi: 10.4049/jimmunol.1700474. Epub 2017 Dec 15.

11.

Ambient particulate matter accelerates coagulation via an IL-6-dependent pathway.

Mutlu GM, Green D, Bellmeyer A, Baker CM, Burgess Z, Rajamannan N, Christman JW, Foiles N, Kamp DW, Ghio AJ, Chandel NS, Dean DA, Sznajder JI, Budinger GR.

J Clin Invest. 2007 Oct;117(10):2952-61.

12.

Insulin sensitizers prevent fine particulate matter-induced vascular insulin resistance and changes in endothelial progenitor cell homeostasis.

Haberzettl P, McCracken JP, Bhatnagar A, Conklin DJ.

Am J Physiol Heart Circ Physiol. 2016 Jun 1;310(11):H1423-38. doi: 10.1152/ajpheart.00369.2015. Epub 2016 Mar 25.

13.

Ambient particulate air pollution induces oxidative stress and alterations of mitochondria and gene expression in brown and white adipose tissues.

Xu Z, Xu X, Zhong M, Hotchkiss IP, Lewandowski RP, Wagner JG, Bramble LA, Yang Y, Wang A, Harkema JR, Lippmann M, Rajagopalan S, Chen LC, Sun Q.

Part Fibre Toxicol. 2011 Jul 11;8:20. doi: 10.1186/1743-8977-8-20.

14.

The effects of ambient particulate matter on human alveolar macrophage oxidative and inflammatory responses.

Sawyer K, Mundandhara S, Ghio AJ, Madden MC.

J Toxicol Environ Health A. 2010;73(1):41-57. doi: 10.1080/15287390903248901.

PMID:
19953419
15.

Close functional coupling between Ca2+ release-activated Ca2+ channels and reactive oxygen species production in murine macrophages.

Jin SW, Zhang L, Lian QQ, Yao SL, Wu P, Zhou XY, Xiong W, Ye DY.

Mediators Inflamm. 2006;2006(6):36192.

16.

Ultrafine particulate matter impairs mitochondrial redox homeostasis and activates phosphatidylinositol 3-kinase mediated DNA damage responses in lymphocytes.

Bhargava A, Tamrakar S, Aglawe A, Lad H, Srivastava RK, Mishra DK, Tiwari R, Chaudhury K, Goryacheva IY, Mishra PK.

Environ Pollut. 2018 Mar;234:406-419. doi: 10.1016/j.envpol.2017.11.093. Epub 2017 Dec 1.

PMID:
29202419
17.

Ambient air pollution and thrombosis.

Robertson S, Miller MR.

Part Fibre Toxicol. 2018 Jan 3;15(1):1. doi: 10.1186/s12989-017-0237-x. Review.

18.

Household air pollution causes dose-dependent inflammation and altered phagocytosis in human macrophages.

Rylance J, Fullerton DG, Scriven J, Aljurayyan AN, Mzinza D, Barrett S, Wright AK, Wootton DG, Glennie SJ, Baple K, Knott A, Mortimer K, Russell DG, Heyderman RS, Gordon SB.

Am J Respir Cell Mol Biol. 2015 May;52(5):584-93. doi: 10.1165/rcmb.2014-0188OC.

19.

The energy disruptor metformin targets mitochondrial integrity via modification of calcium flux in cancer cells.

Loubiere C, Clavel S, Gilleron J, Harisseh R, Fauconnier J, Ben-Sahra I, Kaminski L, Laurent K, Herkenne S, Lacas-Gervais S, Ambrosetti D, Alcor D, Rocchi S, Cormont M, Michiels JF, Mari B, Mazure NM, Scorrano L, Lacampagne A, Gharib A, Tanti JF, Bost F.

Sci Rep. 2017 Jul 11;7(1):5040. doi: 10.1038/s41598-017-05052-2.

20.

Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis.

Soberanes S, Misharin AV, Jairaman A, Morales-Nebreda L, McQuattie-Pimentel AC, Cho T, Hamanaka RB, Meliton AY, Reyfman PA, Walter JM, Chen CI, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Antalek M, Abdala-Valencia H, Chiarella SE, Sun KA, Woods PS, Ghio AJ, Jain M, Perlman H, Ridge KM, Morimoto RI, Sznajder JI, Balch WE, Bhorade SM, Bharat A, Prakriya M, Chandel NS, Mutlu GM, Budinger GRS.

Cell Metab. 2019 Feb 5;29(2):503. doi: 10.1016/j.cmet.2018.12.001. No abstract available.

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