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Items: 1 to 20 of 95

1.

IL-17 integrates multiple self-reinforcing, feed-forward mechanisms through the RNA binding protein Arid5a.

Amatya N, Childs EE, Cruz JA, Aggor FEY, Garg AV, Berman AJ, Gudjonsson JE, Atasoy U, Gaffen SL.

Sci Signal. 2018 Oct 9;11(551). pii: eaat4617. doi: 10.1126/scisignal.aat4617.

PMID:
30301788
2.

Arid5a stabilizes OX40 mRNA in murine CD4+ T cells by recognizing a stem-loop structure in its 3'UTR.

Hanieh H, Masuda K, Metwally H, Chalise JP, Mohamed M, Nyati KK, Standley DM, Li S, Higa M, Zaman MM, Kishimoto T.

Eur J Immunol. 2018 Apr;48(4):593-604. doi: 10.1002/eji.201747109. Epub 2018 Feb 5.

3.

TLR4-induced NF-κB and MAPK signaling regulate the IL-6 mRNA stabilizing protein Arid5a.

Nyati KK, Masuda K, Zaman MM, Dubey PK, Millrine D, Chalise JP, Higa M, Li S, Standley DM, Saito K, Hanieh H, Kishimoto T.

Nucleic Acids Res. 2017 Mar 17;45(5):2687-2703. doi: 10.1093/nar/gkx064.

4.

Arid5a controls IL-6 mRNA stability, which contributes to elevation of IL-6 level in vivo.

Masuda K, Ripley B, Nishimura R, Mino T, Takeuchi O, Shioi G, Kiyonari H, Kishimoto T.

Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9409-14. doi: 10.1073/pnas.1307419110. Epub 2013 May 15.

5.

A Potential Therapeutic Target RNA-binding Protein, Arid5a for the Treatment of Inflammatory Disease Associated with Aberrant Cytokine Expression.

Masuda K, Kishimoto T.

Curr Pharm Des. 2018;24(16):1766-1771. doi: 10.2174/1381612824666180426103753.

PMID:
29701145
6.

MCPIP1 Endoribonuclease Activity Negatively Regulates Interleukin-17-Mediated Signaling and Inflammation.

Garg AV, Amatya N, Chen K, Cruz JA, Grover P, Whibley N, Conti HR, Hernandez Mir G, Sirakova T, Childs EC, Smithgall TE, Biswas PS, Kolls JK, McGeachy MJ, Kolattukudy PE, Gaffen SL.

Immunity. 2015 Sep 15;43(3):475-87. doi: 10.1016/j.immuni.2015.07.021. Epub 2015 Aug 25.

7.

Endonuclease Regnase-1/Monocyte chemotactic protein-1-induced protein-1 (MCPIP1) in controlling immune responses and beyond.

Takeuchi O.

Wiley Interdiscip Rev RNA. 2018 Jan;9(1). doi: 10.1002/wrna.1449. Epub 2017 Sep 20. Review.

PMID:
28929622
8.

Arid5a-deficient mice are highly resistant to bleomycin-induced lung injury.

Dubey PK, Masuda K, Nyati KK, -Uz Zaman MM, Chalise JP, Millrine D, Kai W, Ripley B, Kishimoto T.

Int Immunol. 2017 Feb 1;29(2):79-85. doi: 10.1093/intimm/dxx004.

PMID:
28379390
9.

mRNA degradation by the endoribonuclease Regnase-1/ZC3H12a/MCPIP-1.

Uehata T, Akira S.

Biochim Biophys Acta. 2013 Jun-Jul;1829(6-7):708-13. doi: 10.1016/j.bbagrm.2013.03.001. Epub 2013 Mar 13. Review.

PMID:
23500036
10.

MCPIP1/Regnase-1 Restricts IL-17A- and IL-17C-Dependent Skin Inflammation.

Monin L, Gudjonsson JE, Childs EE, Amatya N, Xing X, Verma AH, Coleman BM, Garg AV, Killeen M, Mathers A, Ward NL, Gaffen SL.

J Immunol. 2017 Jan 15;198(2):767-775. doi: 10.4049/jimmunol.1601551. Epub 2016 Dec 5.

11.

Arid5a cooperates with Sox9 to stimulate chondrocyte-specific transcription.

Amano K, Hata K, Muramatsu S, Wakabayashi M, Takigawa Y, Ono K, Nakanishi M, Takashima R, Kogo M, Matsuda A, Nishimura R, Yoneda T.

Mol Biol Cell. 2011 Apr 15;22(8):1300-11. doi: 10.1091/mbc.E10-07-0566. Epub 2011 Feb 23.

12.

Interleukin-17 (IL-17) and IL-1 activate translation of overlapping sets of mRNAs, including that of the negative regulator of inflammation, MCPIP1.

Dhamija S, Winzen R, Doerrie A, Behrens G, Kuehne N, Schauerte C, Neumann E, Dittrich-Breiholz O, Kracht M, Holtmann H.

J Biol Chem. 2013 Jun 28;288(26):19250-9. doi: 10.1074/jbc.M113.452649. Epub 2013 May 8.

13.

Regulation of inflammatory responses by dynamic subcellular localization of RNA-binding protein Arid5a.

Higa M, Oka M, Fujihara Y, Masuda K, Yoneda Y, Kishimoto T.

Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):E1214-E1220. doi: 10.1073/pnas.1719921115. Epub 2018 Jan 22.

14.

Arid5a regulates naive CD4+ T cell fate through selective stabilization of Stat3 mRNA.

Masuda K, Ripley B, Nyati KK, Dubey PK, Zaman MM, Hanieh H, Higa M, Yamashita K, Standley DM, Mashima T, Katahira M, Okamoto T, Matsuura Y, Takeuchi O, Kishimoto T.

J Exp Med. 2016 Apr 4;213(4):605-19. doi: 10.1084/jem.20151289. Epub 2016 Mar 28.

15.

A translational silencing function of MCPIP1/Regnase-1 specified by the target site context.

Behrens G, Winzen R, Rehage N, Dörrie A, Barsch M, Hoffmann A, Hackermüller J, Tiedje C, Heissmeyer V, Holtmann H.

Nucleic Acids Res. 2018 May 4;46(8):4256-4270. doi: 10.1093/nar/gky106.

16.

Arid5a makes the IL-17A/F-responsive pathway less arid.

Puel A, Casanova JL.

Sci Signal. 2018 Oct 9;11(551). pii: eaau8876. doi: 10.1126/scisignal.aau8876. Review.

PMID:
30301789
17.

The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1.

Iwasaki H, Takeuchi O, Teraguchi S, Matsushita K, Uehata T, Kuniyoshi K, Satoh T, Saitoh T, Matsushita M, Standley DM, Akira S.

Nat Immunol. 2011 Oct 30;12(12):1167-75. doi: 10.1038/ni.2137.

PMID:
22037600
18.

IL-6: A New Era for the Treatment of Autoimmune Inflammatory Diseases.

Kishimoto T, Kang S, Tanaka T.

In: Nakao K, Minato N, Uemoto S, editors. Innovative Medicine: Basic Research and Development [Internet]. Tokyo: Springer; 2015.

19.

Interleukin-1 activates synthesis of interleukin-6 by interfering with a KH-type splicing regulatory protein (KSRP)-dependent translational silencing mechanism.

Dhamija S, Kuehne N, Winzen R, Doerrie A, Dittrich-Breiholz O, Thakur BK, Kracht M, Holtmann H.

J Biol Chem. 2011 Sep 23;286(38):33279-88. doi: 10.1074/jbc.M111.264754. Epub 2011 Jul 27.

20.

IκBζ is a key transcriptional regulator of IL-36-driven psoriasis-related gene expression in keratinocytes.

Müller A, Hennig A, Lorscheid S, Grondona P, Schulze-Osthoff K, Hailfinger S, Kramer D.

Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):10088-10093. doi: 10.1073/pnas.1801377115. Epub 2018 Sep 17.

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