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Items: 1 to 20 of 88

1.

Copper-Catalyzed Syntheses of Pyrene-Pyrazole Pharmacophores and Structure Activity Studies for Tubulin Polymerization.

Sar D, Srivastava I, Misra SK, Ostadhossein F, Fathi P, Pan D.

ACS Omega. 2018 Jun 30;3(6):6378-6387. doi: 10.1021/acsomega.8b00320. Epub 2018 Jun 13.

2.

Drug-Clinical Agent Molecular Hybrid: Synthesis of Diaryl(trifluoromethyl)pyrazoles as Tubulin Targeting Anticancer Agents.

Hura N, Naaz A, Prassanawar SS, Guchhait SK, Panda D.

ACS Omega. 2018 Feb 28;3(2):1955-1969. doi: 10.1021/acsomega.7b01784. Epub 2018 Feb 19.

3.

Design and synthesis of pyrazole/isoxazole linked arylcinnamides as tubulin polymerization inhibitors and potential antiproliferative agents.

Kamal A, Shaik AB, Rao BB, Khan I, Bharath Kumar G, Jain N.

Org Biomol Chem. 2015 Oct 28;13(40):10162-78. doi: 10.1039/c5ob01257k. Epub 2015 Aug 25.

PMID:
26303171
4.

Pyrazole-oxadiazole conjugates: synthesis, antiproliferative activity and inhibition of tubulin polymerization.

Kamal A, Shaik AB, Polepalli S, Reddy VS, Kumar GB, Gupta S, Krishna KV, Nagabhushana A, Mishra RK, Jain N.

Org Biomol Chem. 2014 Oct 28;12(40):7993-8007. doi: 10.1039/c4ob01152j.

PMID:
25181296
5.

Design and synthesis of pyrazole-oxindole conjugates targeting tubulin polymerization as new anticancer agents.

Kamal A, Shaik AB, Jain N, Kishor C, Nagabhushana A, Supriya B, Bharath Kumar G, Chourasiya SS, Suresh Y, Mishra RK, Addlagatta A.

Eur J Med Chem. 2015 Mar 6;92:501-13. doi: 10.1016/j.ejmech.2013.10.077. Epub 2013 Nov 8.

PMID:
25599948
6.

Synthesis of arylpyrazole linked benzimidazole conjugates as potential microtubule disruptors.

Kamal A, Shaik AB, Polepalli S, Kumar GB, Reddy VS, Mahesh R, Garimella S, Jain N.

Bioorg Med Chem. 2015 Mar 1;23(5):1082-95. doi: 10.1016/j.bmc.2015.01.004. Epub 2015 Jan 8.

PMID:
25648686
7.

Synthesis, biological evaluation and molecular docking of benzimidazole grafted benzsulfamide-containing pyrazole ring derivatives as novel tubulin polymerization inhibitors.

Wang YT, Shi TQ, Zhu HL, Liu CH.

Bioorg Med Chem. 2019 Feb 1;27(3):502-515. doi: 10.1016/j.bmc.2018.12.031. Epub 2018 Dec 23.

PMID:
30606674
8.

Synthesis and Biological Evaluation of 1-Methyl-1H-indole-Pyrazoline Hybrids as Potential Tubulin Polymerization Inhibitors.

Zhang YL, Qin YJ, Tang DJ, Yang MR, Li BY, Wang YT, Cai HY, Wang BZ, Zhu HL.

ChemMedChem. 2016 Jul 5;11(13):1446-58. doi: 10.1002/cmdc.201600137. Epub 2016 May 9.

PMID:
27159418
9.

Design, synthesis, and biological evaluation of novel combretastatin A-4 thio derivatives as microtubule targeting agents.

Stefański T, Mikstacka R, Kurczab R, Dutkiewicz Z, Kucińska M, Murias M, Zielińska-Przyjemska M, Cichocki M, Teubert A, Kaczmarek M, Hogendorf A, Sobiak S.

Eur J Med Chem. 2018 Jan 20;144:797-816. doi: 10.1016/j.ejmech.2017.11.050. Epub 2017 Dec 12.

PMID:
29291446
10.

Design and synthesis of bis(indolyl)ketohydrazide-hydrazones: Identification of potent and selective novel tubulin inhibitors.

Tantak MP, Klingler L, Arun V, Kumar A, Sadana R, Kumar D.

Eur J Med Chem. 2017 Aug 18;136:184-194. doi: 10.1016/j.ejmech.2017.04.078. Epub 2017 May 3.

PMID:
28494255
11.

Synthesis of (Z)-(arylamino)-pyrazolyl/isoxazolyl-2-propenones as tubulin targeting anticancer agents and apoptotic inducers.

Kamal A, Reddy VS, Shaik AB, Kumar GB, Vishnuvardhan MV, Polepalli S, Jain N.

Org Biomol Chem. 2015 Mar 21;13(11):3416-31. doi: 10.1039/c4ob02449d.

PMID:
25661328
12.

Arsenic trioxide produces polymerization of microtubules and mitotic arrest before apoptosis in human tumor cell lines.

Ling YH, Jiang JD, Holland JF, Perez-Soler R.

Mol Pharmacol. 2002 Sep;62(3):529-38.

PMID:
12181429
13.

Hybrid Pharmacophore Design, Molecular Docking, Synthesis, and Biological Evaluation of Novel Aldimine-Type Schiff Base Derivatives as Tubulin Polymerization Inhibitor.

Ameri A, Khodarahmi G, Forootanfar H, Hassanzadeh F, Hakimelahi GH.

Chem Biodivers. 2018 Mar;15(3):e1700518. doi: 10.1002/cbdv.201700518. Epub 2018 Mar 7.

PMID:
29292595
14.

Design, Synthesis and Molecular Docking Studies of Novel Indole-Pyrimidine Hybrids as Tubulin Polymerization Inhibitors.

Hu MJ, Zhang B, Yang HK, Liu Y, Chen YR, Ma TZ, Lu L, You WW, Zhao PL.

Chem Biol Drug Des. 2015 Dec;86(6):1491-500. doi: 10.1111/cbdd.12616. Epub 2015 Aug 3.

PMID:
26177395
15.

Synthesis, cytotoxicity, docking study, and tubulin polymerization inhibitory activity of novel 1-(3,4-dimethoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazole-3-carboxanilides.

Aly OM, Beshr EA, Maklad RM, Mustafa M, Gamal-Eldeen AM.

Arch Pharm (Weinheim). 2014 Sep;347(9):658-67. doi: 10.1002/ardp.201400096. Epub 2014 Jul 3.

PMID:
24996189
16.

Synthesis and evaluation of N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)nicotinamides as potential anticancer agents that inhibit tubulin polymerization.

Kamal A, Reddy NV, Nayak VL, Bolla NR, Subba Rao AV, Prasad B.

Bioorg Med Chem. 2014 Jul 1;22(13):3465-77. doi: 10.1016/j.bmc.2014.04.038. Epub 2014 Apr 28.

PMID:
24835786
17.

Design, Synthesis, and Biological Evaluation of 1-Methyl-1,4-dihydroindeno[1,2-c]pyrazole Analogues as Potential Anticancer Agents Targeting Tubulin Colchicine Binding Site.

Liu YN, Wang JJ, Ji YT, Zhao GD, Tang LQ, Zhang CM, Guo XL, Liu ZP.

J Med Chem. 2016 Jun 9;59(11):5341-55. doi: 10.1021/acs.jmedchem.6b00071. Epub 2016 May 20.

PMID:
27172319
18.

Design, synthesis and biological evaluation of 1, 4-dihydro indeno[1,2-c] pyrazole linked oxindole analogues as potential anticancer agents targeting tubulin and inducing p53 dependent apoptosis.

Khan I, Garikapati KR, Shaik AB, Makani VKK, Rahim A, Shareef MA, Reddy VG, Pal-Bhadra M, Kamal A, Kumar CG.

Eur J Med Chem. 2018 Jan 20;144:104-115. doi: 10.1016/j.ejmech.2017.12.010. Epub 2017 Dec 5.

PMID:
29268127
19.

Autophagic cell death, polyploidy and senescence induced in breast tumor cells by the substituted pyrrole JG-03-14, a novel microtubule poison.

Arthur CR, Gupton JT, Kellogg GE, Yeudall WA, Cabot MC, Newsham IF, Gewirtz DA.

Biochem Pharmacol. 2007 Oct 1;74(7):981-91. Epub 2007 Jul 7.

20.

1,3,4-oxadiazole-2-thione Derivatives; Novel Approach for Anticancer and Tubulin Polymerization Inhibitory Activities.

Abdel-Aziz M, Metwally KA, Gamal-Eldeen AM, Aly OM.

Anticancer Agents Med Chem. 2015;16(2):269-77.

PMID:
26343141

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