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Interdependence between EGFR and Phosphatases Spatially Established by Vesicular Dynamics Generates a Growth Factor Sensing and Responding Network.

Stanoev A, Mhamane A, Schuermann KC, Grecco HE, Stallaert W, Baumdick M, Brüggemann Y, Joshi MS, Roda-Navarro P, Fengler S, Stockert R, Roßmannek L, Luig J, Koseska A, Bastiaens PIH.

Cell Syst. 2018 Sep 26;7(3):295-309.e11. doi: 10.1016/j.cels.2018.06.006. Epub 2018 Aug 22.


EGF-dependent re-routing of vesicular recycling switches spontaneous phosphorylation suppression to EGFR signaling.

Baumdick M, Brüggemann Y, Schmick M, Xouri G, Sabet O, Davis L, Chin JW, Bastiaens PI.

Elife. 2015 Nov 26;4. pii: e12223. doi: 10.7554/eLife.12223.


Activation of the EGFR/p38/JNK pathway by mitochondrial-derived hydrogen peroxide contributes to oxygen-induced contraction of ductus arteriosus.

Hong Z, Cabrera JA, Mahapatra S, Kutty S, Weir EK, Archer SL.

J Mol Med (Berl). 2014 Sep;92(9):995-1007. doi: 10.1007/s00109-014-1162-1. Epub 2014 Jun 8.


Growth hormone alters epidermal growth factor receptor binding affinity via activation of extracellular signal-regulated kinases in 3T3-F442A cells.

Huang Y, Chang Y, Wang X, Jiang J, Frank SJ.

Endocrinology. 2004 Jul;145(7):3297-306. Epub 2004 Apr 7.


Dynamic recruitment of protein tyrosine phosphatase PTPD1 to EGF stimulation sites potentiates EGFR activation.

Roda-Navarro P, Bastiaens PI.

PLoS One. 2014 Jul 25;9(7):e103203. doi: 10.1371/journal.pone.0103203. eCollection 2014.


Contact inhibitory Eph signaling suppresses EGF-promoted cell migration by decoupling EGFR activity from vesicular recycling.

Stallaert W, Brüggemann Y, Sabet O, Baak L, Gattiglio M, Bastiaens PIH.

Sci Signal. 2018 Jul 31;11(541). pii: eaat0114. doi: 10.1126/scisignal.aat0114.


Loss of protein tyrosine phosphatase N2 potentiates epidermal growth factor suppression of intestinal epithelial chloride secretion.

Scharl M, Rudenko I, McCole DF.

Am J Physiol Gastrointest Liver Physiol. 2010 Oct;299(4):G935-45. doi: 10.1152/ajpgi.00106.2010. Epub 2010 Aug 5.


Re-localization of activated EGF receptor and its signal transducers to multivesicular compartments downstream of early endosomes in response to EGF.

Oksvold MP, Skarpen E, Wierød L, Paulsen RE, Huitfeldt HS.

Eur J Cell Biol. 2001 Apr;80(4):285-94.


Protein tyrosine phosphatases as novel targets in breast cancer therapy.

Nunes-Xavier CE, Martín-Pérez J, Elson A, Pulido R.

Biochim Biophys Acta. 2013 Dec;1836(2):211-26. doi: 10.1016/j.bbcan.2013.06.001. Epub 2013 Jun 10. Review.


Epidermal growth factor receptor phosphorylation sites Ser991 and Tyr998 are implicated in the regulation of receptor endocytosis and phosphorylations at Ser1039 and Thr1041.

Tong J, Taylor P, Peterman SM, Prakash A, Moran MF.

Mol Cell Proteomics. 2009 Sep;8(9):2131-44. doi: 10.1074/mcp.M900148-MCP200. Epub 2009 Jun 15.


EGFR activation coupled to inhibition of tyrosine phosphatases causes lateral signal propagation.

Reynolds AR, Tischer C, Verveer PJ, Rocks O, Bastiaens PI.

Nat Cell Biol. 2003 May;5(5):447-53.


Priming with EGFR tyrosine kinase inhibitor and EGF sensitizes ovarian cancer cells to respond to chemotherapeutical drugs.

Cao C, Lu S, Sowa A, Kivlin R, Amaral A, Chu W, Yang H, Di W, Wan Y.

Cancer Lett. 2008 Aug 8;266(2):249-62. doi: 10.1016/j.canlet.2008.02.062. Epub 2008 Apr 8.


EGFR-SGLT1 interaction does not respond to EGFR modulators, but inhibition of SGLT1 sensitizes prostate cancer cells to EGFR tyrosine kinase inhibitors.

Ren J, Bollu LR, Su F, Gao G, Xu L, Huang WC, Hung MC, Weihua Z.

Prostate. 2013 Sep;73(13):1453-61. doi: 10.1002/pros.22692. Epub 2013 Jun 14.


Computational analysis of the regulation of EGFR by protein tyrosine phosphatases.

Monast CS, Furcht CM, Lazzara MJ.

Biophys J. 2012 May 2;102(9):2012-21. doi: 10.1016/j.bpj.2012.03.037.


Prolonged EGFR signaling by ERBB2-mediated sequestration at the plasma membrane.

Offterdinger M, Bastiaens PI.

Traffic. 2008 Jan;9(1):147-55. Epub 2007 Nov 13.


Essential role of c-Cbl in amphiregulin-induced recycling and signaling of the endogenous epidermal growth factor receptor.

Baldys A, Göoz M, Morinelli TA, Lee MH, Raymond JR Jr, Luttrell LM, Raymond JR Sr.

Biochemistry. 2009 Feb 24;48(7):1462-73. doi: 10.1021/bi801771g.

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