Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 99

1.

2,4-Dimethylaniline generates phosphorylated histone H2AX in human urothelial and hepatic cells through reactive oxygen species produced by cytochrome P450 2E1.

Qi Y, Toyooka T, Kashiwagi H, Yanagiba Y, Koda S, Ohta H, Wang RS.

Arch Toxicol. 2018 Oct;92(10):3093-3101. doi: 10.1007/s00204-018-2289-6. Epub 2018 Aug 21.

PMID:
30132044
2.

Trichloroethylene exposure results in the phosphorylation of histone H2AX in a human hepatic cell line through cytochrome P450 2E1-mediated oxidative stress.

Toyooka T, Yanagiba Y, Ibuki Y, Wang RS.

J Appl Toxicol. 2018 Sep;38(9):1224-1232. doi: 10.1002/jat.3632. Epub 2018 May 3.

PMID:
29722447
3.

1,2-Dichloropropane generates phosphorylated histone H2AX via cytochrome P450 2E1-mediated metabolism.

Toyooka T, Yanagiba Y, Suda M, Ibuki Y, Wang RS.

Toxicol Lett. 2017 Apr 15;272:60-67. doi: 10.1016/j.toxlet.2017.03.009. Epub 2017 Mar 12.

PMID:
28300663
4.

Genotoxicity of 2,6- and 3,5-dimethylaniline in cultured mammalian cells: the role of reactive oxygen species.

Chao MW, Kim MY, Ye W, Ge J, Trudel LJ, Belanger CL, Skipper PL, Engelward BP, Tannenbaum SR, Wogan GN.

Toxicol Sci. 2012 Nov;130(1):48-59. doi: 10.1093/toxsci/kfs229. Epub 2012 Jul 24.

5.

Cigarette sidestream smoke induces phosphorylated histone H2AX.

Toyooka T, Ibuki Y.

Mutat Res. 2009 May 31;676(1-2):34-40. doi: 10.1016/j.mrgentox.2009.03.002. Epub 2009 Mar 27.

PMID:
19486862
6.

Early Detection of Genotoxic Urinary Bladder Carcinogens by Immunohistochemistry for γ-H2AX.

Toyoda T, Cho YM, Akagi J, Mizuta Y, Hirata T, Nishikawa A, Ogawa K.

Toxicol Sci. 2015 Dec;148(2):400-8. doi: 10.1093/toxsci/kfv192. Epub 2015 Sep 3.

PMID:
26338220
7.
8.

Immunohistochemistry of γ-H2AX as a method of early detection of urinary bladder carcinogenicity in mice.

Sone M, Toyoda T, Cho YM, Akagi JI, Matsushita K, Mizuta Y, Morikawa T, Nishikawa A, Ogawa K.

J Appl Toxicol. 2019 Jan 31. doi: 10.1002/jat.3775. [Epub ahead of print]

PMID:
30701581
9.

Oxidation of 2,6-dimethylaniline by recombinant human cytochrome P450s and human liver microsomes.

Gan J, Skipper PL, Tannenbaum SR.

Chem Res Toxicol. 2001 Jun;14(6):672-7.

PMID:
11409937
10.

Identification of adducts formed by reaction of N-acetoxy-3,5-dimethylaniline with DNA.

Cui L, Sun HL, Wishnok JS, Tannenbaum SR, Skipper PL.

Chem Res Toxicol. 2007 Nov;20(11):1730-6.

11.

Hepatitis C virus core protein, cytochrome P450 2E1, and alcohol produce combined mitochondrial injury and cytotoxicity in hepatoma cells.

Otani K, Korenaga M, Beard MR, Li K, Qian T, Showalter LA, Singh AK, Wang T, Weinman SA.

Gastroenterology. 2005 Jan;128(1):96-107.

PMID:
15633127
12.

Generation of phosphorylated histone H2AX by benzene metabolites.

Ishihama M, Toyooka T, Ibuki Y.

Toxicol In Vitro. 2008 Dec;22(8):1861-8. doi: 10.1016/j.tiv.2008.09.005. Epub 2008 Sep 18.

PMID:
18835433
13.

UVB irradiation changes genotoxic potential of nonylphenolpolyethoxylates--remarkable generation of γ-H2AX with degradation of chemical structure.

Toyooka T, Kubota T, Ibuki Y.

Mutagenesis. 2013 Jan;28(1):7-14. doi: 10.1093/mutage/ges043. Epub 2012 Sep 17.

PMID:
22987026
14.

Extent of constitutive histone H2AX phosphorylation on Ser-139 varies in cells with different TP53 status.

Tanaka T, Kurose A, Huang X, Traganos F, Dai W, Darzynkiewicz Z.

Cell Prolif. 2006 Aug;39(4):313-23.

PMID:
16872365
16.

Nonylphenol polyethoxylates induce phosphorylation of histone H2AX.

Toyooka T, Kubota T, Ibuki Y.

Mutat Res. 2012 Jan 24;741(1-2):57-64. doi: 10.1016/j.mrgentox.2011.10.006. Epub 2011 Oct 24.

PMID:
22051700
17.

Evaluation of N-acetyl-cysteine against tetrachlorobenzoquinone-induced genotoxicity and oxidative stress in HepG2 cells.

Dong H, Xu D, Hu L, Li L, Song E, Song Y.

Food Chem Toxicol. 2014 Feb;64:291-7. doi: 10.1016/j.fct.2013.11.036. Epub 2013 Dec 2.

PMID:
24309147
18.

Solar-simulated light-exposed benzo[a]pyrene induces phosphorylation of histone H2AX.

Toyooka T, Ohnuki G, Ibuki Y.

Mutat Res. 2008 Feb 29;650(2):132-9. Epub 2007 Nov 19.

PMID:
18160332
19.

Protective effects of ascorbic acid against the genetic and epigenetic alterations induced by 3,5-dimethylaminophenol in AA8 cells.

Chao MW, Erkekoglu P, Tseng CY, Ye W, Trudel LJ, Skipper PL, Tannenbaum SR, Wogan GN.

J Appl Toxicol. 2015 May;35(5):466-77. doi: 10.1002/jat.3046. Epub 2014 Sep 1.

20.

Clinical isoflurane metabolism by cytochrome P450 2E1.

Kharasch ED, Hankins DC, Cox K.

Anesthesiology. 1999 Mar;90(3):766-71.

PMID:
10078678

Supplemental Content

Support Center