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Items: 1 to 20 of 100

1.

mTORC1 and IRS1: Another Deadly Kiss.

Ardestani A, Maedler K.

Trends Endocrinol Metab. 2018 Nov;29(11):737-739. doi: 10.1016/j.tem.2018.07.003. Epub 2018 Aug 3.

PMID:
30082207
2.

Chronic inhibition of the mTORC1/S6K1 pathway increases insulin-induced PI3K activity but inhibits Akt2 and glucose transport stimulation in 3T3-L1 adipocytes.

Veilleux A, Houde VP, Bellmann K, Marette A.

Mol Endocrinol. 2010 Apr;24(4):766-78. doi: 10.1210/me.2009-0328. Epub 2010 Mar 4.

3.

Hypoxia Increases IGFBP-1 Phosphorylation Mediated by mTOR Inhibition.

Damerill I, Biggar KK, Abu Shehab M, Li SS, Jansson T, Gupta MB.

Mol Endocrinol. 2016 Feb;30(2):201-16. doi: 10.1210/me.2015-1194. Epub 2015 Dec 29.

4.

The Role of Mammalian Target of Rapamycin (mTOR) in Insulin Signaling.

Yoon MS.

Nutrients. 2017 Oct 27;9(11). pii: E1176. doi: 10.3390/nu9111176. Review.

5.

Regulation of insulin receptor substrate-1 by mTORC2 (mammalian target of rapamycin complex 2).

Destefano MA, Jacinto E.

Biochem Soc Trans. 2013 Aug;41(4):896-901. doi: 10.1042/BST20130018. Review.

6.

Serine Phosphorylation by mTORC1 Promotes IRS-1 Degradation through SCFβ-TRCP E3 Ubiquitin Ligase.

Yoneyama Y, Inamitsu T, Chida K, Iemura SI, Natsume T, Maeda T, Hakuno F, Takahashi SI.

iScience. 2018 Jul 27;5:1-18. doi: 10.1016/j.isci.2018.06.006. Epub 2018 Jun 18.

7.

Discrete signaling mechanisms of mTORC1 and mTORC2: Connected yet apart in cellular and molecular aspects.

Jhanwar-Uniyal M, Amin AG, Cooper JB, Das K, Schmidt MH, Murali R.

Adv Biol Regul. 2017 May;64:39-48. doi: 10.1016/j.jbior.2016.12.001. Epub 2017 Jan 4. Review.

PMID:
28189457
8.

Serine 302 Phosphorylation of Mouse Insulin Receptor Substrate 1 (IRS1) Is Dispensable for Normal Insulin Signaling and Feedback Regulation by Hepatic S6 Kinase.

Copps KD, Hançer NJ, Qiu W, White MF.

J Biol Chem. 2016 Apr 15;291(16):8602-17. doi: 10.1074/jbc.M116.714915. Epub 2016 Feb 4.

9.

RhoA modulates signaling through the mechanistic target of rapamycin complex 1 (mTORC1) in mammalian cells.

Gordon BS, Kazi AA, Coleman CS, Dennis MD, Chau V, Jefferson LS, Kimball SR.

Cell Signal. 2014 Mar;26(3):461-7. doi: 10.1016/j.cellsig.2013.11.035. Epub 2013 Dec 3.

10.

Mechanistic Target of Rapamycin Complex 1 (mTORC1) and mTORC2 as Key Signaling Intermediates in Mesenchymal Cell Activation.

Walker NM, Belloli EA, Stuckey L, Chan KM, Lin J, Lynch W, Chang A, Mazzoni SM, Fingar DC, Lama VN.

J Biol Chem. 2016 Mar 18;291(12):6262-71. doi: 10.1074/jbc.M115.672170. Epub 2016 Jan 11.

11.

Identification of the degradation determinants of insulin receptor substrate 1 for signaling cullin-RING E3 ubiquitin ligase 7-mediated ubiquitination.

Xu X, Keshwani M, Meyer K, Sarikas A, Taylor S, Pan ZQ.

J Biol Chem. 2012 Nov 23;287(48):40758-66. doi: 10.1074/jbc.M112.405209. Epub 2012 Oct 8.

12.

Targeted Inhibition of Rictor/mTORC2 in Cancer Treatment: A New Era after Rapamycin.

Zou Z, Chen J, Yang J, Bai X.

Curr Cancer Drug Targets. 2016;16(4):288-304. Review.

PMID:
26563881
13.

mTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of action.

Soliman GA, Acosta-Jaquez HA, Dunlop EA, Ekim B, Maj NE, Tee AR, Fingar DC.

J Biol Chem. 2010 Mar 12;285(11):7866-79. doi: 10.1074/jbc.M109.096222. Epub 2009 Dec 18.

14.

mTORC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTOR.

Yin Y, Hua H, Li M, Liu S, Kong Q, Shao T, Wang J, Luo Y, Wang Q, Luo T, Jiang Y.

Cell Res. 2016 Jan;26(1):46-65. doi: 10.1038/cr.2015.133. Epub 2015 Nov 20.

15.

Distinct signaling mechanisms of mTORC1 and mTORC2 in glioblastoma multiforme: a tale of two complexes.

Jhanwar-Uniyal M, Gillick JL, Neil J, Tobias M, Thwing ZE, Murali R.

Adv Biol Regul. 2015 Jan;57:64-74. doi: 10.1016/j.jbior.2014.09.004. Epub 2014 Sep 18.

PMID:
25442674
16.

mTORC2 (Rictor) in Alzheimer's Disease and Reversal of Amyloid-β Expression-Induced Insulin Resistance and Toxicity in Rat Primary Cortical Neurons.

Lee HK, Kwon B, Lemere CA, de la Monte S, Itamura K, Ha AY, Querfurth HW.

J Alzheimers Dis. 2017;56(3):1015-1036. doi: 10.3233/JAD-161029.

17.

Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2.

Ye L, Varamini B, Lamming DW, Sabatini DM, Baur JA.

Front Genet. 2012 Sep 11;3:177. doi: 10.3389/fgene.2012.00177. eCollection 2012.

18.

Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway.

Zhang HH, Huang J, Düvel K, Boback B, Wu S, Squillace RM, Wu CL, Manning BD.

PLoS One. 2009 Jul 10;4(7):e6189. doi: 10.1371/journal.pone.0006189.

19.

Feedback mechanisms promote cooperativity for small molecule inhibitors of epidermal and insulin-like growth factor receptors.

Buck E, Eyzaguirre A, Rosenfeld-Franklin M, Thomson S, Mulvihill M, Barr S, Brown E, O'Connor M, Yao Y, Pachter J, Miglarese M, Epstein D, Iwata KK, Haley JD, Gibson NW, Ji QS.

Cancer Res. 2008 Oct 15;68(20):8322-32. doi: 10.1158/0008-5472.CAN-07-6720.

20.

Alpha-synuclein overexpression negatively regulates insulin receptor substrate 1 by activating mTORC1/S6K1 signaling.

Gao S, Duan C, Gao G, Wang X, Yang H.

Int J Biochem Cell Biol. 2015 Jul;64:25-33. doi: 10.1016/j.biocel.2015.03.006. Epub 2015 Mar 23.

PMID:
25813876

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