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Items: 1 to 20 of 107

1.

Bacterial supernatants elevate glucose-dependent insulin secretion in rat pancreatic INS-1 line and islet β-cells via PI3K/AKT signaling.

Ramenzoni LL, Zuellig RA, Hussain A, Lehmann R, Heumann C, Attin T, Schmidlin PR.

Mol Cell Biochem. 2019 Feb;452(1-2):17-27. doi: 10.1007/s11010-018-3408-7. Epub 2018 Jul 23.

2.

Akt signals upstream of L-type calcium channels to optimize insulin secretion.

Cui X, Yang G, Pan M, Zhang XN, Yang SN.

Pancreas. 2012 Jan;41(1):15-21. doi: 10.1097/MPA.0b013e31822363a9.

PMID:
21792084
3.

Glucotoxicity and α cell dysfunction: involvement of the PI3K/Akt pathway in glucose-induced insulin resistance in rat islets and clonal αTC1-6 cells.

Shen XX, Li HL, Pan L, Hong J, Xiao J, Hermansen K, Jeppesen PB, Li GW.

Endocr Res. 2012;37(1):12-24. doi: 10.3109/07435800.2011.610855. Epub 2011 Oct 18.

PMID:
22007944
4.

The role of phosphoinositide 3-kinase/Akt signaling in low-dose mercury-induced mouse pancreatic beta-cell dysfunction in vitro and in vivo.

Chen YW, Huang CF, Tsai KS, Yang RS, Yen CC, Yang CY, Lin-Shiau SY, Liu SH.

Diabetes. 2006 Jun;55(6):1614-24.

5.

Porphyromonas gingivalis lipopolysaccharide upregulates insulin secretion from pancreatic β cell line MIN6.

Bhat UG, Ilievski V, Unterman TG, Watanabe K.

J Periodontol. 2014 Nov;85(11):1629-36. doi: 10.1902/jop.2014.140070. Epub 2014 Jun 12.

6.

Effects of vaspin on pancreatic β cell secretion via PI3K/Akt and NF-κB signaling pathways.

Liu S, Li X, Wu Y, Duan R, Zhang J, Du F, Zhang Q, Li Y, Li N.

PLoS One. 2017 Dec 14;12(12):e0189722. doi: 10.1371/journal.pone.0189722. eCollection 2017.

7.

Acute inhibition of PI3K-PDK1-Akt pathway potentiates insulin secretion through upregulation of newcomer granule fusions in pancreatic β-cells.

Aoyagi K, Ohara-Imaizumi M, Nishiwaki C, Nakamichi Y, Ueki K, Kadowaki T, Nagamatsu S.

PLoS One. 2012;7(10):e47381. doi: 10.1371/journal.pone.0047381. Epub 2012 Oct 15.

8.

Nucleo-cytosolic shuttling of FoxO1 directly regulates mouse Ins2 but not Ins1 gene expression in pancreatic beta cells (MIN6).

Meur G, Qian Q, da Silva Xavier G, Pullen TJ, Tsuboi T, McKinnon C, Fletcher L, Tavaré JM, Hughes S, Johnson P, Rutter GA.

J Biol Chem. 2011 Apr 15;286(15):13647-56. doi: 10.1074/jbc.M110.204248. Epub 2011 Feb 18.

9.

Involvement of phosphatidylinositol-3 kinase/AKT/PKCzeta/lambda pathway in the effect of palmitate on glucose-induced insulin secretion.

Nogueira TC, Anhê GF, Carvalho CR, Curi R, Bordin S, Carpinelli AR.

Pancreas. 2008 Oct;37(3):309-15. doi: 10.1097/mpa.0b013e318168dac3.

PMID:
18815554
10.

Participation of prolactin receptors and phosphatidylinositol 3-kinase and MAP kinase pathways in the increase in pancreatic islet mass and sensitivity to glucose during pregnancy.

Amaral ME, Cunha DA, Anhê GF, Ueno M, Carneiro EM, Velloso LA, Bordin S, Boschero AC.

J Endocrinol. 2004 Dec;183(3):469-76.

PMID:
15590973
11.

Insulin-feedback via PI3K-C2alpha activated PKBalpha/Akt1 is required for glucose-stimulated insulin secretion.

Leibiger B, Moede T, Uhles S, Barker CJ, Creveaux M, Domin J, Berggren PO, Leibiger IB.

FASEB J. 2010 Jun;24(6):1824-37. doi: 10.1096/fj.09-148072. Epub 2010 Jan 8.

PMID:
20061534
12.

Dual functional effects of interleukin-1beta on purine nucleotides and insulin secretion in rat islets and INS-1 cells.

Meredith M, Rabaglia ME, Corbett JA, Metz SA.

Diabetes. 1996 Dec;45(12):1783-91.

PMID:
8922366
13.

Modulation of neuronal pentraxin 1 expression in rat pancreatic β-cells submitted to chronic glucotoxic stress.

Schvartz D, Couté Y, Brunner Y, Wollheim CB, Sanchez JC.

Mol Cell Proteomics. 2012 Aug;11(8):244-54. doi: 10.1074/mcp.M112.018051. Epub 2012 Mar 16.

14.

Atrial natriuretic peptide promotes pancreatic islet beta-cell growth and Akt/Foxo1a/cyclin D2 signaling.

You H, Laychock SG.

Endocrinology. 2009 Dec;150(12):5455-65. doi: 10.1210/en.2009-0468. Epub 2009 Oct 16.

PMID:
19837876
15.

Chronic hyperglycemia impairs insulin secretion by affecting insulin receptor expression, splicing, and signaling in RIN beta cell line and human islets of Langerhans.

Hribal ML, Perego L, Lovari S, Andreozzi F, Menghini R, Perego C, Finzi G, Usellini L, Placidi C, Capella C, Guzzi V, Lauro D, Bertuzzi F, Davalli A, Pozza G, Pontiroli A, Federici M, Lauro R, Brunetti A, Folli F, Sesti G.

FASEB J. 2003 Jul;17(10):1340-2. Epub 2003 May 8.

PMID:
12738810
16.

High glucose induces suppression of insulin signalling and apoptosis via upregulation of endogenous IL-1beta and suppressor of cytokine signalling-1 in mouse pancreatic beta cells.

Venieratos PD, Drossopoulou GI, Kapodistria KD, Tsilibary EC, Kitsiou PV.

Cell Signal. 2010 May;22(5):791-800. doi: 10.1016/j.cellsig.2010.01.003. Epub 2010 Jan 11.

PMID:
20067833
17.

Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic beta-cells and human islets: involvement of 3',5'-cyclic adenosine monophosphate/protein kinase A, extracellular signal-regulated kinase 1/2, and phosphatidyl inositol 3-Kinase/Akt signaling.

Granata R, Settanni F, Biancone L, Trovato L, Nano R, Bertuzzi F, Destefanis S, Annunziata M, Martinetti M, Catapano F, Ghè C, Isgaard J, Papotti M, Ghigo E, Muccioli G.

Endocrinology. 2007 Feb;148(2):512-29. Epub 2006 Oct 26.

PMID:
17068144
18.

TLR2/6 and TLR4-activated macrophages contribute to islet inflammation and impair beta cell insulin gene expression via IL-1 and IL-6.

Nackiewicz D, Dan M, He W, Kim R, Salmi A, Rütti S, Westwell-Roper C, Cunningham A, Speck M, Schuster-Klein C, Guardiola B, Maedler K, Ehses JA.

Diabetologia. 2014 Aug;57(8):1645-54. doi: 10.1007/s00125-014-3249-1. Epub 2014 May 12.

PMID:
24816367
19.

Insulin inhibits inflammation and promotes atherosclerotic plaque stability via PI3K-Akt pathway activation.

Yan H, Ma Y, Li Y, Zheng X, Lv P, Zhang Y, Li J, Ma M, Zhang L, Li C, Zhang R, Gao F, Wang H, Tao L.

Immunol Lett. 2016 Feb;170:7-14. doi: 10.1016/j.imlet.2015.12.003. Epub 2015 Dec 8.

PMID:
26681144
20.

Metallothionein induction in islets of Langerhans and insulinoma cells.

Laychock SG, Duzen J, Simpkins CO.

Mol Cell Endocrinol. 2000 Jul 25;165(1-2):179-87.

PMID:
10940496

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