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Effects of Phage Endolysin SAL200 Combined with Antibiotics on Staphylococcus aureus Infection.

Kim NH, Park WB, Cho JE, Choi YJ, Choi SJ, Jun SY, Kang CK, Song KH, Choe PG, Bang JH, Kim ES, Park SW, Kim NJ, Oh MD, Kim HB.

Antimicrob Agents Chemother. 2018 Sep 24;62(10). pii: e00731-18. doi: 10.1128/AAC.00731-18. Print 2018 Oct.


Efficacy of Intranasal Administration of the Recombinant Endolysin SAL200 in a Lethal Murine Staphylococcus aureus Pneumonia Model.

Bae JY, Jun KI, Kang CK, Song KH, Choe PG, Bang JH, Kim ES, Park SW, Kim HB, Kim NJ, Park WB, Oh MD.

Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e02009-18. doi: 10.1128/AAC.02009-18. Print 2019 Apr.


Antibacterial properties of a pre-formulated recombinant phage endolysin, SAL-1.

Jun SY, Jung GM, Yoon SJ, Oh MD, Choi YJ, Lee WJ, Kong JC, Seol JG, Kang SH.

Int J Antimicrob Agents. 2013 Feb;41(2):156-61. doi: 10.1016/j.ijantimicag.2012.10.011. Epub 2012 Dec 28.


Pharmacokinetics of the phage endolysin-based candidate drug SAL200 in monkeys and its appropriate intravenous dosing period.

Jun SY, Jung GM, Yoon SJ, Youm SY, Han HY, Lee JH, Kang SH.

Clin Exp Pharmacol Physiol. 2016 Oct;43(10):1013-6. doi: 10.1111/1440-1681.12613.


P-27/HP endolysin as antibacterial agent for antibiotic resistant Staphylococcus aureus of human infections.

Gupta R, Prasad Y.

Curr Microbiol. 2011 Jul;63(1):39-45. doi: 10.1007/s00284-011-9939-8. Epub 2011 Apr 27.


Synergistic Effect of Pleuromutilins with Other Antimicrobial Agents against Staphylococcus aureus In Vitro and in an Experimental Galleria mellonella Model.

Dong CL, Li LX, Cui ZH, Chen SW, Xiong YQ, Lu JQ, Liao XP, Gao Y, Sun J, Liu YH.

Front Pharmacol. 2017 Aug 22;8:553. doi: 10.3389/fphar.2017.00553. eCollection 2017.


Effects of single and combined use of bacteriophages and antibiotics to inactivate Escherichia coli.

Valério N, Oliveira C, Jesus V, Branco T, Pereira C, Moreirinha C, Almeida A.

Virus Res. 2017 Aug 15;240:8-17. doi: 10.1016/j.virusres.2017.07.015. Epub 2017 Jul 23.


Restoration of sensitivity of a diverse set of drug-resistant Staphylococcus clinical strains by bactericidal protein P128.

Nair S, Poonacha N, Desai S, Hiremath D, Tuppad D, Mohan T, Chikkamadaiah R, Durgaiah M, Kumar S, Channabasappa S, Vipra A, Sharma U.

J Med Microbiol. 2018 Mar;67(3):296-307. doi: 10.1099/jmm.0.000697. Epub 2018 Feb 6.


Pharmacokinetics and Tolerance of the Phage Endolysin-Based Candidate Drug SAL200 after a Single Intravenous Administration among Healthy Volunteers.

Jun SY, Jang IJ, Yoon S, Jang K, Yu KS, Cho JY, Seong MW, Jung GM, Yoon SJ, Kang SH.

Antimicrob Agents Chemother. 2017 May 24;61(6). pii: e02629-16. doi: 10.1128/AAC.02629-16. Print 2017 Jun.


Combination therapy with lysin CF-301 and antibiotic is superior to antibiotic alone for treating methicillin-resistant Staphylococcus aureus-induced murine bacteremia.

Schuch R, Lee HM, Schneider BC, Sauve KL, Law C, Khan BK, Rotolo JA, Horiuchi Y, Couto DE, Raz A, Fischetti VA, Huang DB, Nowinski RC, Wittekind M.

J Infect Dis. 2014 May 1;209(9):1469-78. doi: 10.1093/infdis/jit637. Epub 2013 Nov 28.


Chimeric phage lysins act synergistically with lysostaphin to kill mastitis-causing Staphylococcus aureus in murine mammary glands.

Schmelcher M, Powell AM, Becker SC, Camp MJ, Donovan DM.

Appl Environ Microbiol. 2012 Apr;78(7):2297-305. doi: 10.1128/AEM.07050-11. Epub 2012 Jan 27.


Lysis-deficient phages as novel therapeutic agents for controlling bacterial infection.

Paul VD, Sundarrajan S, Rajagopalan SS, Hariharan S, Kempashanaiah N, Padmanabhan S, Sriram B, Ramachandran J.

BMC Microbiol. 2011 Aug 31;11:195. doi: 10.1186/1471-2180-11-195.


Does Treatment Order Matter? Investigating the Ability of Bacteriophage to Augment Antibiotic Activity against Staphylococcus aureus Biofilms.

Kumaran D, Taha M, Yi Q, Ramirez-Arcos S, Diallo JS, Carli A, Abdelbary H.

Front Microbiol. 2018 Feb 5;9:127. doi: 10.3389/fmicb.2018.00127. eCollection 2018.


Wax moth larva (Galleria mellonella): an in vivo model for assessing the efficacy of antistaphylococcal agents.

Desbois AP, Coote PJ.

J Antimicrob Chemother. 2011 Aug;66(8):1785-90. doi: 10.1093/jac/dkr198. Epub 2011 May 28.


Synergistic effect of linezolid with fosfomycin against Staphylococcus aureus in vitro and in an experimental Galleria mellonella model.

Li L, Chen H, Liu Y, Xu S, Wu M, Liu Z, Qi C, Zhang G, Li J, Huang X.

J Microbiol Immunol Infect. 2018 Dec 31. pii: S1684-1182(18)30538-3. doi: 10.1016/j.jmii.2018.12.007. [Epub ahead of print]


Preclinical safety evaluation of intravenously administered SAL200 containing the recombinant phage endolysin SAL-1 as a pharmaceutical ingredient.

Jun SY, Jung GM, Yoon SJ, Choi YJ, Koh WS, Moon KS, Kang SH.

Antimicrob Agents Chemother. 2014;58(4):2084-8. doi: 10.1128/AAC.02232-13. Epub 2014 Jan 21.


Two Novel Bacteriophages Improve Survival in Galleria mellonella Infection and Mouse Acute Pneumonia Models Infected with Extensively Drug-Resistant Pseudomonas aeruginosa.

Jeon J, Yong D.

Appl Environ Microbiol. 2019 Apr 18;85(9). pii: e02900-18. doi: 10.1128/AEM.02900-18. Print 2019 May 1.


In vitro and in vivo activities of linezolid alone and combined with vancomycin and imipenem against Staphylococcus aureus with reduced susceptibility to glycopeptides.

Ribes S, Pachón-Ibáñez ME, Domínguez MA, Fernández R, Tubau F, Ariza J, Gudiol F, Cabellos C.

Eur J Clin Microbiol Infect Dis. 2010 Nov;29(11):1361-7. doi: 10.1007/s10096-010-1007-y. Epub 2010 Aug 1.


LysGH15, a novel bacteriophage lysin, protects a murine bacteremia model efficiently against lethal methicillin-resistant Staphylococcus aureus infection.

Gu J, Xu W, Lei L, Huang J, Feng X, Sun C, Du C, Zuo J, Li Y, Du T, Li L, Han W.

J Clin Microbiol. 2011 Jan;49(1):111-7. doi: 10.1128/JCM.01144-10. Epub 2010 Nov 3.


Efficacy of chimeric ectolysin P128 in drug-resistant Staphylococcus aureus bacteraemia in mice.

Channabasappa S, Chikkamadaiah R, Durgaiah M, Kumar S, Ramesh K, Sreekanthan A, Sriram B.

J Antimicrob Chemother. 2018 Dec 1;73(12):3398-3404. doi: 10.1093/jac/dky365.


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