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Items: 1 to 20 of 101

1.

Pancreatic deletion of the interleukin-1 receptor disrupts whole body glucose homeostasis and promotes islet β-cell de-differentiation.

Burke SJ, Batdorf HM, Burk DH, Martin TM, Mendoza T, Stadler K, Alami W, Karlstad MD, Robson MJ, Blakely RD, Mynatt RL, Collier JJ.

Mol Metab. 2018 Aug;14:95-107. doi: 10.1016/j.molmet.2018.06.003. Epub 2018 Jun 6.

2.

Pancreatic GLP-1 receptor activation is sufficient for incretin control of glucose metabolism in mice.

Lamont BJ, Li Y, Kwan E, Brown TJ, Gaisano H, Drucker DJ.

J Clin Invest. 2012 Jan;122(1):388-402. doi: 10.1172/JCI42497. Epub 2011 Dec 19.

3.
4.

Increased islet apoptosis in Pdx1+/- mice.

Johnson JD, Ahmed NT, Luciani DS, Han Z, Tran H, Fujita J, Misler S, Edlund H, Polonsky KS.

J Clin Invest. 2003 Apr;111(8):1147-60.

5.

MiR-338 controls BPA-triggered pancreatic islet insulin secretory dysfunction from compensation to decompensation by targeting Pdx-1.

Wei J, Ding D, Wang T, Liu Q, Lin Y.

FASEB J. 2017 Dec;31(12):5184-5195. doi: 10.1096/fj.201700282R. Epub 2017 Aug 3.

PMID:
28774890
6.

Islet-enriched gene expression and glucose-induced insulin secretion in human and mouse islets.

Dai C, Brissova M, Hang Y, Thompson C, Poffenberger G, Shostak A, Chen Z, Stein R, Powers AC.

Diabetologia. 2012 Mar;55(3):707-18. doi: 10.1007/s00125-011-2369-0. Epub 2011 Dec 14.

7.

Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha cell mass and impairs glucose homeostasis in mice.

Cantley J, Choudhury AI, Asare-Anane H, Selman C, Lingard S, Heffron H, Herrera P, Persaud SJ, Withers DJ.

Diabetologia. 2007 Jun;50(6):1248-56. Epub 2007 Mar 29.

PMID:
17393136
8.

PI3Kγ ablation does not promote diabetes in db/db mice, but improves insulin sensitivity and reduces pancreatic β-cell apoptosis.

Breasson L, Sardi C, Becattini B, Zani F, Solinas G.

FASEB J. 2018 Jan;32(1):319-329. doi: 10.1096/fj.201700372RR. Epub 2017 Sep 13.

PMID:
28904022
9.

Loss of fibroblast growth factor 21 action induces insulin resistance, pancreatic islet hyperplasia and dysfunction in mice.

So WY, Cheng Q, Xu A, Lam KS, Leung PS.

Cell Death Dis. 2015 Mar 26;6:e1707. doi: 10.1038/cddis.2015.80.

10.

Macrophage alterations in islets of obese mice linked to beta cell disruption in diabetes.

Chan JY, Lee K, Maxwell EL, Liang C, Laybutt DR.

Diabetologia. 2019 Mar 4. doi: 10.1007/s00125-019-4844-y. [Epub ahead of print]

PMID:
30830262
11.

Pancreatic Islet APJ Deletion Reduces Islet Density and Glucose Tolerance in Mice.

Han S, Englander EW, Gomez GA, Rastellini C, Quertermous T, Kundu RK, Greeley GH Jr.

Endocrinology. 2015 Jul;156(7):2451-60. doi: 10.1210/en.2014-1631. Epub 2015 May 12.

PMID:
25965959
12.

Heparan sulfate in pancreatic β-cells contributes to normal glucose homeostasis by regulating insulin secretion.

Matsuzawa T, Yoshikawa T, Iida T, Kárpáti A, Kitano H, Harada R, Nakamura T, Sugawara A, Yamaguchi Y, Yanai K.

Biochem Biophys Res Commun. 2018 May 15;499(3):688-695. doi: 10.1016/j.bbrc.2018.03.213. Epub 2018 Apr 3.

PMID:
29605295
13.

Amyloid formation disrupts the balance between interleukin-1β and interleukin-1 receptor antagonist in human islets.

Hui Q, Asadi A, Park YJ, Kieffer TJ, Ao Z, Warnock GL, Marzban L.

Mol Metab. 2017 May 31;6(8):833-844. doi: 10.1016/j.molmet.2017.05.016. eCollection 2017 Aug.

14.

Effects of biotin supplementation in the diet on insulin secretion, islet gene expression, glucose homeostasis and beta-cell proportion.

Lazo de la Vega-Monroy ML, Larrieta E, German MS, Baez-Saldana A, Fernandez-Mejia C.

J Nutr Biochem. 2013 Jan;24(1):169-77. doi: 10.1016/j.jnutbio.2012.03.020. Epub 2012 Jul 25.

PMID:
22841397
15.

Activin B regulates islet composition and islet mass but not whole body glucose homeostasis or insulin sensitivity.

Bonomi L, Brown M, Ungerleider N, Muse M, Matzuk MM, Schneyer A.

Am J Physiol Endocrinol Metab. 2012 Sep 1;303(5):E587-96. doi: 10.1152/ajpendo.00177.2012. Epub 2012 Jun 26.

16.

Circulating levels of IL-1B+IL-6 cause ER stress and dysfunction in islets from prediabetic male mice.

O'Neill CM, Lu C, Corbin KL, Sharma PR, Dula SB, Carter JD, Ramadan JW, Xin W, Lee JK, Nunemaker CS.

Endocrinology. 2013 Sep;154(9):3077-88. doi: 10.1210/en.2012-2138. Epub 2013 Jul 8.

17.

TLR2/6 and TLR4-activated macrophages contribute to islet inflammation and impair beta cell insulin gene expression via IL-1 and IL-6.

Nackiewicz D, Dan M, He W, Kim R, Salmi A, Rütti S, Westwell-Roper C, Cunningham A, Speck M, Schuster-Klein C, Guardiola B, Maedler K, Ehses JA.

Diabetologia. 2014 Aug;57(8):1645-54. doi: 10.1007/s00125-014-3249-1. Epub 2014 May 12.

PMID:
24816367
18.

SGLT2 deletion improves glucose homeostasis and preserves pancreatic beta-cell function.

Jurczak MJ, Lee HY, Birkenfeld AL, Jornayvaz FR, Frederick DW, Pongratz RL, Zhao X, Moeckel GW, Samuel VT, Whaley JM, Shulman GI, Kibbey RG.

Diabetes. 2011 Mar;60(3):890-8. doi: 10.2337/db10-1328.

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