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Haploid genetic screens identify genetic vulnerabilities to microtubule-targeting agents.

Gerhards NM, Blomen VA, Mutlu M, Nieuwenhuis J, Howald D, Guyader C, Jonkers J, Brummelkamp TR, Rottenberg S.

Mol Oncol. 2018 Jun;12(6):953-971. doi: 10.1002/1878-0261.12307. Epub 2018 May 1.


New tools for old drugs: Functional genetic screens to optimize current chemotherapy.

Gerhards NM, Rottenberg S.

Drug Resist Updat. 2018 Jan;36:30-46. doi: 10.1016/j.drup.2018.01.001. Epub 2018 Jan 12. Review.


Differential sensitivity of BRCA1-mutated HCC1937 human breast cancer cells to microtubule-interfering agents.

Tassone P, Blotta S, Palmieri C, Masciari S, Quaresima B, Montagna M, D'Andrea E, Eramo OP, Migale L, Costanzo F, Tagliaferri P, Venuta S.

Int J Oncol. 2005 May;26(5):1257-63.


The effects of vinflunine, vinorelbine, and vinblastine on centromere dynamics.

Okouneva T, Hill BT, Wilson L, Jordan MA.

Mol Cancer Ther. 2003 May;2(5):427-36.


The microtubule poison vinorelbine kills cells independently of mitotic arrest and targets cells lacking the APC tumour suppressor more effectively.

Klotz DM, Nelson SA, Kroboth K, Newton IP, Radulescu S, Ridgway RA, Sansom OJ, Appleton PL, Näthke IS.

J Cell Sci. 2012 Feb 15;125(Pt 4):887-95. doi: 10.1242/jcs.091843. Epub 2012 Mar 7.


Sensitivity of docetaxel-resistant MCF-7 breast cancer cells to microtubule-destabilizing agents including vinca alkaloids and colchicine-site binding agents.

Wang RC, Chen X, Parissenti AM, Joy AA, Tuszynski J, Brindley DN, Wang Z.

PLoS One. 2017 Aug 7;12(8):e0182400. doi: 10.1371/journal.pone.0182400. eCollection 2017.


Identification of Genes That Modulate Susceptibility to Formaldehyde and Imatinib by Functional Genomic Screening in Human Haploid KBM7 Cells.

Shen H, McHale CM, Haider SI, Jung C, Zhang S, Smith MT, Zhang L.

Toxicol Sci. 2016 May;151(1):10-22. doi: 10.1093/toxsci/kfw032. Epub 2016 Mar 22. Erratum in: Toxicol Sci. 2016 Nov;154(1):194.


Novel actions of the antitumor drugs vinflunine and vinorelbine on microtubules.

Ngan VK, Bellman K, Panda D, Hill BT, Jordan MA, Wilson L.

Cancer Res. 2000 Sep 15;60(18):5045-51.


Mitotic spindle checkpoint inactivation by trichostatin a defines a mechanism for increasing cancer cell killing by microtubule-disrupting agents.

Dowling M, Voong KR, Kim M, Keutmann MK, Harris E, Kao GD.

Cancer Biol Ther. 2005 Feb;4(2):197-206. Epub 2005 Feb 8.


Drugs that target dynamic microtubules: a new molecular perspective.

Stanton RA, Gernert KM, Nettles JH, Aneja R.

Med Res Rev. 2011 May;31(3):443-81. doi: 10.1002/med.20242. Epub 2011 Mar 4. Review.


6α-Acetoxyanopterine: A Novel Structure Class of Mitotic Inhibitor Disrupting Microtubule Dynamics in Prostate Cancer Cells.

Levrier C, Sadowski MC, Rockstroh A, Gabrielli B, Kavallaris M, Lehman M, Davis RA, Nelson CC.

Mol Cancer Ther. 2017 Jan;16(1):3-15. doi: 10.1158/1535-7163.MCT-16-0325. Epub 2016 Oct 19.


Vinorelbine in cancer therapy.

Capasso A.

Curr Drug Targets. 2012 Jul;13(8):1065-71. Review.


DT-13 synergistically enhanced vinorelbine-mediated mitotic arrest through inhibition of FOXM1-BICD2 axis in non-small-cell lung cancer cells.

Li H, Sun L, Li H, Lv X, Semukunzi H, Li R, Yu J, Yuan S, Lin S.

Cell Death Dis. 2017 May 25;8(5):e2810. doi: 10.1038/cddis.2017.218.


Potentiation of radiation therapy by vinorelbine (Navelbine) in non-small cell lung cancer.

Edelstein MP, Wolfe LA 3rd, Duch DS.

Semin Oncol. 1996 Apr;23(2 Suppl 5):41-7.


Mitotic drug targets and the development of novel anti-mitotic anticancer drugs.

Schmidt M, Bastians H.

Drug Resist Updat. 2007 Aug-Oct;10(4-5):162-81. Epub 2007 Jul 31. Review.


Vinorelbine's anti-tumor actions may depend on the mitotic apoptosis, autophagy and inflammation: hypotheses with implications for chemo-immunotherapy of advanced cancers and pediatric gliomas.

Altinoz MA, Ozpinar A, Alturfan EE, Elmaci I.

J Chemother. 2018 Jul;30(4):203-212. doi: 10.1080/1120009X.2018.1487149. Epub 2018 Jul 20. Review.


Post-slippage multinucleation renders cytotoxic variation in anti-mitotic drugs that target the microtubules or mitotic spindle.

Zhu Y, Zhou Y, Shi J.

Cell Cycle. 2014;13(11):1756-64. doi: 10.4161/cc.28672. Epub 2014 Apr 2.


The STARD9/Kif16a kinesin associates with mitotic microtubules and regulates spindle pole assembly.

Torres JZ, Summers MK, Peterson D, Brauer MJ, Lee J, Senese S, Gholkar AA, Lo YC, Lei X, Jung K, Anderson DC, Davis DP, Belmont L, Jackson PK.

Cell. 2011 Dec 9;147(6):1309-23. doi: 10.1016/j.cell.2011.11.020.

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