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Pluripotency transcription factors and Tet1/2 maintain Brd4-independent stem cell identity.

Finley LWS, Vardhana SA, Carey BW, Alonso-Curbelo D, Koche R, Chen Y, Wen D, King B, Radler MR, Rafii S, Lowe SW, Allis CD, Thompson CB.

Nat Cell Biol. 2018 May;20(5):565-574. doi: 10.1038/s41556-018-0086-3. Epub 2018 Apr 16.


Histone H4 acetylation and the epigenetic reader Brd4 are critical regulators of pluripotency in embryonic stem cells.

Gonzales-Cope M, Sidoli S, Bhanu NV, Won KJ, Garcia BA.

BMC Genomics. 2016 Feb 4;17:95. doi: 10.1186/s12864-016-2414-y.


Erk5 Is a Key Regulator of Naive-Primed Transition and Embryonic Stem Cell Identity.

Williams CA, Fernandez-Alonso R, Wang J, Toth R, Gray NS, Findlay GM.

Cell Rep. 2016 Aug 16;16(7):1820-8. doi: 10.1016/j.celrep.2016.07.033. Epub 2016 Aug 4.


BRD4 regulates Nanog expression in mouse embryonic stem cells and preimplantation embryos.

Liu W, Stein P, Cheng X, Yang W, Shao NY, Morrisey EE, Schultz RM, You J.

Cell Death Differ. 2014 Dec;21(12):1950-60. doi: 10.1038/cdd.2014.124. Epub 2014 Aug 22.


The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine.

Etchegaray JP, Chavez L, Huang Y, Ross KN, Choi J, Martinez-Pastor B, Walsh RM, Sommer CA, Lienhard M, Gladden A, Kugel S, Silberman DM, Ramaswamy S, Mostoslavsky G, Hochedlinger K, Goren A, Rao A, Mostoslavsky R.

Nat Cell Biol. 2015 May;17(5):545-57. doi: 10.1038/ncb3147. Epub 2015 Apr 27.


Nanog, Oct4 and Tet1 interplay in establishing pluripotency.

Olariu V, Lövkvist C, Sneppen K.

Sci Rep. 2016 May 5;6:25438. doi: 10.1038/srep25438.


Nanog requires BRD4 to maintain murine embryonic stem cell pluripotency and is suppressed by bromodomain inhibitor JQ1 together with Lefty1.

Horne GA, Stewart HJ, Dickson J, Knapp S, Ramsahoye B, Chevassut T.

Stem Cells Dev. 2015 Apr 1;24(7):879-91. doi: 10.1089/scd.2014.0302. Epub 2014 Dec 17.


Partial inhibition of differentiation associated with elevated protein levels of pluripotency factors in mouse embryonic stem cells expressing exogenous EGAM1N homeoprotein.

Sato S, Nakazawa M, Kihara Y, Kubo Y, Sato Y, Kikuchi T, Nonaka A, Sasaki A, Iwashita J, Murata J, Hosaka M, Kobayashi M.

J Biosci Bioeng. 2015 Nov;120(5):562-9. doi: 10.1016/j.jbiosc.2015.03.001. Epub 2015 Mar 26.


NANOG-dependent function of TET1 and TET2 in establishment of pluripotency.

Costa Y, Ding J, Theunissen TW, Faiola F, Hore TA, Shliaha PV, Fidalgo M, Saunders A, Lawrence M, Dietmann S, Das S, Levasseur DN, Li Z, Xu M, Reik W, Silva JC, Wang J.

Nature. 2013 Mar 21;495(7441):370-4. doi: 10.1038/nature11925. Epub 2013 Feb 10.


Expanding the Circuitry of Pluripotency by Selective Isolation of Chromatin-Associated Proteins.

Rafiee MR, Girardot C, Sigismondo G, Krijgsveld J.

Mol Cell. 2016 Nov 3;64(3):624-635. doi: 10.1016/j.molcel.2016.09.019. Epub 2016 Oct 20.


Adequate concentration of B cell leukemia/lymphoma 3 (Bcl3) is required for pluripotency and self-renewal of mouse embryonic stem cells via downregulation of Nanog transcription.

Kang S, Yun J, Kim DY, Jung SY, Kim YJ, Park JH, Ji ST, Jang WB, Ha J, Kim JH, Baek SH, Kwon SM.

BMB Rep. 2018 Feb;51(2):92-97.


KLF4 and PBX1 directly regulate NANOG expression in human embryonic stem cells.

Chan KK, Zhang J, Chia NY, Chan YS, Sim HS, Tan KS, Oh SK, Ng HH, Choo AB.

Stem Cells. 2009 Sep;27(9):2114-25. doi: 10.1002/stem.143.


Regulation of Nucleosome Architecture and Factor Binding Revealed by Nuclease Footprinting of the ESC Genome.

Hainer SJ, Fazzio TG.

Cell Rep. 2015 Oct 6;13(1):61-69. doi: 10.1016/j.celrep.2015.08.071. Epub 2015 Sep 24.


Acute depletion of Tet1-dependent 5-hydroxymethylcytosine levels impairs LIF/Stat3 signaling and results in loss of embryonic stem cell identity.

Freudenberg JM, Ghosh S, Lackford BL, Yellaboina S, Zheng X, Li R, Cuddapah S, Wade PA, Hu G, Jothi R.

Nucleic Acids Res. 2012 Apr;40(8):3364-77. doi: 10.1093/nar/gkr1253. Epub 2011 Dec 30.


Dynamic switching of active promoter and enhancer domains regulates Tet1 and Tet2 expression during cell state transitions between pluripotency and differentiation.

Sohni A, Bartoccetti M, Khoueiry R, Spans L, Vande Velde J, De Troyer L, Pulakanti K, Claessens F, Rao S, Koh KP.

Mol Cell Biol. 2015 Mar;35(6):1026-42. doi: 10.1128/MCB.01172-14. Epub 2015 Jan 12.


Zfp281 Coordinates Opposing Functions of Tet1 and Tet2 in Pluripotent States.

Fidalgo M, Huang X, Guallar D, Sanchez-Priego C, Valdes VJ, Saunders A, Ding J, Wu WS, Clavel C, Wang J.

Cell Stem Cell. 2016 Sep 1;19(3):355-69. doi: 10.1016/j.stem.2016.05.025. Epub 2016 Jun 23.


The BET family member BRD4 interacts with OCT4 and regulates pluripotency gene expression.

Wu T, Pinto HB, Kamikawa YF, Donohoe ME.

Stem Cell Reports. 2015 Mar 10;4(3):390-403. doi: 10.1016/j.stemcr.2015.01.012. Epub 2015 Feb 12.


Single-stranded DNA binding protein Ssbp3 induces differentiation of mouse embryonic stem cells into trophoblast-like cells.

Liu J, Luo X, Xu Y, Gu J, Tang F, Jin Y, Li H.

Stem Cell Res Ther. 2016 May 28;7(1):79. doi: 10.1186/s13287-016-0340-1.


Expression specificity and compensation effect of Ash2l-1/Ash2l-2 in mouse embryonic stem cells.

Xie J, Fan C, Zhang JL, Zhang SQ.

Yi Chuan. 2018 Mar 20;40(3):237-249. doi: 10.16288/j.yczz.17-284.


Roles of Klf5 Acetylation in the Self-Renewal and the Differentiation of Mouse Embryonic Stem Cells.

Zhao T, Liu C, Chen L.

PLoS One. 2015 Sep 15;10(9):e0138168. doi: 10.1371/journal.pone.0138168. eCollection 2015.

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