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Matriptase-2 deficiency protects from obesity by modulating iron homeostasis.

Folgueras AR, Freitas-Rodríguez S, Ramsay AJ, Garabaya C, Rodríguez F, Velasco G, López-Otín C.

Nat Commun. 2018 Apr 10;9(1):1350. doi: 10.1038/s41467-018-03853-1.


Retinal expression of the serine protease matriptase-2 (Tmprss6) and its role in retinal iron homeostasis.

Gnana-Prakasam JP, Baldowski RB, Ananth S, Martin PM, Smith SB, Ganapathy V.

Mol Vis. 2014 Apr 26;20:561-74. eCollection 2014.


Liver hemojuvelin protein levels in mice deficient in matriptase-2 (Tmprss6).

Krijt J, Fujikura Y, Ramsay AJ, Velasco G, Nečas E.

Blood Cells Mol Dis. 2011 Aug 15;47(2):133-7. doi: 10.1016/j.bcmd.2011.04.009. Epub 2011 May 25.


Mice that are fed a high-fat diet display increased hepcidin expression in adipose tissue.

Gotardo ÉM, dos Santos AN, Miyashiro RA, Gambero S, Rocha T, Ribeiro ML, Gambero A.

J Nutr Sci Vitaminol (Tokyo). 2013;59(5):454-61.


Limiting hepatic Bmp-Smad signaling by matriptase-2 is required for erythropoietin-mediated hepcidin suppression in mice.

Nai A, Rubio A, Campanella A, Gourbeyre O, Artuso I, Bordini J, Gineste A, Latour C, Besson-Fournier C, Lin HY, Coppin H, Roth MP, Camaschella C, Silvestri L, Meynard D.

Blood. 2016 May 12;127(19):2327-36. doi: 10.1182/blood-2015-11-681494. Epub 2016 Jan 11.


Matriptase-2 is essential for hepcidin repression during fetal life and postnatal development in mice to maintain iron homeostasis.

Willemetz A, Lenoir A, Deschemin JC, Lopez-Otin C, Ramsay AJ, Vaulont S, Nicolas G.

Blood. 2014 Jul 17;124(3):441-4. doi: 10.1182/blood-2014-01-551150. Epub 2014 Jun 5.


Matriptase-2 suppresses hepcidin expression by cleaving multiple components of the hepcidin induction pathway.

Wahedi M, Wortham AM, Kleven MD, Zhao N, Jue S, Enns CA, Zhang AS.

J Biol Chem. 2017 Nov 3;292(44):18354-18371. doi: 10.1074/jbc.M117.801795. Epub 2017 Sep 18.


Bmp6 expression in murine liver non parenchymal cells: a mechanism to control their high iron exporter activity and protect hepatocytes from iron overload?

Rausa M, Pagani A, Nai A, Campanella A, Gilberti ME, Apostoli P, Camaschella C, Silvestri L.

PLoS One. 2015 Apr 10;10(4):e0122696. doi: 10.1371/journal.pone.0122696. eCollection 2015.


Regulation of type II transmembrane serine proteinase TMPRSS6 by hypoxia-inducible factors: new link between hypoxia signaling and iron homeostasis.

Lakhal S, Schödel J, Townsend AR, Pugh CW, Ratcliffe PJ, Mole DR.

J Biol Chem. 2011 Feb 11;286(6):4090-7. doi: 10.1074/jbc.M110.173096. Epub 2010 Oct 21.


Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis.

Finberg KE, Whittlesey RL, Fleming MD, Andrews NC.

Blood. 2010 May 6;115(18):3817-26. doi: 10.1182/blood-2009-05-224808. Epub 2010 Mar 3.


Role of matriptase-2 (TMPRSS6) in iron metabolism.

Lee P.

Acta Haematol. 2009;122(2-3):87-96. doi: 10.1159/000243792. Epub 2009 Nov 10. Review.


Effect of erythropoietin administration on proteins participating in iron homeostasis in Tmprss6-mutated mask mice.

Frýdlová J, Rychtarčíková Z, Gurieva I, Vokurka M, Truksa J, Krijt J.

PLoS One. 2017 Oct 26;12(10):e0186844. doi: 10.1371/journal.pone.0186844. eCollection 2017.


Regulation of TMPRSS6 by BMP6 and iron in human cells and mice.

Meynard D, Vaja V, Sun CC, Corradini E, Chen S, López-Otín C, Grgurevic L, Hong CC, Stirnberg M, Gütschow M, Vukicevic S, Babitt JL, Lin HY.

Blood. 2011 Jul 21;118(3):747-56. doi: 10.1182/blood-2011-04-348698. Epub 2011 May 26.


The erythroid function of transferrin receptor 2 revealed by Tmprss6 inactivation in different models of transferrin receptor 2 knockout mice.

Nai A, Pellegrino RM, Rausa M, Pagani A, Boero M, Silvestri L, Saglio G, Roetto A, Camaschella C.

Haematologica. 2014 Jun;99(6):1016-21. doi: 10.3324/haematol.2013.103143. Epub 2014 Mar 21.


Severe microcytic anemia but increased erythropoiesis in mice lacking Hfe or Tfr2 and Tmprss6.

Lee P, Hsu MH, Welser-Alves J, Peng H.

Blood Cells Mol Dis. 2012 Mar 15;48(3):173-8. doi: 10.1016/j.bcmd.2011.12.005. Epub 2012 Jan 14.


An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe(-/-) mice and ameliorates anemia and iron overload in murine β-thalassemia intermedia.

Schmidt PJ, Toudjarska I, Sendamarai AK, Racie T, Milstein S, Bettencourt BR, Hettinger J, Bumcrot D, Fleming MD.

Blood. 2013 Feb 14;121(7):1200-8. doi: 10.1182/blood-2012-09-453977. Epub 2012 Dec 6.


Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis.

Folgueras AR, de Lara FM, Pendás AM, Garabaya C, Rodríguez F, Astudillo A, Bernal T, Cabanillas R, López-Otín C, Velasco G.

Blood. 2008 Sep 15;112(6):2539-45. doi: 10.1182/blood-2008-04-149773. Epub 2008 Jun 3.


Essential role of endocytosis of the type II transmembrane serine protease TMPRSS6 in regulating its functionality.

Béliveau F, Brulé C, Désilets A, Zimmerman B, Laporte SA, Lavoie CL, Leduc R.

J Biol Chem. 2011 Aug 19;286(33):29035-43. doi: 10.1074/jbc.M111.223461. Epub 2011 Jul 1.


Tmprss6 is a genetic modifier of the Hfe-hemochromatosis phenotype in mice.

Finberg KE, Whittlesey RL, Andrews NC.

Blood. 2011 Apr 28;117(17):4590-9. doi: 10.1182/blood-2010-10-315507. Epub 2011 Feb 25.


Iron-deficiency anemia from matriptase-2 inactivation is dependent on the presence of functional Bmp6.

Lenoir A, Deschemin JC, Kautz L, Ramsay AJ, Roth MP, Lopez-Otin C, Vaulont S, Nicolas G.

Blood. 2011 Jan 13;117(2):647-50. doi: 10.1182/blood-2010-07-295147. Epub 2010 Oct 12.

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