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Nitrate, the oral microbiome, and cardiovascular health: a systematic literature review of human and animal studies.

Blekkenhorst LC, Bondonno NP, Liu AH, Ward NC, Prince RL, Lewis JR, Devine A, Croft KD, Hodgson JM, Bondonno CP.

Am J Clin Nutr. 2018 Apr 1;107(4):504-522. doi: 10.1093/ajcn/nqx046.


Dietary Nitrate, Nitric Oxide, and Cardiovascular Health.

Bondonno CP, Croft KD, Hodgson JM.

Crit Rev Food Sci Nutr. 2016 Sep 9;56(12):2036-52. doi: 10.1080/10408398.2013.811212. Review.


The role of inorganic nitrate and nitrite in cardiovascular disease risk factors: a systematic review and meta-analysis of human evidence.

Jackson JK, Patterson AJ, MacDonald-Wicks LK, Oldmeadow C, McEvoy MA.

Nutr Rev. 2018 May 1;76(5):348-371. doi: 10.1093/nutrit/nuy005.


Vegetable-derived bioactive nitrate and cardiovascular health.

Bondonno CP, Blekkenhorst LC, Liu AH, Bondonno NP, Ward NC, Croft KD, Hodgson JM.

Mol Aspects Med. 2018 Jun;61:83-91. doi: 10.1016/j.mam.2017.08.001. Epub 2017 Sep 7. Review.


Frequency of Tongue Cleaning Impacts the Human Tongue Microbiome Composition and Enterosalivary Circulation of Nitrate.

Tribble GD, Angelov N, Weltman R, Wang BY, Eswaran SV, Gay IC, Parthasarathy K, Dao DV, Richardson KN, Ismail NM, Sharina IG, Hyde ER, Ajami NJ, Petrosino JF, Bryan NS.

Front Cell Infect Microbiol. 2019 Mar 1;9:39. doi: 10.3389/fcimb.2019.00039. eCollection 2019.


Clinical evidence demonstrating the utility of inorganic nitrate in cardiovascular health.

Kapil V, Weitzberg E, Lundberg JO, Ahluwalia A.

Nitric Oxide. 2014 Apr 30;38:45-57. doi: 10.1016/j.niox.2014.03.162. Epub 2014 Mar 18. Review.


Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health.

Koch CD, Gladwin MT, Freeman BA, Lundberg JO, Weitzberg E, Morris A.

Free Radic Biol Med. 2017 Apr;105:48-67. doi: 10.1016/j.freeradbiomed.2016.12.015. Epub 2016 Dec 16. Review.


Vascular effects of dietary nitrate (as found in green leafy vegetables and beetroot) via the nitrate-nitrite-nitric oxide pathway.

Lidder S, Webb AJ.

Br J Clin Pharmacol. 2013 Mar;75(3):677-96. doi: 10.1111/j.1365-2125.2012.04420.x.


The effects of dietary nitrate on blood pressure and endothelial function: a review of human intervention studies.

Hobbs DA, George TW, Lovegrove JA.

Nutr Res Rev. 2013 Dec;26(2):210-22. doi: 10.1017/S0954422413000188. Epub 2013 Oct 18. Review.


Cross-talk Between Nitrate-Nitrite-NO and NO Synthase Pathways in Control of Vascular NO Homeostasis.

Carlström M, Liu M, Yang T, Zollbrecht C, Huang L, Peleli M, Borniquel S, Kishikawa H, Hezel M, Persson AE, Weitzberg E, Lundberg JO.

Antioxid Redox Signal. 2015 Aug 1;23(4):295-306. doi: 10.1089/ars.2013.5481. Epub 2014 Feb 6.


Low-Dose Aspirin for the Prevention of Morbidity and Mortality From Preeclampsia: A Systematic Evidence Review for the U.S. Preventive Services Task Force [Internet].

Henderson JT, Whitlock EP, O'Conner E, Senger CA, Thompson JH, Rowland MG.

Rockville (MD): Agency for Healthcare Research and Quality (US); 2014 Apr.


Therapeutic effects of inorganic nitrate and nitrite in cardiovascular and metabolic diseases.

Omar SA, Webb AJ, Lundberg JO, Weitzberg E.

J Intern Med. 2016 Apr;279(4):315-36. doi: 10.1111/joim.12441. Epub 2015 Nov 2. Review.


It is rocket science - why dietary nitrate is hard to 'beet'! Part I: twists and turns in the realization of the nitrate-nitrite-NO pathway.

Khatri J, Mills CE, Maskell P, Odongerel C, Webb AJ.

Br J Clin Pharmacol. 2017 Jan;83(1):129-139. doi: 10.1111/bcp.12913. Epub 2016 May 6. Review.


Mechanisms underlying blood pressure reduction by dietary inorganic nitrate.

Carlström M, Lundberg JO, Weitzberg E.

Acta Physiol (Oxf). 2018 Sep;224(1):e13080. doi: 10.1111/apha.13080. Epub 2018 May 16. Review.


Characterization of the rat oral microbiome and the effects of dietary nitrate.

Hyde ER, Luk B, Cron S, Kusic L, McCue T, Bauch T, Kaplan H, Tribble G, Petrosino JF, Bryan NS.

Free Radic Biol Med. 2014 Dec;77:249-57. doi: 10.1016/j.freeradbiomed.2014.09.017. Epub 2014 Oct 12.


Short-term effects of nitrate-rich green leafy vegetables on blood pressure and arterial stiffness in individuals with high-normal blood pressure.

Bondonno CP, Liu AH, Croft KD, Ward NC, Yang X, Considine MJ, Puddey IB, Woodman RJ, Hodgson JM.

Free Radic Biol Med. 2014 Dec;77:353-62. doi: 10.1016/j.freeradbiomed.2014.09.021. Epub 2014 Sep 28.


It is rocket science - why dietary nitrate is hard to 'beet'! Part II: further mechanisms and therapeutic potential of the nitrate-nitrite-NO pathway.

Mills CE, Khatri J, Maskell P, Odongerel C, Webb AJ.

Br J Clin Pharmacol. 2017 Jan;83(1):140-151. doi: 10.1111/bcp.12918. Epub 2016 May 6.


Effect of the amount and type of dietary fat on cardiometabolic risk factors and risk of developing type 2 diabetes, cardiovascular diseases, and cancer: a systematic review.

Schwab U, Lauritzen L, Tholstrup T, Haldorssoni T, Riserus U, Uusitupa M, Becker W.

Food Nutr Res. 2014 Jul 10;58. doi: 10.3402/fnr.v58.25145. eCollection 2014. Review.


Enhanced XOR activity in eNOS-deficient mice: Effects on the nitrate-nitrite-NO pathway and ROS homeostasis.

Peleli M, Zollbrecht C, Montenegro MF, Hezel M, Zhong J, Persson EG, Holmdahl R, Weitzberg E, Lundberg JO, Carlström M.

Free Radic Biol Med. 2016 Oct;99:472-484. doi: 10.1016/j.freeradbiomed.2016.09.004. Epub 2016 Sep 5.


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