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Validation of a Host Response Assay, SeptiCyte LAB, for Discriminating Sepsis from Systemic Inflammatory Response Syndrome in the ICU.

Miller RR 3rd, Lopansri BK, Burke JP, Levy M, Opal S, Rothman RE, D'Alessio FR, Sidhaye VK, Aggarwal NR, Balk R, Greenberg JA, Yoder M, Patel G, Gilbert E, Afshar M, Parada JP, Martin GS, Esper AM, Kempker JA, Narasimhan M, Tsegaye A, Hahn S, Mayo P, van der Poll T, Schultz MJ, Scicluna BP, Klein Klouwenberg P, Rapisarda A, Seldon TA, McHugh LC, Yager TD, Cermelli S, Sampson D, Rothwell V, Newman R, Bhide S, Fox BA, Kirk JT, Navalkar K, Davis RF, Brandon RA, Brandon RB.

Am J Respir Crit Care Med. 2018 Oct 1;198(7):903-913. doi: 10.1164/rccm.201712-2472OC.


A Molecular Host Response Assay to Discriminate Between Sepsis and Infection-Negative Systemic Inflammation in Critically Ill Patients: Discovery and Validation in Independent Cohorts.

McHugh L, Seldon TA, Brandon RA, Kirk JT, Rapisarda A, Sutherland AJ, Presneill JJ, Venter DJ, Lipman J, Thomas MR, Klein Klouwenberg PM, van Vught L, Scicluna B, Bonten M, Cremer OL, Schultz MJ, van der Poll T, Yager TD, Brandon RB.

PLoS Med. 2015 Dec 8;12(12):e1001916. doi: 10.1371/journal.pmed.1001916. eCollection 2015 Dec.


Diagnostic Accuracy of a Host Gene Expression Signature That Discriminates Clinical Severe Sepsis Syndrome and Infection-Negative Systemic Inflammation Among Critically Ill Children.

Zimmerman JJ, Sullivan E, Yager TD, Cheng C, Permut L, Cermelli S, McHugh L, Sampson D, Seldon T, Brandon RB, Brandon RA.

Crit Care Med. 2017 Apr;45(4):e418-e425. doi: 10.1097/CCM.0000000000002100.


Benchmarking Sepsis Gene Expression Diagnostics Using Public Data.

Sweeney TE, Khatri P.

Crit Care Med. 2017 Jan;45(1):1-10.


Validation of a Novel Molecular Host Response Assay to Diagnose Infection in Hospitalized Patients Admitted to the ICU With Acute Respiratory Failure.

Koster-Brouwer ME, Verboom DM, Scicluna BP, van de Groep K, Frencken JF, Janssen D, Schuurman R, Schultz MJ, van der Poll T, Bonten MJM, Cremer OL; MARS Consortium.

Crit Care Med. 2018 Mar;46(3):368-374. doi: 10.1097/CCM.0000000000002735.


Likelihood of infection in patients with presumed sepsis at the time of intensive care unit admission: a cohort study.

Klein Klouwenberg PM, Cremer OL, van Vught LA, Ong DS, Frencken JF, Schultz MJ, Bonten MJ, van der Poll T.

Crit Care. 2015 Sep 7;19:319. doi: 10.1186/s13054-015-1035-1.


[Value of interleukin-27 as a diagnostic biomarker of sepsis in critically ill adults].

Fu J, Wang Y, Zeng P, Niu S.

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2015 Jun;27(6):460-4. doi: 10.3760/cma.j.issn.2095-4352.2015.06.009. Chinese.


[Diagnostic value of serum procalcitonin for infection in the immunocompromised critically ill patients with suspected infection].

Yu X, Ma X, Ai Y.

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2015 Jun;27(6):477-83. doi: 10.3760/cma.j.issn.2095-4352.2015.06.012. Chinese.


Next-generation sequencing diagnostics of bacteremia in sepsis (Next GeneSiS-Trial): Study protocol of a prospective, observational, noninterventional, multicenter, clinical trial.

Brenner T, Decker SO, Grumaz S, Stevens P, Bruckner T, Schmoch T, Pletz MW, Bracht H, Hofer S, Marx G, Weigand MA, Sohn K; TIFOnet Critical Care Trials Group.

Medicine (Baltimore). 2018 Feb;97(6):e9868. doi: 10.1097/MD.0000000000009868.


[The prognostic value of serum procalcitonin on severity of illness in non-sepsis critically ill patients].

Ma J, Wang S, Chen D, Duan J, Li C, Li G.

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2016 Aug;28(8):688-93. doi: 10.3760/cma.j.issn.2095-4352.2016.08.004. Chinese.


Similar Metabolic, Innate Immunity, and Adipokine Profiles in Adult and Pediatric Sepsis Versus Systemic Inflammatory Response Syndrome-A Pilot Study.

Tavladaki T, Spanaki AM, Dimitriou H, Kondili E, Choulaki C, Georgopoulos D, Briassoulis G.

Pediatr Crit Care Med. 2017 Nov;18(11):e494-e505. doi: 10.1097/PCC.0000000000001300.


The diagnostic ability of procalcitonin and interleukin-6 to differentiate infectious from noninfectious systemic inflammatory response syndrome and to predict mortality.

Mat-Nor MB, Md Ralib A, Abdulah NZ, Pickering JW.

J Crit Care. 2016 Jun;33:245-51. doi: 10.1016/j.jcrc.2016.01.002. Epub 2016 Jan 7.


Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: a systematic review and meta-analysis.

Uzzan B, Cohen R, Nicolas P, Cucherat M, Perret GY.

Crit Care Med. 2006 Jul;34(7):1996-2003. Review.


Procalcitonin as a rapid diagnostic biomarker to differentiate between culture-negative bacterial sepsis and systemic inflammatory response syndrome: a prospective, observational, cohort study.

Anand D, Das S, Bhargava S, Srivastava LM, Garg A, Tyagi N, Taneja S, Ray S.

J Crit Care. 2015 Feb;30(1):218.e7-12. doi: 10.1016/j.jcrc.2014.08.017. Epub 2014 Sep 6.


Quick Sequential Organ Failure Assessment and Systemic Inflammatory Response Syndrome Criteria as Predictors of Critical Care Intervention Among Patients With Suspected Infection.

Moskowitz A, Patel PV, Grossestreuer AV, Chase M, Shapiro NI, Berg K, Cocchi MN, Holmberg MJ, Donnino MW; Center for Resuscitation Science.

Crit Care Med. 2017 Nov;45(11):1813-1819. doi: 10.1097/CCM.0000000000002622.


Decrease in Histidine-Rich Glycoprotein as a Novel Biomarker to Predict Sepsis Among Systemic Inflammatory Response Syndrome.

Kuroda K, Wake H, Mori S, Hinotsu S, Nishibori M, Morimatsu H.

Crit Care Med. 2018 Apr;46(4):570-576. doi: 10.1097/CCM.0000000000002947.


The utility of proadrenomedullin and procalcitonin in comparison to C-reactive protein as predictors of sepsis and bloodstream infections in critically ill patients with cancer*.

Debiane L, Hachem RY, Al Wohoush I, Shomali W, Bahu RR, Jiang Y, Chaftari AM, Jabbour J, Al Shuaibi M, Hanania A, Pravinkumar SE, Schuetz P, Raad I.

Crit Care Med. 2014 Dec;42(12):2500-7. doi: 10.1097/CCM.0000000000000526.


Lipopolysaccharide binding protein in a surgical intensive care unit: a marker of sepsis?

Sakr Y, Burgett U, Nacul FE, Reinhart K, Brunkhorst F.

Crit Care Med. 2008 Jul;36(7):2014-22. doi: 10.1097/CCM.0b013e31817b86e3.


A Two-Biomarker Model Predicts Mortality in the Critically Ill with Sepsis.

Mikacenic C, Price BL, Harju-Baker S, O'Mahony DS, Robinson-Cohen C, Radella F, Hahn WO, Katz R, Christiani DC, Himmelfarb J, Liles WC, Wurfel MM.

Am J Respir Crit Care Med. 2017 Oct 15;196(8):1004-1011. doi: 10.1164/rccm.201611-2307OC.

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