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Items: 1 to 20 of 101

1.

Regenerative proliferation of differentiated cells by mTORC1-dependent paligenosis.

Willet SG, Lewis MA, Miao ZF, Liu D, Radyk MD, Cunningham RL, Burclaff J, Sibbel G, Lo HG, Blanc V, Davidson NO, Wang ZN, Mills JC.

EMBO J. 2018 Apr 3;37(7). pii: e98311. doi: 10.15252/embj.201798311. Epub 2018 Feb 21.

2.

Maturity and age influence chief cell ability to transdifferentiate into metaplasia.

Weis VG, Petersen CP, Weis JA, Meyer AR, Choi E, Mills JC, Goldenring JR.

Am J Physiol Gastrointest Liver Physiol. 2017 Jan 1;312(1):G67-G76. doi: 10.1152/ajpgi.00326.2016. Epub 2016 Nov 23.

3.

Reserve stem cells: Differentiated cells reprogram to fuel repair, metaplasia, and neoplasia in the adult gastrointestinal tract.

Mills JC, Sansom OJ.

Sci Signal. 2015 Jul 14;8(385):re8. doi: 10.1126/scisignal.aaa7540. Review.

4.

Metaplastic Cells in the Stomach Arise, Independently of Stem Cells, via Dedifferentiation or Transdifferentiation of Chief Cells.

Radyk MD, Burclaff J, Willet SG, Mills JC.

Gastroenterology. 2018 Mar;154(4):839-843.e2. doi: 10.1053/j.gastro.2017.11.278. Epub 2017 Dec 14.

5.

NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription and Acinar-Ductal Transdifferentiation in the Pancreas.

Chen NM, Singh G, Koenig A, Liou GY, Storz P, Zhang JS, Regul L, Nagarajan S, K├╝hnemuth B, Johnsen SA, Hebrok M, Siveke J, Billadeau DD, Ellenrieder V, Hessmann E.

Gastroenterology. 2015 May;148(5):1024-1034.e9. doi: 10.1053/j.gastro.2015.01.033. Epub 2015 Jan 23.

6.

Targeted Apoptosis of Parietal Cells Is Insufficient to Induce Metaplasia in Stomach.

Burclaff J, Osaki LH, Liu D, Goldenring JR, Mills JC.

Gastroenterology. 2017 Mar;152(4):762-766.e7. doi: 10.1053/j.gastro.2016.12.001. Epub 2016 Dec 5.

7.

Are Gastric and Esophageal Metaplasia Relatives? The Case for Barrett's Stemming from SPEM.

Jin RU, Mills JC.

Dig Dis Sci. 2018 Aug;63(8):2028-2041. doi: 10.1007/s10620-018-5150-0. Review.

PMID:
29948563
8.

p21(WAF1) (/Cip1) limits senescence and acinar-to-ductal metaplasia formation during pancreatitis.

Grabliauskaite K, Hehl AB, Seleznik GM, Saponara E, Schlesinger K, Zuellig RA, Dittmann A, Bain M, Reding T, Sonda S, Graf R.

J Pathol. 2015 Feb;235(3):502-14. doi: 10.1002/path.4440. Epub 2014 Nov 6.

9.

Mature chief cells are cryptic progenitors for metaplasia in the stomach.

Nam KT, Lee HJ, Sousa JF, Weis VG, O'Neal RL, Finke PE, Romero-Gallo J, Shi G, Mills JC, Peek RM Jr, Konieczny SF, Goldenring JR.

Gastroenterology. 2010 Dec;139(6):2028-2037.e9. doi: 10.1053/j.gastro.2010.09.005. Epub 2010 Sep 18.

10.

The origin of pre-neoplastic metaplasia in the stomach: chief cells emerge from the Mist.

Goldenring JR, Nam KT, Mills JC.

Exp Cell Res. 2011 Nov 15;317(19):2759-64. doi: 10.1016/j.yexcr.2011.08.017. Epub 2011 Aug 31. Review.

11.

Serotonin promotes acinar dedifferentiation following pancreatitis-induced regeneration in the adult pancreas.

Saponara E, Grabliauskaite K, Bombardo M, Buzzi R, Silva AB, Malagola E, Tian Y, Hehl AB, Schraner EM, Seleznik GM, Zabel A, Reding T, Sonda S, Graf R.

J Pathol. 2015 Dec;237(4):495-507. doi: 10.1002/path.4595. Epub 2015 Sep 10.

12.

Calorie Restriction Governs Intestinal Epithelial Regeneration through Cell-Autonomous Regulation of mTORC1 in Reserve Stem Cells.

Yousefi M, Nakauka-Ddamba A, Berry CT, Li N, Schoenberger J, Simeonov KP, Cedeno RJ, Yu Z, Lengner CJ.

Stem Cell Reports. 2018 Mar 13;10(3):703-711. doi: 10.1016/j.stemcr.2018.01.026. Epub 2018 Mar 1.

13.

Expression of Activated Ras in Gastric Chief Cells of Mice Leads to the Full Spectrum of Metaplastic Lineage Transitions.

Choi E, Hendley AM, Bailey JM, Leach SD, Goldenring JR.

Gastroenterology. 2016 Apr;150(4):918-30.e13. doi: 10.1053/j.gastro.2015.11.049. Epub 2015 Dec 8.

14.

A molecular signature of gastric metaplasia arising in response to acute parietal cell loss.

Nozaki K, Ogawa M, Williams JA, Lafleur BJ, Ng V, Drapkin RI, Mills JC, Konieczny SF, Nomura S, Goldenring JR.

Gastroenterology. 2008 Feb;134(2):511-22. doi: 10.1053/j.gastro.2007.11.058. Epub 2007 Dec 4.

15.

In vivo lineage tracing defines the role of acinar-to-ductal transdifferentiation in inflammatory ductal metaplasia.

Strobel O, Dor Y, Alsina J, Stirman A, Lauwers G, Trainor A, Castillo CF, Warshaw AL, Thayer SP.

Gastroenterology. 2007 Dec;133(6):1999-2009. Epub 2007 Sep 14.

16.

Numb regulates acinar cell dedifferentiation and survival during pancreatic damage and acinar-to-ductal metaplasia.

Greer RL, Staley BK, Liou A, Hebrok M.

Gastroenterology. 2013 Nov;145(5):1088-1097.e8. doi: 10.1053/j.gastro.2013.07.027. Epub 2013 Jul 25.

17.

mTORC1 activates SREBP-2 by suppressing cholesterol trafficking to lysosomes in mammalian cells.

Eid W, Dauner K, Courtney KC, Gagnon A, Parks RJ, Sorisky A, Zha X.

Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):7999-8004. doi: 10.1073/pnas.1705304114. Epub 2017 Jul 10.

18.

Mononuclear cells from dedifferentiation of mouse myotubes display remarkable regenerative capability.

Yang Z, Liu Q, Mannix RJ, Xu X, Li H, Ma Z, Ingber DE, Allen PD, Wang Y.

Stem Cells. 2014 Sep;32(9):2492-501. doi: 10.1002/stem.1742.

19.

The transcription factor MIST1 is a novel human gastric chief cell marker whose expression is lost in metaplasia, dysplasia, and carcinoma.

Lennerz JK, Kim SH, Oates EL, Huh WJ, Doherty JM, Tian X, Bredemeyer AJ, Goldenring JR, Lauwers GY, Shin YK, Mills JC.

Am J Pathol. 2010 Sep;177(3):1514-33. doi: 10.2353/ajpath.2010.100328. Epub 2010 Aug 13.

20.

Plasticity of differentiated cells in wound repair and tumorigenesis, part I: stomach and pancreas.

Burclaff J, Mills JC.

Dis Model Mech. 2018 Jul 23;11(7). pii: dmm033373. doi: 10.1242/dmm.033373. Review.

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