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Items: 1 to 20 of 102

1.

C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction.

Lautenschläger J, Stephens AD, Fusco G, Ströhl F, Curry N, Zacharopoulou M, Michel CH, Laine R, Nespovitaya N, Fantham M, Pinotsi D, Zago W, Fraser P, Tandon A, St George-Hyslop P, Rees E, Phillips JJ, De Simone A, Kaminski CF, Schierle GSK.

Nat Commun. 2018 Feb 19;9(1):712. doi: 10.1038/s41467-018-03111-4.

2.

Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein.

Cabin DE, Shimazu K, Murphy D, Cole NB, Gottschalk W, McIlwain KL, Orrison B, Chen A, Ellis CE, Paylor R, Lu B, Nussbaum RL.

J Neurosci. 2002 Oct 15;22(20):8797-807.

3.

Alpha-synuclein is localized in a subpopulation of rat brain synaptic vesicles.

Lee SJ, Jeon H, Kandror KV.

Acta Neurobiol Exp (Wars). 2008;68(4):509-15.

4.

Acute increase of α-synuclein inhibits synaptic vesicle recycling evoked during intense stimulation.

Busch DJ, Oliphint PA, Walsh RB, Banks SM, Woods WS, George JM, Morgan JR.

Mol Biol Cell. 2014 Dec 1;25(24):3926-41. doi: 10.1091/mbc.E14-02-0708. Epub 2014 Oct 1.

5.

Structure and dynamics of the extended-helix state of alpha-synuclein: Intrinsic lability of the linker region.

Sung YH, Eliezer D.

Protein Sci. 2018 Jul;27(7):1314-1324. doi: 10.1002/pro.3426.

PMID:
29663556
6.

Neural activity controls the synaptic accumulation of alpha-synuclein.

Fortin DL, Nemani VM, Voglmaier SM, Anthony MD, Ryan TA, Edwards RH.

J Neurosci. 2005 Nov 23;25(47):10913-21.

7.

Contrasting effects of α-synuclein and γ-synuclein on the phenotype of cysteine string protein α (CSPα) null mutant mice suggest distinct function of these proteins in neuronal synapses.

Ninkina N, Peters OM, Connor-Robson N, Lytkina O, Sharfeddin E, Buchman VL.

J Biol Chem. 2012 Dec 28;287(53):44471-7. doi: 10.1074/jbc.M112.422402. Epub 2012 Nov 5.

8.

α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation.

Burré J, Sharma M, Südhof TC.

Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):E4274-83. doi: 10.1073/pnas.1416598111. Epub 2014 Sep 22.

9.

Binding of alpha-synuclein affects the lipid packing in bilayers of small vesicles.

Kamp F, Beyer K.

J Biol Chem. 2006 Apr 7;281(14):9251-9. Epub 2006 Feb 1.

10.

19F NMR studies of α-synuclein-membrane interactions.

Wang GF, Li C, Pielak GJ.

Protein Sci. 2010 Sep;19(9):1686-91. doi: 10.1002/pro.449.

11.

Multiple tight phospholipid-binding modes of alpha-synuclein revealed by solution NMR spectroscopy.

Bodner CR, Dobson CM, Bax A.

J Mol Biol. 2009 Jul 24;390(4):775-90. doi: 10.1016/j.jmb.2009.05.066. Epub 2009 May 27.

12.

Structural Ensembles of Membrane-bound α-Synuclein Reveal the Molecular Determinants of Synaptic Vesicle Affinity.

Fusco G, De Simone A, Arosio P, Vendruscolo M, Veglia G, Dobson CM.

Sci Rep. 2016 Jun 8;6:27125. doi: 10.1038/srep27125.

13.

Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2.

Diao J, Burré J, Vivona S, Cipriano DJ, Sharma M, Kyoung M, Südhof TC, Brunger AT.

Elife. 2013 Apr 30;2:e00592. doi: 10.7554/eLife.00592.

14.

Small molecule-mediated stabilization of vesicle-associated helical α-synuclein inhibits pathogenic misfolding and aggregation.

Fonseca-Ornelas L, Eisbach SE, Paulat M, Giller K, Fernández CO, Outeiro TF, Becker S, Zweckstetter M.

Nat Commun. 2014 Dec 19;5:5857. doi: 10.1038/ncomms6857.

PMID:
25524885
15.

Synphilin-1 is developmentally localized to synaptic terminals, and its association with synaptic vesicles is modulated by alpha-synuclein.

Ribeiro CS, Carneiro K, Ross CA, Menezes JR, Engelender S.

J Biol Chem. 2002 Jun 28;277(26):23927-33. Epub 2002 Apr 15. Erratum in: J Biol Chem 2002 Sep 13;277(37):34651-4.

16.

Effect of pseudorepeat rearrangement on alpha-synuclein misfolding, vesicle binding, and micelle binding.

Rao JN, Kim YE, Park LS, Ulmer TS.

J Mol Biol. 2009 Jul 17;390(3):516-29. doi: 10.1016/j.jmb.2009.05.058. Epub 2009 May 27.

17.

Lipid vesicles affect the aggregation of 4-hydroxy-2-nonenal-modified α-synuclein oligomers.

Sardar Sinha M, Villamil Giraldo AM, Öllinger K, Hallbeck M, Civitelli L.

Biochim Biophys Acta Mol Basis Dis. 2018 Sep;1864(9 Pt B):3060-3068. doi: 10.1016/j.bbadis.2018.06.020. Epub 2018 Jun 27.

18.

α-synuclein and synapsin III cooperatively regulate synaptic function in dopamine neurons.

Zaltieri M, Grigoletto J, Longhena F, Navarria L, Favero G, Castrezzati S, Colivicchi MA, Della Corte L, Rezzani R, Pizzi M, Benfenati F, Spillantini MG, Missale C, Spano P, Bellucci A.

J Cell Sci. 2015 Jul 1;128(13):2231-43. doi: 10.1242/jcs.157867. Epub 2015 May 12.

19.

Order and disorder in the physiological membrane binding of α-synuclein.

Fusco G, Sanz-Hernandez M, De Simone A.

Curr Opin Struct Biol. 2018 Feb;48:49-57. doi: 10.1016/j.sbi.2017.09.004. Epub 2017 Nov 5. Review.

PMID:
29100107
20.

DOPAL derived alpha-synuclein oligomers impair synaptic vesicles physiological function.

Plotegher N, Berti G, Ferrari E, Tessari I, Zanetti M, Lunelli L, Greggio E, Bisaglia M, Veronesi M, Girotto S, Dalla Serra M, Perego C, Casella L, Bubacco L.

Sci Rep. 2017 Jan 13;7:40699. doi: 10.1038/srep40699.

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