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Items: 1 to 20 of 99

1.

IAPs Regulate Distinct Innate Immune Pathways to Co-ordinate the Response to Bacterial Peptidoglycans.

Stafford CA, Lawlor KE, Heim VJ, Bankovacki A, Bernardini JP, Silke J, Nachbur U.

Cell Rep. 2018 Feb 6;22(6):1496-1508. doi: 10.1016/j.celrep.2018.01.024.

2.

Unique BIR domain sets determine inhibitor of apoptosis protein-driven cell death and NOD2 complex signal specificity.

Chirieleison SM, Rathkey JK, Abbott DW.

Sci Signal. 2018 Jul 17;11(539). pii: eaao3964. doi: 10.1126/scisignal.aao3964.

3.

Modulation of immune signalling by inhibitors of apoptosis.

Beug ST, Cheung HH, LaCasse EC, Korneluk RG.

Trends Immunol. 2012 Nov;33(11):535-45. doi: 10.1016/j.it.2012.06.004. Epub 2012 Jul 24. Review.

PMID:
22836014
4.

Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2.

Bertrand MJ, Doiron K, Labbé K, Korneluk RG, Barker PA, Saleh M.

Immunity. 2009 Jun 19;30(6):789-801. doi: 10.1016/j.immuni.2009.04.011. Epub 2009 May 21.

5.

Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP2(1).

Blankenship JW, Varfolomeev E, Goncharov T, Fedorova AV, Kirkpatrick DS, Izrael-Tomasevic A, Phu L, Arnott D, Aghajan M, Zobel K, Bazan JF, Fairbrother WJ, Deshayes K, Vucic D.

Biochem J. 2009 Jan 1;417(1):149-60. doi: 10.1042/BJ20081885.

PMID:
18939944
6.

Cellular inhibitors of apoptosis are global regulators of NF-κB and MAPK activation by members of the TNF family of receptors.

Varfolomeev E, Goncharov T, Maecker H, Zobel K, Kömüves LG, Deshayes K, Vucic D.

Sci Signal. 2012 Mar 20;5(216):ra22. doi: 10.1126/scisignal.2001878.

7.

The RING domain of cIAP1 mediates the degradation of RING-bearing inhibitor of apoptosis proteins by distinct pathways.

Cheung HH, Plenchette S, Kern CJ, Mahoney DJ, Korneluk RG.

Mol Biol Cell. 2008 Jul;19(7):2729-40. doi: 10.1091/mbc.E08-01-0107. Epub 2008 Apr 23.

8.

The ubiquitin ligase XIAP recruits LUBAC for NOD2 signaling in inflammation and innate immunity.

Damgaard RB, Nachbur U, Yabal M, Wong WW, Fiil BK, Kastirr M, Rieser E, Rickard JA, Bankovacki A, Peschel C, Ruland J, Bekker-Jensen S, Mailand N, Kaufmann T, Strasser A, Walczak H, Silke J, Jost PJ, Gyrd-Hansen M.

Mol Cell. 2012 Jun 29;46(6):746-58. doi: 10.1016/j.molcel.2012.04.014. Epub 2012 May 17.

9.

Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2.

Darding M, Feltham R, Tenev T, Bianchi K, Benetatos C, Silke J, Meier P.

Cell Death Differ. 2011 Aug;18(8):1376-86. doi: 10.1038/cdd.2011.10. Epub 2011 Feb 18.

10.

cIAP1, cIAP2, and XIAP act cooperatively via nonredundant pathways to regulate genotoxic stress-induced nuclear factor-kappaB activation.

Jin HS, Lee DH, Kim DH, Chung JH, Lee SJ, Lee TH.

Cancer Res. 2009 Mar 1;69(5):1782-91. doi: 10.1158/0008-5472.CAN-08-2256. Epub 2009 Feb 17.

11.

Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling.

Goncharov T, Hedayati S, Mulvihill MM, Izrael-Tomasevic A, Zobel K, Jeet S, Fedorova AV, Eidenschenk C, deVoss J, Yu K, Shaw AS, Kirkpatrick DS, Fairbrother WJ, Deshayes K, Vucic D.

Mol Cell. 2018 Feb 15;69(4):551-565.e7. doi: 10.1016/j.molcel.2018.01.016.

12.

Inhibitors of apoptosis (IAPs) regulate intestinal immunity and inflammatory bowel disease (IBD) inflammation.

Pedersen J, LaCasse EC, Seidelin JB, Coskun M, Nielsen OH.

Trends Mol Med. 2014 Nov;20(11):652-65. doi: 10.1016/j.molmed.2014.09.006. Epub 2014 Oct 1. Review.

PMID:
25282548
13.

c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation.

Varfolomeev E, Goncharov T, Fedorova AV, Dynek JN, Zobel K, Deshayes K, Fairbrother WJ, Vucic D.

J Biol Chem. 2008 Sep 5;283(36):24295-9. doi: 10.1074/jbc.C800128200. Epub 2008 Jul 11.

14.

Inhibitor of apoptosis (IAP) proteins in regulation of inflammation and innate immunity.

Damgaard RB, Gyrd-Hansen M.

Discov Med. 2011 Mar;11(58):221-31. Review.

15.

Inhibitor of apoptosis proteins as novel targets in inflammatory processes.

Mayer BA, Rehberg M, Erhardt A, Wolf A, Reichel CA, Kracht M, Krombach F, Tiegs G, Zahler S, Vollmar AM, Fürst R.

Arterioscler Thromb Vasc Biol. 2011 Oct;31(10):2240-50. doi: 10.1161/ATVBAHA.111.234294. Epub 2011 Aug 4.

PMID:
21817100
16.

IAP family of cell death and signaling regulators.

Silke J, Vucic D.

Methods Enzymol. 2014;545:35-65. doi: 10.1016/B978-0-12-801430-1.00002-0. Review.

PMID:
25065885
17.

IAPs limit activation of RIP kinases by TNF receptor 1 during development.

Moulin M, Anderton H, Voss AK, Thomas T, Wong WW, Bankovacki A, Feltham R, Chau D, Cook WD, Silke J, Vaux DL.

EMBO J. 2012 Apr 4;31(7):1679-91. doi: 10.1038/emboj.2012.18. Epub 2012 Feb 10.

18.

Recent advances in understanding inhibitor of apoptosis proteins.

Lalaoui N, Vaux DL.

F1000Res. 2018 Dec 3;7. pii: F1000 Faculty Rev-1889. doi: 10.12688/f1000research.16439.1. eCollection 2018. Review.

19.

Roles of c-IAP proteins in TNF receptor family activation of NF-κB signaling.

Varfolomeev E, Goncharov T, Vucic D.

Methods Mol Biol. 2015;1280:269-82. doi: 10.1007/978-1-4939-2422-6_15.

PMID:
25736754
20.

Tumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding.

Feltham R, Moulin M, Vince JE, Mace PD, Wong WW, Anderton H, Day CL, Vaux DL, Silke J.

J Biol Chem. 2010 Jun 4;285(23):17525-36. doi: 10.1074/jbc.M109.087635. Epub 2010 Mar 30. Erratum in: J Biol Chem. 2017 Aug 25;292(34):14310.

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