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Items: 1 to 20 of 121

1.

Aryl thiosemicarbazones for the treatment of trypanosomatidic infections.

Linciano P, Moraes CB, Alcantara LM, Franco CH, Pascoalino B, Freitas-Junior LH, Macedo S, Santarem N, Cordeiro-da-Silva A, Gul S, Witt G, Kuzikov M, Ellinger B, Ferrari S, Luciani R, Quotadamo A, Costantino L, Costi MP.

Eur J Med Chem. 2018 Feb 25;146:423-434. doi: 10.1016/j.ejmech.2018.01.043. Epub 2018 Jan 31.

PMID:
29407968
2.

Novel 3,4-methylenedioxyde-6-X-benzaldehyde-thiosemicarbazones: Synthesis and antileishmanial effects against Leishmania amazonensis.

de Melos JL, Torres-Santos EC, Faiões Vdos S, Del Cistia Cde N, Sant'Anna CM, Rodrigues-Santos CE, Echevarria A.

Eur J Med Chem. 2015 Oct 20;103:409-17. doi: 10.1016/j.ejmech.2015.09.009. Epub 2015 Sep 8.

PMID:
26375353
3.

Efficacy of a series of alpha-pyrone derivatives against Leishmania (L.) infantum and Trypanosoma cruzi.

Tempone AG, Ferreira DD, Lima ML, Costa Silva TA, Borborema SET, Reimão JQ, Galuppo MK, Guerra JM, Russell AJ, Wynne GM, Lai RYL, Cadelis MM, Copp BR.

Eur J Med Chem. 2017 Oct 20;139:947-960. doi: 10.1016/j.ejmech.2017.08.055. Epub 2017 Sep 1.

PMID:
28881289
4.

Multicomponent reaction-based synthesis and biological evaluation of tricyclic heterofused quinolines with multi-trypanosomatid activity.

Di Pietro O, Vicente-García E, Taylor MC, Berenguer D, Viayna E, Lanzoni A, Sola I, Sayago H, Riera C, Fisa R, Clos MV, Pérez B, Kelly JM, Lavilla R, Muñoz-Torrero D.

Eur J Med Chem. 2015 Nov 13;105:120-37. doi: 10.1016/j.ejmech.2015.10.007. Epub 2015 Oct 19.

5.

Conformational restriction of aryl thiosemicarbazones produces potent and selective anti-Trypanosoma cruzi compounds which induce apoptotic parasite death.

Magalhaes Moreira DR, de Oliveira AD, Teixeira de Moraes Gomes PA, de Simone CA, Villela FS, Ferreira RS, da Silva AC, dos Santos TA, Brelaz de Castro MC, Pereira VR, Leite AC.

Eur J Med Chem. 2014 Mar 21;75:467-78. doi: 10.1016/j.ejmech.2014.02.001. Epub 2014 Feb 3.

PMID:
24561675
6.

Designing and exploring active N'-[(5-nitrofuran-2-yl) methylene] substituted hydrazides against three Trypanosoma cruzi strains more prevalent in Chagas disease patients.

Palace-Berl F, Pasqualoto KF, Jorge SD, Zingales B, Zorzi RR, Silva MN, Ferreira AK, de Azevedo RA, Teixeira SF, Tavares LC.

Eur J Med Chem. 2015;96:330-9. doi: 10.1016/j.ejmech.2015.03.066. Epub 2015 Apr 1.

PMID:
25899337
7.

Antiprotozoal glutathione derivatives with flagellar membrane binding activity against T. brucei rhodesiense.

Daunes S, Yardley V, Croft SL, D'Silva C.

Bioorg Med Chem. 2017 Feb 15;25(4):1329-1340. doi: 10.1016/j.bmc.2016.12.016. Epub 2016 Dec 18.

8.

Synthesis and structure-activity relationship study of a new series of antiparasitic aryloxyl thiosemicarbazones inhibiting Trypanosoma cruzi cruzain.

Espíndola JW, Cardoso MV, Filho GB, Oliveira E Silva DA, Moreira DR, Bastos TM, Simone CA, Soares MB, Villela FS, Ferreira RS, Castro MC, Pereira VR, Murta SM, Sales Junior PA, Romanha AJ, Leite AC.

Eur J Med Chem. 2015 Aug 28;101:818-35. doi: 10.1016/j.ejmech.2015.06.048. Epub 2015 Jul 3.

PMID:
26231082
9.

Antitrypanosomal activity of 5-nitro-2-aminothiazole-based compounds.

Papadopoulou MV, Bloomer WD, Rosenzweig HS, Wilkinson SR, Szular J, Kaiser M.

Eur J Med Chem. 2016 Jul 19;117:179-86. doi: 10.1016/j.ejmech.2016.04.010. Epub 2016 Apr 8.

10.

Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi.

Greenbaum DC, Mackey Z, Hansell E, Doyle P, Gut J, Caffrey CR, Lehrman J, Rosenthal PJ, McKerrow JH, Chibale K.

J Med Chem. 2004 Jun 3;47(12):3212-9.

PMID:
15163200
11.

Novel ruthenium(II) cyclopentadienyl thiosemicarbazone compounds with antiproliferative activity on pathogenic trypanosomatid parasites.

Fernández M, Arce ER, Sarniguet C, Morais TS, Tomaz AI, Azar CO, Figueroa R, Diego Maya J, Medeiros A, Comini M, Helena Garcia M, Otero L, Gambino D.

J Inorg Biochem. 2015 Dec;153:306-314. doi: 10.1016/j.jinorgbio.2015.06.018. Epub 2015 Jun 30.

PMID:
26275470
12.

Conjugation to 4-aminoquinoline improves the anti-trypanosomal activity of Deferiprone-type iron chelators.

Gehrke SS, Pinto EG, Steverding D, Pleban K, Tempone AG, Hider RC, Wagner GK.

Bioorg Med Chem. 2013 Feb 1;21(3):805-13. doi: 10.1016/j.bmc.2012.11.009. Epub 2012 Nov 27.

PMID:
23266185
13.

1,3,4-Thiadiazole derivatives of R-(+)-limonene benzaldehyde-thiosemicarbazones cause death in Trypanosoma cruzi through oxidative stress.

Martins SC, Lazarin-Bidóia D, Desoti VC, Falzirolli H, da Silva CC, Ueda-Nakamura T, Silva SO, Nakamura CV.

Microbes Infect. 2016 Dec;18(12):787-797. doi: 10.1016/j.micinf.2016.07.007. Epub 2016 Jul 30.

14.

New antiprotozoal agents: their synthesis and biological evaluations.

Upadhayaya RS, Dixit SS, Földesi A, Chattopadhyaya J.

Bioorg Med Chem Lett. 2013 May 1;23(9):2750-8. doi: 10.1016/j.bmcl.2013.02.054. Epub 2013 Feb 22.

PMID:
23518280
15.

Prospects of an alternative treatment against Trypanosoma cruzi based on abietic acid derivatives show promising results in Balb/c mouse model.

Olmo F, Guardia JJ, Marin C, Messouri I, Rosales MJ, Urbanová K, Chayboun I, Chahboun R, Alvarez-Manzaneda EJ, Sánchez-Moreno M.

Eur J Med Chem. 2015 Jan 7;89:683-90. doi: 10.1016/j.ejmech.2014.11.004. Epub 2014 Nov 3.

PMID:
25462275
16.

Design, synthesis and biological evaluation of new aryl thiosemicarbazone as antichagasic candidates.

Blau L, Menegon RF, Trossini GH, Molino JV, Vital DG, Cicarelli RM, Passerini GD, Bosquesi PL, Chin CM.

Eur J Med Chem. 2013 Sep;67:142-51. doi: 10.1016/j.ejmech.2013.04.022. Epub 2013 May 20.

PMID:
23851115
17.

Triclosan-caffeic acid hybrids: Synthesis, leishmanicidal, trypanocidal and cytotoxic activities.

Otero E, García E, Palacios G, Yepes LM, Carda M, Agut R, Vélez ID, Cardona WI, Robledo SM.

Eur J Med Chem. 2017 Dec 1;141:73-83. doi: 10.1016/j.ejmech.2017.09.064. Epub 2017 Sep 29.

PMID:
29028533
18.

Synthesis, docking, and in vitro activity of thiosemicarbazones, aminoacyl-thiosemicarbazides and acyl-thiazolidones against Trypanosoma cruzi.

Leite AC, de Lima RS, Moreira DR, Cardoso MV, Gouveia de Brito AC, Farias Dos Santos LM, Hernandes MZ, Kiperstok AC, de Lima RS, Soares MB.

Bioorg Med Chem. 2006 Jun 1;14(11):3749-57. Epub 2006 Feb 3.

PMID:
16458521
19.

Development of a Focused Library of Triazole-Linked Privileged-Structure-Based Conjugates Leading to the Discovery of Novel Phenotypic Hits against Protozoan Parasitic Infections.

Uliassi E, Piazzi L, Belluti F, Mazzanti A, Kaiser M, Brun R, Moraes CB, Freitas-Junior LH, Gul S, Kuzikov M, Ellinger B, Borsari C, Costi MP, Bolognesi ML.

ChemMedChem. 2018 Apr 6;13(7):678-683. doi: 10.1002/cmdc.201700786. Epub 2018 Feb 16.

PMID:
29451361
20.

New thiadiazine derivatives with activity against Trypanosoma cruzi amastigotes.

Muelas S, Di Maio R, Cerecetto H, Seoane G, Ochoa C, Escario JA, Gómez-Barrio A.

Folia Parasitol (Praha). 2001;48(2):105-8.

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