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Items: 1 to 20 of 101

1.

Shared genetic effects on chromatin and gene expression indicate a role for enhancer priming in immune response.

Alasoo K, Rodrigues J, Mukhopadhyay S, Knights AJ, Mann AL, Kundu K; HIPSCI Consortium, Hale C, Dougan G, Gaffney DJ.

Nat Genet. 2018 Mar;50(3):424-431. doi: 10.1038/s41588-018-0046-7. Epub 2018 Jan 29.

PMID:
29379200
2.

Maps of open chromatin highlight cell type-restricted patterns of regulatory sequence variation at hematological trait loci.

Paul DS, Albers CA, Rendon A, Voss K, Stephens J; HaemGen Consortium, van der Harst P, Chambers JC, Soranzo N, Ouwehand WH, Deloukas P.

Genome Res. 2013 Jul;23(7):1130-41. doi: 10.1101/gr.155127.113. Epub 2013 Apr 9.

3.

Fine-mapping cis-regulatory variants in diverse human populations.

Tehranchi A, Hie B, Dacre M, Kaplow I, Pettie K, Combs P, Fraser HB.

Elife. 2019 Jan 16;8. pii: e39595. doi: 10.7554/eLife.39595.

4.

DNase‚ÄČI sensitivity QTLs are a major determinant of human expression variation.

Degner JF, Pai AA, Pique-Regi R, Veyrieras JB, Gaffney DJ, Pickrell JK, De Leon S, Michelini K, Lewellen N, Crawford GE, Stephens M, Gilad Y, Pritchard JK.

Nature. 2012 Feb 5;482(7385):390-4. doi: 10.1038/nature10808.

5.

Genetic and epigenetic fine mapping of causal autoimmune disease variants.

Farh KK, Marson A, Zhu J, Kleinewietfeld M, Housley WJ, Beik S, Shoresh N, Whitton H, Ryan RJ, Shishkin AA, Hatan M, Carrasco-Alfonso MJ, Mayer D, Luckey CJ, Patsopoulos NA, De Jager PL, Kuchroo VK, Epstein CB, Daly MJ, Hafler DA, Bernstein BE.

Nature. 2015 Feb 19;518(7539):337-43. doi: 10.1038/nature13835. Epub 2014 Oct 29.

6.

Type 2 Diabetes-Associated Genetic Variants Regulate Chromatin Accessibility in Human Islets.

Khetan S, Kursawe R, Youn A, Lawlor N, Jillette A, Marquez EJ, Ucar D, Stitzel ML.

Diabetes. 2018 Nov;67(11):2466-2477. doi: 10.2337/db18-0393. Epub 2018 Sep 4.

PMID:
30181159
7.

Changes in immunoglobulin-nucleoprotein complex structure mapped by chromatin immunoprecipitation.

McDevit DC, Nikolajczyk BS.

Mol Immunol. 2006 Apr;43(10):1541-8. Epub 2005 Nov 28.

PMID:
16313959
8.

Lipid-induced epigenomic changes in human macrophages identify a coronary artery disease-associated variant that regulates PPAP2B Expression through Altered C/EBP-beta binding.

Reschen ME, Gaulton KJ, Lin D, Soilleux EJ, Morris AJ, Smyth SS, O'Callaghan CA.

PLoS Genet. 2015 Apr 2;11(4):e1005061. doi: 10.1371/journal.pgen.1005061. eCollection 2015 Apr.

9.

Integrative modeling of eQTLs and cis-regulatory elements suggests mechanisms underlying cell type specificity of eQTLs.

Brown CD, Mangravite LM, Engelhardt BE.

PLoS Genet. 2013;9(8):e1003649. doi: 10.1371/journal.pgen.1003649. Epub 2013 Aug 1.

10.

PU.1 as a chromatin accessibility factor for immunoglobulin genes.

Marecki S, McCarthy KM, Nikolajczyk BS.

Mol Immunol. 2004 Jan;40(10):723-31.

PMID:
14644098
11.

Genetic risk for Alzheimer's disease is concentrated in specific macrophage and microglial transcriptional networks.

Tansey KE, Cameron D, Hill MJ.

Genome Med. 2018 Feb 26;10(1):14. doi: 10.1186/s13073-018-0523-8.

12.

Cell Specificity of Human Regulatory Annotations and Their Genetic Effects on Gene Expression.

Varshney A, VanRenterghem H, Orchard P, Boyle AP, Stitzel ML, Ucar D, Parker SCJ.

Genetics. 2019 Feb;211(2):549-562. doi: 10.1534/genetics.118.301525. Epub 2018 Dec 28.

PMID:
30593493
13.

A developmentally modulated chromatin structure at the mouse immunoglobulin kappa 3' enhancer.

Roque MC, Smith PA, Blasquez VC.

Mol Cell Biol. 1996 Jun;16(6):3138-55.

14.

A two-step, PU.1-dependent mechanism for developmentally regulated chromatin remodeling and transcription of the c-fms gene.

Krysinska H, Hoogenkamp M, Ingram R, Wilson N, Tagoh H, Laslo P, Singh H, Bonifer C.

Mol Cell Biol. 2007 Feb;27(3):878-87. Epub 2006 Nov 20.

15.

Open chromatin profiling of human postmortem brain infers functional roles for non-coding schizophrenia loci.

Fullard JF, Giambartolomei C, Hauberg ME, Xu K, Voloudakis G, Shao Z, Bare C, Dudley JT, Mattheisen M, Robakis NK, Haroutunian V, Roussos P.

Hum Mol Genet. 2017 May 15;26(10):1942-1951. doi: 10.1093/hmg/ddx103.

16.

Multiple Hepatic Regulatory Variants at the GALNT2 GWAS Locus Associated with High-Density Lipoprotein Cholesterol.

Roman TS, Marvelle AF, Fogarty MP, Vadlamudi S, Gonzalez AJ, Buchkovich ML, Huyghe JR, Fuchsberger C, Jackson AU, Wu Y, Civelek M, Lusis AJ, Gaulton KJ, Sethupathy P, Kangas AJ, Soininen P, Ala-Korpela M, Kuusisto J, Collins FS, Laakso M, Boehnke M, Mohlke KL.

Am J Hum Genet. 2015 Dec 3;97(6):801-15. doi: 10.1016/j.ajhg.2015.10.016.

17.

Cell Type-Specific Chromatin Signatures Underline Regulatory DNA Elements in Human Induced Pluripotent Stem Cells and Somatic Cells.

Zhao MT, Shao NY, Hu S, Ma N, Srinivasan R, Jahanbani F, Lee J, Zhang SL, Snyder MP, Wu JC.

Circ Res. 2017 Nov 10;121(11):1237-1250. doi: 10.1161/CIRCRESAHA.117.311367. Epub 2017 Oct 13.

18.

Multiple NF-kappaB and IFN regulatory factor family transcription factors regulate CCL19 gene expression in human monocyte-derived dendritic cells.

Pietilä TE, Veckman V, Lehtonen A, Lin R, Hiscott J, Julkunen I.

J Immunol. 2007 Jan 1;178(1):253-61.

19.

Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants.

Parker SC, Stitzel ML, Taylor DL, Orozco JM, Erdos MR, Akiyama JA, van Bueren KL, Chines PS, Narisu N; NISC Comparative Sequencing Program, Black BL, Visel A, Pennacchio LA, Collins FS; National Institutes of Health Intramural Sequencing Center Comparative Sequencing Program Authors; NISC Comparative Sequencing Program Authors.

Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17921-6. doi: 10.1073/pnas.1317023110. Epub 2013 Oct 14.

20.

Discovery of stimulation-responsive immune enhancers with CRISPR activation.

Simeonov DR, Gowen BG, Boontanrart M, Roth TL, Gagnon JD, Mumbach MR, Satpathy AT, Lee Y, Bray NL, Chan AY, Lituiev DS, Nguyen ML, Gate RE, Subramaniam M, Li Z, Woo JM, Mitros T, Ray GJ, Curie GL, Naddaf N, Chu JS, Ma H, Boyer E, Van Gool F, Huang H, Liu R, Tobin VR, Schumann K, Daly MJ, Farh KK, Ansel KM, Ye CJ, Greenleaf WJ, Anderson MS, Bluestone JA, Chang HY, Corn JE, Marson A.

Nature. 2017 Sep 7;549(7670):111-115. doi: 10.1038/nature23875. Epub 2017 Aug 30. Erratum in: Nature. 2018 Jul;559(7715):E13.

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