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Items: 1 to 20 of 100

1.

Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics.

Cowell AN, Istvan ES, Lukens AK, Gomez-Lorenzo MG, Vanaerschot M, Sakata-Kato T, Flannery EL, Magistrado P, Owen E, Abraham M, LaMonte G, Painter HJ, Williams RM, Franco V, Linares M, Arriaga I, Bopp S, Corey VC, Gnädig NF, Coburn-Flynn O, Reimer C, Gupta P, Murithi JM, Moura PA, Fuchs O, Sasaki E, Kim SW, Teng CH, Wang LT, Akidil A, Adjalley S, Willis PA, Siegel D, Tanaseichuk O, Zhong Y, Zhou Y, Llinás M, Ottilie S, Gamo FJ, Lee MCS, Goldberg DE, Fidock DA, Wirth DF, Winzeler EA.

Science. 2018 Jan 12;359(6372):191-199. doi: 10.1126/science.aan4472.

2.

Malaria parasite genome scan: insights into antimalarial resistance.

Gupta B, Awasthi G, Das A.

Parasitol Res. 2010 Jul;107(2):495-9. doi: 10.1007/s00436-010-1917-8. Epub 2010 May 25.

PMID:
20499094
3.

Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets.

Yuan J, Cheng KC, Johnson RL, Huang R, Pattaradilokrat S, Liu A, Guha R, Fidock DA, Inglese J, Wellems TE, Austin CP, Su XZ.

Science. 2011 Aug 5;333(6043):724-9. doi: 10.1126/science.1205216.

4.

Microbiology. Exploiting malaria drug resistance to our advantage.

Cammack N.

Science. 2011 Aug 5;333(6043):705-6. doi: 10.1126/science.1210875. No abstract available.

PMID:
21817037
5.

Modulation of PF10_0355 (MSPDBL2) alters Plasmodium falciparum response to antimalarial drugs.

Van Tyne D, Uboldi AD, Healer J, Cowman AF, Wirth DF.

Antimicrob Agents Chemother. 2013 Jul;57(7):2937-41. doi: 10.1128/AAC.02574-12. Epub 2013 Apr 15.

6.

Comparative assessment on the prevalence of mutations in the Plasmodium falciparum drug-resistant genes in two different ecotypes of Odisha state, India.

Kar NP, Chauhan K, Nanda N, Kumar A, Carlton JM, Das A.

Infect Genet Evol. 2016 Jul;41:47-55. doi: 10.1016/j.meegid.2016.03.014. Epub 2016 Mar 15.

7.

Population genetics: malaria variorum.

Clark AG.

Nature. 2002 Jul 18;418(6895):283-5. No abstract available.

PMID:
12124606
8.

Suppression of Drug Resistance Reveals a Genetic Mechanism of Metabolic Plasticity in Malaria Parasites.

Guggisberg AM, Frasse PM, Jezewski AJ, Kafai NM, Gandhi AY, Erlinger SJ, Odom John AR.

MBio. 2018 Nov 13;9(6). pii: e01193-18. doi: 10.1128/mBio.01193-18.

9.

Recurrent gene amplification and soft selective sweeps during evolution of multidrug resistance in malaria parasites.

Nair S, Nash D, Sudimack D, Jaidee A, Barends M, Uhlemann AC, Krishna S, Nosten F, Anderson TJ.

Mol Biol Evol. 2007 Feb;24(2):562-73. Epub 2006 Nov 23.

PMID:
17124182
10.

Evidence of a Mild Mutator Phenotype in Cambodian Plasmodium falciparum Malaria Parasites.

Lee AH, Fidock DA.

PLoS One. 2016 Apr 21;11(4):e0154166. doi: 10.1371/journal.pone.0154166. eCollection 2016.

11.

Genetic and genomic approaches for the discovery of parasite genes involved in antimalarial drug resistance.

Mwangi JM, Ranford-Cartwright LC.

Parasitology. 2013 Oct;140(12):1455-67. doi: 10.1017/S0031182013000954. Epub 2013 Aug 9. Review.

PMID:
23931581
12.
13.

Genetic diversity and chloroquine selective sweeps in Plasmodium falciparum.

Wootton JC, Feng X, Ferdig MT, Cooper RA, Mu J, Baruch DI, Magill AJ, Su XZ.

Nature. 2002 Jul 18;418(6895):320-3.

PMID:
12124623
14.

Microsatellite analysis of chloroquine resistance associated alleles and neutral loci reveal genetic structure of Indian Plasmodium falciparum.

Mallick PK, Sutton PL, Singh R, Singh OP, Dash AP, Singh AK, Carlton JM, Bhasin VK.

Infect Genet Evol. 2013 Oct;19:164-75. doi: 10.1016/j.meegid.2013.07.009. Epub 2013 Jul 17.

15.

Altered Plasmodium falciparum Sensitivity to the Antiretroviral Protease Inhibitor Lopinavir Associated with Polymorphisms in pfmdr1.

Sonoiki E, Nsanzabana C, Legac J, Sindhe KM, DeRisi J, Rosenthal PJ.

Antimicrob Agents Chemother. 2016 Dec 27;61(1). pii: e01949-16. doi: 10.1128/AAC.01949-16. Print 2017 Jan.

16.

Role of pfmdr1 amplification and expression in induction of resistance to artemisinin derivatives in Plasmodium falciparum.

Chavchich M, Gerena L, Peters J, Chen N, Cheng Q, Kyle DE.

Antimicrob Agents Chemother. 2010 Jun;54(6):2455-64. doi: 10.1128/AAC.00947-09. Epub 2010 Mar 29.

17.

Advances in understanding the genetic basis of antimalarial drug resistance.

Ekland EH, Fidock DA.

Curr Opin Microbiol. 2007 Aug;10(4):363-70. Epub 2007 Aug 20. Review.

18.

Updates on k13 mutant alleles for artemisinin resistance in Plasmodium falciparum.

Zaw MT, Emran NA, Lin Z.

J Microbiol Immunol Infect. 2018 Apr;51(2):159-165. doi: 10.1016/j.jmii.2017.06.009. Epub 2017 Jun 29. Review.

19.

Novel Plasmodium falciparum metabolic network reconstruction identifies shifts associated with clinical antimalarial resistance.

Carey MA, Papin JA, Guler JL.

BMC Genomics. 2017 Jul 19;18(1):543. doi: 10.1186/s12864-017-3905-1.

20.

Last parasite standing.

Rutledge GG, Otto TD.

Nat Rev Microbiol. 2016 Dec 9;15(1):4. doi: 10.1038/nrmicro.2016.181.

PMID:
27932794

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