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The Effect of Acetaminophen on Temperature in Critically Ill Children: A Retrospective Analysis of Over 50,000 Doses.

Ray S, Rogers L, Brown KL, Peters MJ.

Pediatr Crit Care Med. 2018 Mar;19(3):204-209. doi: 10.1097/PCC.0000000000001426.


Effects of IV Acetaminophen on Core Body Temperature and Hemodynamic Responses in Febrile Critically Ill Adults: A Randomized Controlled Trial.

Schell-Chaple HM, Liu KD, Matthay MA, Sessler DI, Puntillo KA.

Crit Care Med. 2017 Jul;45(7):1199-1207. doi: 10.1097/CCM.0000000000002340.


Paracetamol therapy for septic critically ill patients: a retrospective observational study.

Selladurai S, Eastwood GM, Bailey M, Bellomo R.

Crit Care Resusc. 2011 Sep;13(3):181-6.


Association of body temperature and antipyretic treatments with mortality of critically ill patients with and without sepsis: multi-centered prospective observational study.

Lee BH, Inui D, Suh GY, Kim JY, Kwon JY, Park J, Tada K, Tanaka K, Ietsugu K, Uehara K, Dote K, Tajimi K, Morita K, Matsuo K, Hoshino K, Hosokawa K, Lee KH, Lee KM, Takatori M, Nishimura M, Sanui M, Ito M, Egi M, Honda N, Okayama N, Shime N, Tsuruta R, Nogami S, Yoon SH, Fujitani S, Koh SO, Takeda S, Saito S, Hong SJ, Yamamoto T, Yokoyama T, Yamaguchi T, Nishiyama T, Igarashi T, Kakihana Y, Koh Y; Fever and Antipyretic in Critically ill patients Evaluation (FACE) Study Group.

Crit Care. 2012 Feb 28;16(1):R33. doi: 10.1186/cc11211. Erratum in: Crit Care. 2012;16(1):450.


Attitudes towards fever amongst UK paediatric intensive care staff.

Brick T, Agbeko RS, Davies P, Davis PJ, Deep A, Fortune PM, Inwald DP, Jones A, Levin R, Morris KP, Pappachan J, Ray S, Tibby SM, Tume LN, Peters MJ; UK Paediatric Intensive Care Society Study Group (PICS-SG).

Eur J Pediatr. 2017 Mar;176(3):423-427. doi: 10.1007/s00431-016-2844-1. Epub 2017 Jan 18.


Assessment of the safety and feasibility of administering anti-pyretic therapy in critically ill adults: study protocol of a randomized trial.

Niven DJ, Léger C, Kubes P, Stelfox HT, Laupland KB.

BMC Res Notes. 2012 Mar 16;5:147. doi: 10.1186/1756-0500-5-147.


Acetaminophen has limited antipyretic activity in critically ill patients.

Greenberg RS, Chen H, Hasday JD.

J Crit Care. 2010 Jun;25(2):363.e1-7. doi: 10.1016/j.jcrc.2009.07.005. Epub 2009 Sep 24.


Paracetamol (Acetaminophen) in stroke 2 (PAIS 2): protocol for a randomized, placebo-controlled, double-blind clinical trial to assess the effect of high-dose paracetamol on functional outcome in patients with acute stroke and a body temperature of 36.5 °C or above.

de Ridder IR, de Jong FJ, den Hertog HM, Lingsma HF, van Gemert HM, Schreuder AH, Ruitenberg A, Maasland EL, Saxena R, Oomes P, van Tuijl J, Koudstaal PJ, Kappelle LJ, Algra A, van der Worp HB, Dippel DW.

Int J Stroke. 2015 Apr;10(3):457-62. doi: 10.1111/ijs.12053. Epub 2013 May 22.


[Antipyretics in intensive care patients].

Simon A, Leffler A.

Anaesthesist. 2017 Jul;66(7):511-517. doi: 10.1007/s00101-017-0301-9. Review. German.


Comparison of fever treatments in the critically ill: a pilot study.

Henker R, Rogers S, Kramer DJ, Kelso L, Kerr M, Sereika S.

Am J Crit Care. 2001 Jul;10(4):276-80.


Alternating Acetaminophen and Ibuprofen versus Monotherapies in Improvements of Distress and Reducing Refractory Fever in Febrile Children: A Randomized Controlled Trial.

Luo S, Ran M, Luo Q, Shu M, Guo Q, Zhu Y, Xie X, Zhang C, Wan C.

Paediatr Drugs. 2017 Oct;19(5):479-486. doi: 10.1007/s40272-017-0237-1.


Combined and alternating paracetamol and ibuprofen therapy for febrile children.

Wong T, Stang AS, Ganshorn H, Hartling L, Maconochie IK, Thomsen AM, Johnson DW.

Cochrane Database Syst Rev. 2013 Oct 30;(10):CD009572. doi: 10.1002/14651858.CD009572.pub2. Review.


Different temperature thresholds for antipyretic intervention in critically ill children with fever due to infection: the FEVER feasibility RCT.

Peters MJ, Khan I, Woolfall K, Deja E, Mouncey PR, Wulff J, Mason A, Agbeko R, Draper ES, Fenn B, Gould DW, Koelewyn A, Klein N, Mackerness C, Martin S, O'Neill L, Ramnarayan P, Tibby S, Tume L, Watkins J, Thorburn K, Wellman P, Harrison DA, Rowan KM.

Health Technol Assess. 2019 Feb;23(5):1-148. doi: 10.3310/hta23050.


Acetaminophen for Fever in Critically Ill Patients with Suspected Infection.

Young P, Saxena M, Bellomo R, Freebairn R, Hammond N, van Haren F, Holliday M, Henderson S, Mackle D, McArthur C, McGuinness S, Myburgh J, Weatherall M, Webb S, Beasley R; HEAT Investigators; Australian and New Zealand Intensive Care Society Clinical Trials Group.

N Engl J Med. 2015 Dec 3;373(23):2215-24. doi: 10.1056/NEJMoa1508375. Epub 2015 Oct 5.


A prospective randomized study to evaluate the antipyretic effect of the combination of acetaminophen and ibuprofen in neurological ICU patients.

Mullins ME, Empey M, Jaramillo D, Sosa S, Human T, Diringer MN.

Neurocrit Care. 2011 Dec;15(3):375-8. doi: 10.1007/s12028-011-9533-8.


Determinants of antipyretic misuse in children up to 5 years of age: a cross-sectional study.

Bilenko N, Tessler H, Okbe R, Press J, Gorodischer R.

Clin Ther. 2006 May;28(5):783-93.


Efficacy of standard doses of Ibuprofen alone, alternating, and combined with acetaminophen for the treatment of febrile children.

Paul IM, Sturgis SA, Yang C, Engle L, Watts H, Berlin CM Jr.

Clin Ther. 2010 Dec;32(14):2433-40. doi: 10.1016/j.clinthera.2011.01.006.


Combined and alternating paracetamol and ibuprofen therapy for febrile children.

Wong T, Stang AS, Ganshorn H, Hartling L, Maconochie IK, Thomsen AM, Johnson DW.

Evid Based Child Health. 2014 Sep;9(3):675-729. doi: 10.1002/ebch.1978. Review.


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