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Items: 1 to 20 of 101

1.

IL-11 is a crucial determinant of cardiovascular fibrosis.

Schafer S, Viswanathan S, Widjaja AA, Lim WW, Moreno-Moral A, DeLaughter DM, Ng B, Patone G, Chow K, Khin E, Tan J, Chothani SP, Ye L, Rackham OJL, Ko NSJ, Sahib NE, Pua CJ, Zhen NTG, Xie C, Wang M, Maatz H, Lim S, Saar K, Blachut S, Petretto E, Schmidt S, Putoczki T, Guimarães-Camboa N, Wakimoto H, van Heesch S, Sigmundsson K, Lim SL, Soon JL, Chao VTT, Chua YL, Tan TE, Evans SM, Loh YJ, Jamal MH, Ong KK, Chua KC, Ong BH, Chakaramakkil MJ, Seidman JG, Seidman CE, Hubner N, Sin KYK, Cook SA.

Nature. 2017 Dec 7;552(7683):110-115. doi: 10.1038/nature24676. Epub 2017 Nov 13.

2.

Deletion of interleukin-6 alleviated interstitial fibrosis in streptozotocin-induced diabetic cardiomyopathy of mice through affecting TGFβ1 and miR-29 pathways.

Zhang Y, Wang JH, Zhang YY, Wang YZ, Wang J, Zhao Y, Jin XX, Xue GL, Li PH, Sun YL, Huang QH, Song XT, Zhang ZR, Gao X, Yang BF, Du ZM, Pan ZW.

Sci Rep. 2016 Mar 14;6:23010. doi: 10.1038/srep23010.

3.

Diverse roles of TGF-β receptor II in renal fibrosis and inflammation in vivo and in vitro.

Meng XM, Huang XR, Xiao J, Chen HY, Zhong X, Chung AC, Lan HY.

J Pathol. 2012 Jun;227(2):175-88. doi: 10.1002/path.3976. Epub 2012 Feb 22.

PMID:
22190171
4.

Macrophage-stimulated cardiac fibroblast production of IL-6 is essential for TGF β/Smad activation and cardiac fibrosis induced by angiotensin II.

Ma F, Li Y, Jia L, Han Y, Cheng J, Li H, Qi Y, Du J.

PLoS One. 2012;7(5):e35144. doi: 10.1371/journal.pone.0035144. Epub 2012 May 4.

5.

Astragaloside IV suppresses transforming growth factor-β1 induced fibrosis of cultured mouse renal fibroblasts via inhibition of the MAPK and NF-κB signaling pathways.

Che X, Wang Q, Xie Y, Xu W, Shao X, Mou S, Ni Z.

Biochem Biophys Res Commun. 2015 Sep 4;464(4):1260-1266. doi: 10.1016/j.bbrc.2015.07.116. Epub 2015 Jul 26.

PMID:
26220342
6.

Hyper-responsiveness of IPF/UIP fibroblasts: interplay between TGFbeta1, IL-13 and CCL2.

Murray LA, Argentieri RL, Farrell FX, Bracht M, Sheng H, Whitaker B, Beck H, Tsui P, Cochlin K, Evanoff HL, Hogaboam CM, Das AM.

Int J Biochem Cell Biol. 2008;40(10):2174-82. doi: 10.1016/j.biocel.2008.02.016. Epub 2008 Feb 23.

PMID:
18395486
7.

IL-13 signaling via IL-13R alpha2 induces major downstream fibrogenic factors mediating fibrosis in chronic TNBS colitis.

Fichtner-Feigl S, Young CA, Kitani A, Geissler EK, Schlitt HJ, Strober W.

Gastroenterology. 2008 Dec;135(6):2003-13, 2013.e1-7. doi: 10.1053/j.gastro.2008.08.055. Epub 2008 Sep 11.

PMID:
18938165
8.

Redox control of p53 in the transcriptional regulation of TGF-β1 target genes through SMAD cooperativity.

Overstreet JM, Samarakoon R, Meldrum KK, Higgins PJ.

Cell Signal. 2014 Jul;26(7):1427-36. doi: 10.1016/j.cellsig.2014.02.017. Epub 2014 Mar 5.

9.

Vitamin D inhibition of pro-fibrotic effects of transforming growth factor beta1 in lung fibroblasts and epithelial cells.

Ramirez AM, Wongtrakool C, Welch T, Steinmeyer A, Zügel U, Roman J.

J Steroid Biochem Mol Biol. 2010 Feb 15;118(3):142-50. doi: 10.1016/j.jsbmb.2009.11.004. Epub 2009 Nov 17.

10.

Combined effects of interleukin-1α and transforming growth factor-β1 on modulation of human cardiac fibroblast function.

van Nieuwenhoven FA, Hemmings KE, Porter KE, Turner NA.

Matrix Biol. 2013 Oct-Nov;32(7-8):399-406. doi: 10.1016/j.matbio.2013.03.008. Epub 2013 Apr 12.

11.

FGF23 activates injury-primed renal fibroblasts via FGFR4-dependent signalling and enhancement of TGF-β autoinduction.

Smith ER, Holt SG, Hewitson TD.

Int J Biochem Cell Biol. 2017 Nov;92:63-78. doi: 10.1016/j.biocel.2017.09.009. Epub 2017 Sep 15.

12.

Reduced endoglin activity limits cardiac fibrosis and improves survival in heart failure.

Kapur NK, Wilson S, Yunis AA, Qiao X, Mackey E, Paruchuri V, Baker C, Aronovitz MJ, Karumanchi SA, Letarte M, Kass DA, Mendelsohn ME, Karas RH.

Circulation. 2012 Jun 5;125(22):2728-38. doi: 10.1161/CIRCULATIONAHA.111.080002. Epub 2012 May 16.

13.

Rictor/mTORC2 signaling mediates TGFβ1-induced fibroblast activation and kidney fibrosis.

Li J, Ren J, Liu X, Jiang L, He W, Yuan W, Yang J, Dai C.

Kidney Int. 2015 Sep;88(3):515-27. doi: 10.1038/ki.2015.119. Epub 2015 May 13.

14.

NF-κB-mediated integrin-linked kinase regulation in angiotensin II-induced pro-fibrotic process in cardiac fibroblasts.

Thakur S, Li L, Gupta S.

Life Sci. 2014 Jun 27;107(1-2):68-75. doi: 10.1016/j.lfs.2014.04.030. Epub 2014 May 4.

PMID:
24802124
15.

Autocrine production of IL-11 mediates tumorigenicity in hypoxic cancer cells.

Onnis B, Fer N, Rapisarda A, Perez VS, Melillo G.

J Clin Invest. 2013 Apr;123(4):1615-29. doi: 10.1172/JCI59623. Epub 2013 Mar 15.

16.

Aucubin Protects against TGFβ1-Induced Cardiac Fibroblasts Activation by Mediating the AMPKα/mTOR Signaling Pathway.

Xiao Y, Chang W, Wu QQ, Jiang XH, Duan MX, Jin YG, Tang QZ.

Planta Med. 2018 Jan;84(2):91-99. doi: 10.1055/s-0043-118663. Epub 2017 Aug 25. Erratum in: Planta Med. 2018 Jan;84(2):E2.

PMID:
28841738
17.

Basic fibroblast growth factor expression is increased in human renal fibrogenesis and may mediate autocrine fibroblast proliferation.

Strutz F, Zeisberg M, Hemmerlein B, Sattler B, Hummel K, Becker V, Müller GA.

Kidney Int. 2000 Apr;57(4):1521-38.

18.

Endothelial dysfunction exacerbates renal interstitial fibrosis through enhancing fibroblast Smad3 linker phosphorylation in the mouse obstructed kidney.

Sun YB, Qu X, Li X, Nikolic-Paterson DJ, Li J.

PLoS One. 2013 Dec 31;8(12):e84063. doi: 10.1371/journal.pone.0084063. eCollection 2013.

19.

Protection from fluorescein isothiocyanate-induced fibrosis in IL-13-deficient, but not IL-4-deficient, mice results from impaired collagen synthesis by fibroblasts.

Kolodsick JE, Toews GB, Jakubzick C, Hogaboam C, Moore TA, McKenzie A, Wilke CA, Chrisman CJ, Moore BB.

J Immunol. 2004 Apr 1;172(7):4068-76.

20.

Velvet antler peptide prevents pressure overload-induced cardiac fibrosis via transforming growth factor (TGF)-β1 pathway inhibition.

Zhao L, Mi Y, Guan H, Xu Y, Mei Y.

Eur J Pharmacol. 2016 Jul 15;783:33-46. doi: 10.1016/j.ejphar.2016.04.039. Epub 2016 Apr 21.

PMID:
27108788

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