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Items: 1 to 20 of 102

1.

Pharmacological inhibition of the transcription factor PU.1 in leukemia.

Antony-Debré I, Paul A, Leite J, Mitchell K, Kim HM, Carvajal LA, Todorova TI, Huang K, Kumar A, Farahat AA, Bartholdy B, Narayanagari SR, Chen J, Ambesi-Impiombato A, Ferrando AA, Mantzaris I, Gavathiotis E, Verma A, Will B, Boykin DW, Wilson WD, Poon GM, Steidl U.

J Clin Invest. 2017 Dec 1;127(12):4297-4313. doi: 10.1172/JCI92504. Epub 2017 Oct 30.

2.

Minimal PU.1 reduction induces a preleukemic state and promotes development of acute myeloid leukemia.

Will B, Vogler TO, Narayanagari S, Bartholdy B, Todorova TI, da Silva Ferreira M, Chen J, Yu Y, Mayer J, Barreyro L, Carvajal L, Neriah DB, Roth M, van Oers J, Schaetzlein S, McMahon C, Edelmann W, Verma A, Steidl U.

Nat Med. 2015 Oct;21(10):1172-81. doi: 10.1038/nm.3936. Epub 2015 Sep 7.

3.

Essential role of Jun family transcription factors in PU.1 knockdown-induced leukemic stem cells.

Steidl U, Rosenbauer F, Verhaak RG, Gu X, Ebralidze A, Otu HH, Klippel S, Steidl C, Bruns I, Costa DB, Wagner K, Aivado M, Kobbe G, Valk PJ, Passegué E, Libermann TA, Delwel R, Tenen DG.

Nat Genet. 2006 Nov;38(11):1269-77. Epub 2006 Oct 15.

PMID:
17041602
4.

Down-regulation of Notch-1 expression decreases PU.1-mediated myeloid differentiation signaling in acute myeloid leukemia.

Chen PM, Yen CC, Wang WS, Lin YJ, Chu CJ, Chiou TJ, Liu JH, Yang MH.

Int J Oncol. 2008 Jun;32(6):1335-41.

PMID:
18497996
5.

Aggressive acute myeloid leukemia in PU.1/p53 double-mutant mice.

Basova P, Pospisil V, Savvulidi F, Burda P, Vargova K, Stanek L, Dluhosova M, Kuzmova E, Jonasova A, Steidl U, Laslo P, Stopka T.

Oncogene. 2014 Sep 25;33(39):4735-45. doi: 10.1038/onc.2013.414. Epub 2013 Oct 14.

PMID:
24121269
6.

The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia.

Vangala RK, Heiss-Neumann MS, Rangatia JS, Singh SM, Schoch C, Tenen DG, Hiddemann W, Behre G.

Blood. 2003 Jan 1;101(1):270-7. Epub 2002 Aug 29.

7.

A distal single nucleotide polymorphism alters long-range regulation of the PU.1 gene in acute myeloid leukemia.

Steidl U, Steidl C, Ebralidze A, Chapuy B, Han HJ, Will B, Rosenbauer F, Becker A, Wagner K, Koschmieder S, Kobayashi S, Costa DB, Schulz T, O'Brien KB, Verhaak RG, Delwel R, Haase D, Trümper L, Krauter J, Kohwi-Shigematsu T, Griesinger F, Tenen DG.

J Clin Invest. 2007 Sep;117(9):2611-20.

8.

Upregulation of c-myc gene accompanied by PU.1 deficiency in radiation-induced acute myeloid leukemia in mice.

Hirouchi T, Takabatake T, Yoshida K, Nitta Y, Nakamura M, Tanaka S, Ichinohe K, Oghiso Y, Tanaka K.

Exp Hematol. 2008 Jul;36(7):871-85. doi: 10.1016/j.exphem.2008.01.015. Epub 2008 Apr 2.

PMID:
18375040
9.

NF-κB/STAT5/miR-155 network targets PU.1 in FLT3-ITD-driven acute myeloid leukemia.

Gerloff D, Grundler R, Wurm AA, Bräuer-Hartmann D, Katzerke C, Hartmann JU, Madan V, Müller-Tidow C, Duyster J, Tenen DG, Niederwieser D, Behre G.

Leukemia. 2015 Mar;29(3):535-47. doi: 10.1038/leu.2014.231. Epub 2014 Aug 5.

10.

The anti-apoptotic gene BCL2A1 is a novel transcriptional target of PU.1.

Jenal M, Batliner J, Reddy VA, Haferlach T, Tobler A, Fey MF, Torbett BE, Tschan MP.

Leukemia. 2010 May;24(5):1073-6. doi: 10.1038/leu.2010.26. Epub 2010 Mar 4. No abstract available.

PMID:
20200559
11.

PU.1-mediated upregulation of CSF1R is crucial for leukemia stem cell potential induced by MOZ-TIF2.

Aikawa Y, Katsumoto T, Zhang P, Shima H, Shino M, Terui K, Ito E, Ohno H, Stanley ER, Singh H, Tenen DG, Kitabayashi I.

Nat Med. 2010 May;16(5):580-5, 1p following 585. doi: 10.1038/nm.2122. Epub 2010 Apr 25.

12.

Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1.

Rosenbauer F, Wagner K, Kutok JL, Iwasaki H, Le Beau MM, Okuno Y, Akashi K, Fiering S, Tenen DG.

Nat Genet. 2004 Jun;36(6):624-30. Epub 2004 May 16.

PMID:
15146183
13.

The Runx-PU.1 pathway preserves normal and AML/ETO9a leukemic stem cells.

Staber PB, Zhang P, Ye M, Welner RS, Levantini E, Di Ruscio A, Ebralidze AK, Bach C, Zhang H, Zhang J, Vanura K, Delwel R, Yang H, Huang G, Tenen DG.

Blood. 2014 Oct 9;124(15):2391-9. doi: 10.1182/blood-2014-01-550855. Epub 2014 Sep 3.

14.

PU.1 downregulation in murine radiation-induced acute myeloid leukaemia (AML): from molecular mechanism to human AML.

Verbiest T, Bouffler S, Nutt SL, Badie C.

Carcinogenesis. 2015 Apr;36(4):413-9. doi: 10.1093/carcin/bgv016. Epub 2015 Mar 6. Review.

15.

PU.1 and CEBPA expression in acute myeloid leukemia.

D'Alò F, Di Ruscio A, Guidi F, Fabiani E, Greco M, Rumi C, Hohaus S, Voso MT, Leone G.

Leuk Res. 2008 Sep;32(9):1448-53. doi: 10.1016/j.leukres.2008.01.007. Epub 2008 Mar 4.

PMID:
18308386
16.

ATRA resolves the differentiation block in t(15;17) acute myeloid leukemia by restoring PU.1 expression.

Mueller BU, Pabst T, Fos J, Petkovic V, Fey MF, Asou N, Buergi U, Tenen DG.

Blood. 2006 Apr 15;107(8):3330-8. Epub 2005 Dec 13.

17.

PU.1 supports TRAIL-induced cell death by inhibiting NF-κB-mediated cell survival and inducing DR5 expression.

Haimovici A, Humbert M, Federzoni EA, Shan-Krauer D, Brunner T, Frese S, Kaufmann T, Torbett BE, Tschan MP.

Cell Death Differ. 2017 May;24(5):866-877. doi: 10.1038/cdd.2017.40. Epub 2017 Mar 31.

18.

Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia.

Jiang X, Hu C, Ferchen K, Nie J, Cui X, Chen CH, Cheng L, Zuo Z, Seibel W, He C, Tang Y, Skibbe JR, Wunderlich M, Reinhold WC, Dong L, Shen C, Arnovitz S, Ulrich B, Lu J, Weng H, Su R, Huang H, Wang Y, Li C, Qin X, Mulloy JC, Zheng Y, Diao J, Jin J, Li C, Liu PP, He C, Chen Y, Chen J.

Nat Commun. 2017 Dec 13;8(1):2099. doi: 10.1038/s41467-017-02290-w. Erratum in: Nat Commun. 2018 Feb 9;9(1):670.

19.

PU.1 binding to the p53 family of tumor suppressors impairs their transcriptional activity.

Tschan MP, Reddy VA, Ress A, Arvidsson G, Fey MF, Torbett BE.

Oncogene. 2008 May 29;27(24):3489-93. doi: 10.1038/sj.onc.1211004. Epub 2008 Jan 14.

PMID:
18193090
20.

GATA-1 Inhibits PU.1 Gene via DNA and Histone H3K9 Methylation of Its Distal Enhancer in Erythroleukemia.

Burda P, Vargova J, Curik N, Salek C, Papadopoulos GL, Strouboulis J, Stopka T.

PLoS One. 2016 Mar 24;11(3):e0152234. doi: 10.1371/journal.pone.0152234. eCollection 2016.

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