Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 129

1.

The Role of Disulfide Bond Replacements in Analogues of the Tarantula Toxin ProTx-II and Their Effects on Inhibition of the Voltage-Gated Sodium Ion Channel Nav1.7.

Wright ZVF, McCarthy S, Dickman R, Reyes FE, Sanchez-Martinez S, Cryar A, Kilford I, Hall A, Takle AK, Topf M, Gonen T, Thalassinos K, Tabor AB.

J Am Chem Soc. 2017 Sep 20;139(37):13063-13075. doi: 10.1021/jacs.7b06506. Epub 2017 Sep 7.

2.

Studies examining the relationship between the chemical structure of protoxin II and its activity on voltage gated sodium channels.

Park JH, Carlin KP, Wu G, Ilyin VI, Musza LL, Blake PR, Kyle DJ.

J Med Chem. 2014 Aug 14;57(15):6623-31. doi: 10.1021/jm500687u. Epub 2014 Jul 24.

PMID:
25026046
3.

Identification and Characterization of ProTx-III [μ-TRTX-Tp1a], a New Voltage-Gated Sodium Channel Inhibitor from Venom of the Tarantula Thrixopelma pruriens.

Cardoso FC, Dekan Z, Rosengren KJ, Erickson A, Vetter I, Deuis JR, Herzig V, Alewood PF, King GF, Lewis RJ.

Mol Pharmacol. 2015 Aug;88(2):291-303. doi: 10.1124/mol.115.098178. Epub 2015 May 15.

PMID:
25979003
4.

Structure and function of hainantoxin-III, a selective antagonist of neuronal tetrodotoxin-sensitive voltage-gated sodium channels isolated from the Chinese bird spider Ornithoctonus hainana.

Liu Z, Cai T, Zhu Q, Deng M, Li J, Zhou X, Zhang F, Li D, Li J, Liu Y, Hu W, Liang S.

J Biol Chem. 2013 Jul 12;288(28):20392-403. doi: 10.1074/jbc.M112.426627. Epub 2013 May 23.

5.

Gating modifier toxins isolated from spider venom: Modulation of voltage-gated sodium channels and the role of lipid membranes.

Agwa AJ, Peigneur S, Chow CY, Lawrence N, Craik DJ, Tytgat J, King GF, Henriques ST, Schroeder CI.

J Biol Chem. 2018 Jun 8;293(23):9041-9052. doi: 10.1074/jbc.RA118.002553. Epub 2018 Apr 27.

PMID:
29703751
6.

Two tarantula peptides inhibit activation of multiple sodium channels.

Middleton RE, Warren VA, Kraus RL, Hwang JC, Liu CJ, Dai G, Brochu RM, Kohler MG, Gao YD, Garsky VM, Bogusky MJ, Mehl JT, Cohen CJ, Smith MM.

Biochemistry. 2002 Dec 17;41(50):14734-47.

PMID:
12475222
7.

Interaction of Tarantula Venom Peptide ProTx-II with Lipid Membranes Is a Prerequisite for Its Inhibition of Human Voltage-gated Sodium Channel NaV1.7.

Henriques ST, Deplazes E, Lawrence N, Cheneval O, Chaousis S, Inserra M, Thongyoo P, King GF, Mark AE, Vetter I, Craik DJ, Schroeder CI.

J Biol Chem. 2016 Aug 12;291(33):17049-65. doi: 10.1074/jbc.M116.729095. Epub 2016 Jun 16.

8.

Three Peptide Modulators of the Human Voltage-Gated Sodium Channel 1.7, an Important Analgesic Target, from the Venom of an Australian Tarantula.

Chow CY, Cristofori-Armstrong B, Undheim EA, King GF, Rash LD.

Toxins (Basel). 2015 Jun 30;7(7):2494-513. doi: 10.3390/toxins7072494.

9.

Modulatory features of the novel spider toxin μ-TRTX-Df1a isolated from the venom of the spider Davus fasciatus.

Cardoso FC, Dekan Z, Smith JJ, Deuis JR, Vetter I, Herzig V, Alewood PF, King GF, Lewis RJ.

Br J Pharmacol. 2017 Aug;174(15):2528-2544. doi: 10.1111/bph.13865. Epub 2017 Jun 27.

10.

A tarantula-venom peptide antagonizes the TRPA1 nociceptor ion channel by binding to the S1-S4 gating domain.

Gui J, Liu B, Cao G, Lipchik AM, Perez M, Dekan Z, Mobli M, Daly NL, Alewood PF, Parker LL, King GF, Zhou Y, Jordt SE, Nitabach MN.

Curr Biol. 2014 Mar 3;24(5):473-83. doi: 10.1016/j.cub.2014.01.013. Epub 2014 Feb 13.

11.

The tarantula toxins ProTx-II and huwentoxin-IV differentially interact with human Nav1.7 voltage sensors to inhibit channel activation and inactivation.

Xiao Y, Blumenthal K, Jackson JO 2nd, Liang S, Cummins TR.

Mol Pharmacol. 2010 Dec;78(6):1124-34. doi: 10.1124/mol.110.066332. Epub 2010 Sep 20.

12.

Engineering potent and selective analogues of GpTx-1, a tarantula venom peptide antagonist of the Na(V)1.7 sodium channel.

Murray JK, Ligutti J, Liu D, Zou A, Poppe L, Li H, Andrews KL, Moyer BD, McDonough SI, Favreau P, Stöcklin R, Miranda LP.

J Med Chem. 2015 Mar 12;58(5):2299-314. doi: 10.1021/jm501765v. Epub 2015 Feb 19.

PMID:
25658507
13.

Insensitivity to pain induced by a potent selective closed-state Nav1.7 inhibitor.

Flinspach M, Xu Q, Piekarz AD, Fellows R, Hagan R, Gibbs A, Liu Y, Neff RA, Freedman J, Eckert WA, Zhou M, Bonesteel R, Pennington MW, Eddinger KA, Yaksh TL, Hunter M, Swanson RV, Wickenden AD.

Sci Rep. 2017 Jan 3;7:39662. doi: 10.1038/srep39662.

14.

Molecular surface of JZTX-V (β-Theraphotoxin-Cj2a) interacting with voltage-gated sodium channel subtype NaV1.4.

Luo J, Zhang Y, Gong M, Lu S, Ma Y, Zeng X, Liang S.

Toxins (Basel). 2014 Jul 23;6(7):2177-93. doi: 10.3390/toxins6072177.

15.

ProTx-I and ProTx-II: gating modifiers of voltage-gated sodium channels.

Priest BT, Blumenthal KM, Smith JJ, Warren VA, Smith MM.

Toxicon. 2007 Feb;49(2):194-201. Epub 2006 Sep 27. Review.

PMID:
17087985
16.

Potency optimization of Huwentoxin-IV on hNav1.7: a neurotoxin TTX-S sodium-channel antagonist from the venom of the Chinese bird-eating spider Selenocosmia huwena.

Revell JD, Lund PE, Linley JE, Metcalfe J, Burmeister N, Sridharan S, Jones C, Jermutus L, Bednarek MA.

Peptides. 2013 Jun;44:40-6. doi: 10.1016/j.peptides.2013.03.011. Epub 2013 Mar 19.

PMID:
23523779
17.

Sustained inhibition of the NaV1.7 sodium channel by engineered dimers of the domain II binding peptide GpTx-1.

Murray JK, Biswas K, Holder JR, Zou A, Ligutti J, Liu D, Poppe L, Andrews KL, Lin FF, Meng SY, Moyer BD, McDonough SI, Miranda LP.

Bioorg Med Chem Lett. 2015 Nov 1;25(21):4866-4871. doi: 10.1016/j.bmcl.2015.06.033. Epub 2015 Jun 16.

PMID:
26112439
18.

Inhibition of sodium channel gating by trapping the domain II voltage sensor with protoxin II.

Sokolov S, Kraus RL, Scheuer T, Catterall WA.

Mol Pharmacol. 2008 Mar;73(3):1020-8. Epub 2007 Dec 21.

PMID:
18156314
19.

Cysteine racemization during the Fmoc solid phase peptide synthesis of the Nav1.7-selective peptide--protoxin II.

Park JH, Carlin KP, Wu G, Ilyin VI, Kyle DJ.

J Pept Sci. 2012 Jul;18(7):442-8. doi: 10.1002/psc.2407. Epub 2012 May 17.

PMID:
22605564
20.

Seven novel modulators of the analgesic target NaV 1.7 uncovered using a high-throughput venom-based discovery approach.

Klint JK, Smith JJ, Vetter I, Rupasinghe DB, Er SY, Senff S, Herzig V, Mobli M, Lewis RJ, Bosmans F, King GF.

Br J Pharmacol. 2015 May;172(10):2445-58. doi: 10.1111/bph.13081. Epub 2015 Mar 4.

Supplemental Content

Support Center