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Items: 1 to 20 of 97

1.

Protein homeostasis of a metastable subproteome associated with Alzheimer's disease.

Kundra R, Ciryam P, Morimoto RI, Dobson CM, Vendruscolo M.

Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):E5703-E5711. doi: 10.1073/pnas.1618417114. Epub 2017 Jun 26.

2.

A transcriptional signature of Alzheimer's disease is associated with a metastable subproteome at risk for aggregation.

Ciryam P, Kundra R, Freer R, Morimoto RI, Dobson CM, Vendruscolo M.

Proc Natl Acad Sci U S A. 2016 Apr 26;113(17):4753-8. doi: 10.1073/pnas.1516604113. Epub 2016 Apr 11.

3.

A protein homeostasis signature in healthy brains recapitulates tissue vulnerability to Alzheimer's disease.

Freer R, Sormanni P, Vecchi G, Ciryam P, Dobson CM, Vendruscolo M.

Sci Adv. 2016 Aug 10;2(8):e1600947. doi: 10.1126/sciadv.1600947. eCollection 2016 Aug.

4.

Increased acetyl and total histone levels in post-mortem Alzheimer's disease brain.

Narayan PJ, Lill C, Faull R, Curtis MA, Dragunow M.

Neurobiol Dis. 2015 Feb;74:281-94. doi: 10.1016/j.nbd.2014.11.023. Epub 2014 Dec 5.

PMID:
25484284
5.

Dissecting phenotypic traits linked to human resilience to Alzheimer's pathology.

Perez-Nievas BG, Stein TD, Tai HC, Dols-Icardo O, Scotton TC, Barroeta-Espar I, Fernandez-Carballo L, de Munain EL, Perez J, Marquie M, Serrano-Pozo A, Frosch MP, Lowe V, Parisi JE, Petersen RC, Ikonomovic MD, López OL, Klunk W, Hyman BT, Gómez-Isla T.

Brain. 2013 Aug;136(Pt 8):2510-26. doi: 10.1093/brain/awt171. Epub 2013 Jul 3.

6.

Tau degradation: the ubiquitin-proteasome system versus the autophagy-lysosome system.

Lee MJ, Lee JH, Rubinsztein DC.

Prog Neurobiol. 2013 Jun;105:49-59. doi: 10.1016/j.pneurobio.2013.03.001. Epub 2013 Mar 23. Review.

PMID:
23528736
7.

The role of protein clearance mechanisms in organismal ageing and age-related diseases.

Vilchez D, Saez I, Dillin A.

Nat Commun. 2014 Dec 8;5:5659. doi: 10.1038/ncomms6659. Review.

PMID:
25482515
8.

Cross-linking of ubiquitin, HSP27, parkin, and alpha-synuclein by gamma-glutamyl-epsilon-lysine bonds in Alzheimer's neurofibrillary tangles.

Nemes Z, Devreese B, Steinert PM, Van Beeumen J, Fésüs L.

FASEB J. 2004 Jul;18(10):1135-7. Epub 2004 May 7.

PMID:
15132984
9.

Proteasome-caspase-cathepsin sequence leading to tau pathology induced by prostaglandin J2 in neuronal cells.

Arnaud LT, Myeku N, Figueiredo-Pereira ME.

J Neurochem. 2009 Jul;110(1):328-42. doi: 10.1111/j.1471-4159.2009.06142.x. Epub 2009 May 3.

10.

Protein aggregation in Alzheimer's disease: Aβ and τ and their potential roles in the pathogenesis of AD.

Thal DR, Fändrich M.

Acta Neuropathol. 2015 Feb;129(2):163-5. doi: 10.1007/s00401-015-1387-2. No abstract available.

PMID:
25600324
11.

Soluble pre-fibrillar tau and β-amyloid species emerge in early human Alzheimer's disease and track disease progression and cognitive decline.

Koss DJ, Jones G, Cranston A, Gardner H, Kanaan NM, Platt B.

Acta Neuropathol. 2016 Dec;132(6):875-895. Epub 2016 Oct 21.

12.

Frameshift proteins in Alzheimer's disease and in other conformational disorders: time for the ubiquitin-proteasome system.

van Leeuwen FW, Hol EM, Fischer DF.

J Alzheimers Dis. 2006;9(3 Suppl):319-25. Review.

PMID:
16914870
14.

Amyloid-induced neurofibrillary tangle formation in Alzheimer's disease: insight from transgenic mouse and tissue-culture models.

Götz J, Schild A, Hoerndli F, Pennanen L.

Int J Dev Neurosci. 2004 Nov;22(7):453-65. Review.

PMID:
15465275
15.

The role of ubiquitin proteasomal system and autophagy-lysosome pathway in Alzheimer's disease.

Zhang Y, Chen X, Zhao Y, Ponnusamy M, Liu Y.

Rev Neurosci. 2017 Nov 27;28(8):861-868. doi: 10.1515/revneuro-2017-0013. Review.

PMID:
28704199
16.

Dissecting the role of non-coding RNAs in the accumulation of amyloid and tau neuropathologies in Alzheimer's disease.

Patrick E, Rajagopal S, Wong HA, McCabe C, Xu J, Tang A, Imboywa SH, Schneider JA, Pochet N, Krichevsky AM, Chibnik LB, Bennett DA, De Jager PL.

Mol Neurodegener. 2017 Jul 1;12(1):51. doi: 10.1186/s13024-017-0191-y.

17.

Beneficial effect of human anti-amyloid-beta active immunization on neurite morphology and tau pathology.

Serrano-Pozo A, William CM, Ferrer I, Uro-Coste E, Delisle MB, Maurage CA, Hock C, Nitsch RM, Masliah E, Growdon JH, Frosch MP, Hyman BT.

Brain. 2010 May;133(Pt 5):1312-27. doi: 10.1093/brain/awq056. Epub 2010 Mar 31.

18.

Tau-amyloid interactions in the rTgTauEC model of early Alzheimer's disease suggest amyloid-induced disruption of axonal projections and exacerbated axonal pathology.

Pooler AM, Polydoro M, Wegmann SK, Pitstick R, Kay KR, Sanchez L, Carlson GA, Gomez-Isla T, Albers MW, Spires-Jones TL, Hyman BT.

J Comp Neurol. 2013 Dec 15;521(18):4236-48. doi: 10.1002/cne.23411.

19.

The Ubiquitin-Proteasome System and Molecular Chaperone Deregulation in Alzheimer's Disease.

Sulistio YA, Heese K.

Mol Neurobiol. 2016 Mar;53(2):905-31. doi: 10.1007/s12035-014-9063-4. Epub 2015 Jan 7. Review.

PMID:
25561438
20.

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