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Items: 1 to 20 of 103

1.

A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis.

Dütting S, Gaits-Iacovoni F, Stegner D, Popp M, Antkowiak A, van Eeuwijk JMM, Nurden P, Stritt S, Heib T, Aurbach K, Angay O, Cherpokova D, Heinz N, Baig AA, Gorelashvili MG, Gerner F, Heinze KG, Ware J, Krohne G, Ruggeri ZM, Nurden AT, Schulze H, Modlich U, Pleines I, Brakebusch C, Nieswandt B.

Nat Commun. 2017 Jun 15;8:15838. doi: 10.1038/ncomms15838.

2.

Defective tubulin organization and proplatelet formation in murine megakaryocytes lacking Rac1 and Cdc42.

Pleines I, Dütting S, Cherpokova D, Eckly A, Meyer I, Morowski M, Krohne G, Schulze H, Gachet C, Debili N, Brakebusch C, Nieswandt B.

Blood. 2013 Oct 31;122(18):3178-87. doi: 10.1182/blood-2013-03-487942. Epub 2013 Jul 16.

3.

Intrinsic impaired proplatelet formation and microtubule coil assembly of megakaryocytes in a mouse model of Bernard-Soulier syndrome.

Strassel C, Eckly A, Léon C, Petitjean C, Freund M, Cazenave JP, Gachet C, Lanza F.

Haematologica. 2009 Jun;94(6):800-10. doi: 10.3324/haematol.2008.001032. Epub 2009 Apr 18.

4.

Lentiviral gene rescue of a Bernard-Soulier mouse model to study platelet glycoprotein Ibβ function.

Strassel C, Bull A, Moog S, Receveur N, Mallo L, Mangin P, Eckly A, Freund M, Dubart-Kupperschmitt A, Gachet C, Lanza F.

J Thromb Haemost. 2016 Jul;14(7):1470-9. doi: 10.1111/jth.13355. Epub 2016 Jul 14. Erratum in: J Thromb Haemost. 2017 Jan;15(1):208.

5.

Critical role for ERK1/2 in bone marrow and fetal liver-derived primary megakaryocyte differentiation, motility, and proplatelet formation.

Mazharian A, Watson SP, Séverin S.

Exp Hematol. 2009 Oct;37(10):1238-1249.e5. doi: 10.1016/j.exphem.2009.07.006. Epub 2009 Jul 18.

6.

Ultrastructural analysis of megakaryocytes in GPV knockout mice.

Poujol C, Ramakrishnan V, DeGuzman F, Nurden AT, Phillips DR, Nurden P.

Thromb Haemost. 2000 Aug;84(2):312-8.

PMID:
10959706
7.

Heat-shock protein gp96/grp94 is an essential chaperone for the platelet glycoprotein Ib-IX-V complex.

Staron M, Wu S, Hong F, Stojanovic A, Du X, Bona R, Liu B, Li Z.

Blood. 2011 Jun 30;117(26):7136-44. doi: 10.1182/blood-2011-01-330464. Epub 2011 May 16.

8.
9.

Megakaryocytes derived from patients with the classical form of Bernard-Soulier syndrome show no ability to extend proplatelets in vitro.

Balduini A, Malara A, Balduini CL, Noris P.

Platelets. 2011;22(4):308-11. doi: 10.3109/09537104.2010.547960. Epub 2011 Feb 15. No abstract available.

PMID:
21322749
10.

Generation and rescue of a murine model of platelet dysfunction: the Bernard-Soulier syndrome.

Ware J, Russell S, Ruggeri ZM.

Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2803-8.

11.

Decreased thrombotic tendency in mouse models of the Bernard-Soulier syndrome.

Strassel C, Nonne C, Eckly A, David T, Leon C, Freund M, Cazenave JP, Gachet C, Lanza F.

Arterioscler Thromb Vasc Biol. 2007 Jan;27(1):241-7. Epub 2006 Nov 9.

PMID:
17095718
12.

OP9 bone marrow stroma cells differentiate into megakaryocytes and platelets.

Matsubara Y, Ono Y, Suzuki H, Arai F, Suda T, Murata M, Ikeda Y.

PLoS One. 2013;8(3):e58123. doi: 10.1371/journal.pone.0058123. Epub 2013 Mar 1.

14.

Effect of infusing rat monoclonal antibodies to the murine GPIb-IX-V complex on platelet and megakaryocyte morphology in mice.

Poujol C, Bergmeier W, Nurden P, Nieswandt B, Nurden A.

Platelets. 2003 Feb;14(1):35-45. Erratum in: Platelets. 2003 May;14(3):200.

PMID:
12623445
15.

Genetic deletion of platelet glycoprotein Ib alpha but not its extracellular domain protects from atherosclerosis.

Koltsova EK, Sundd P, Zarpellon A, Ouyang H, Mikulski Z, Zampolli A, Ruggeri ZM, Ley K.

Thromb Haemost. 2014 Dec;112(6):1252-63. doi: 10.1160/TH14-02-0130. Epub 2014 Aug 7.

16.

Platelet demand modulates the type of intravascular protrusion of megakaryocytes in bone marrow.

Kowata S, Isogai S, Murai K, Ito S, Tohyama K, Ema M, Hitomi J, Ishida Y.

Thromb Haemost. 2014 Oct;112(4):743-56. doi: 10.1160/TH14-02-0123. Epub 2014 Jun 26.

PMID:
24965909
17.

RhoA is essential for maintaining normal megakaryocyte ploidy and platelet generation.

Suzuki A, Shin JW, Wang Y, Min SH, Poncz M, Choi JK, Discher DE, Carpenter CL, Lian L, Zhao L, Wang Y, Abrams CS.

PLoS One. 2013 Jul 23;8(7):e69315. doi: 10.1371/journal.pone.0069315. Print 2013.

18.

The regulation of proplatelet production.

Geddis AE.

Haematologica. 2009 Jun;94(6):756-9. doi: 10.3324/haematol.2009.006577. No abstract available.

19.

Surface expression of glycoprotein ib alpha is dependent on glycoprotein ib beta: evidence from a novel mutation causing Bernard-Soulier syndrome.

Moran N, Morateck PA, Deering A, Ryan M, Montgomery RR, Fitzgerald DJ, Kenny D.

Blood. 2000 Jul 15;96(2):532-9.

20.

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