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Items: 1 to 20 of 97

1.

NLRP3 signaling drives macrophage-induced adaptive immune suppression in pancreatic carcinoma.

Daley D, Mani VR, Mohan N, Akkad N, Pandian GSDB, Savadkar S, Lee KB, Torres-Hernandez A, Aykut B, Diskin B, Wang W, Farooq MS, Mahmud AI, Werba G, Morales EJ, Lall S, Wadowski BJ, Rubin AG, Berman ME, Narayanan R, Hundeyin M, Miller G.

J Exp Med. 2017 Jun 5;214(6):1711-1724. doi: 10.1084/jem.20161707. Epub 2017 Apr 25.

2.

The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression.

Seifert L, Werba G, Tiwari S, Giao Ly NN, Alothman S, Alqunaibit D, Avanzi A, Barilla R, Daley D, Greco SH, Torres-Hernandez A, Pergamo M, Ochi A, Zambirinis CP, Pansari M, Rendon M, Tippens D, Hundeyin M, Mani VR, Hajdu C, Engle D, Miller G.

Nature. 2016 Apr 14;532(7598):245-9. doi: 10.1038/nature17403. Epub 2016 Apr 6.

3.

T-cell programming in pancreatic adenocarcinoma: a review.

Seo YD, Pillarisetty VG.

Cancer Gene Ther. 2017 Mar;24(3):106-113. doi: 10.1038/cgt.2016.66. Epub 2016 Dec 2. Review.

PMID:
27910859
4.

NLRP3 Is a Critical Regulator of Inflammation and Innate Immune Cell Response during Mycoplasma pneumoniae Infection.

Segovia JA, Chang TH, Winter VT, Coalson JJ, Cagle MP, Pandranki L, Bose S, Baseman JB, Kannan TR.

Infect Immun. 2017 Dec 19;86(1). pii: e00548-17. doi: 10.1128/IAI.00548-17. Print 2018 Jan.

5.

Apoptosis-associated speck-like protein containing a CARD forms specks but does not activate caspase-1 in the absence of NLRP3 during macrophage swelling.

Compan V, Martín-Sánchez F, Baroja-Mazo A, López-Castejón G, Gomez AI, Verkhratsky A, Brough D, Pelegrín P.

J Immunol. 2015 Feb 1;194(3):1261-73. doi: 10.4049/jimmunol.1301676. Epub 2014 Dec 31.

6.

Oxidized phosphatidylcholine induces the activation of NLRP3 inflammasome in macrophages.

Yeon SH, Yang G, Lee HE, Lee JY.

J Leukoc Biol. 2017 Jan;101(1):205-215. doi: 10.1189/jlb.3VMA1215-579RR. Epub 2016 Jun 2.

PMID:
27256568
7.

TNF-α Induces Caspase-1 Activation Independently of Simultaneously Induced NLRP3 in 3T3-L1 Cells.

Furuoka M, Ozaki K, Sadatomi D, Mamiya S, Yonezawa T, Tanimura S, Takeda K.

J Cell Physiol. 2016 Dec;231(12):2761-7. doi: 10.1002/jcp.25385. Epub 2016 Mar 30.

PMID:
26989816
8.

NLRP3 regulates a non-canonical platform for caspase-8 activation during epithelial cell apoptosis.

Chung H, Vilaysane A, Lau A, Stahl M, Morampudi V, Bondzi-Simpson A, Platnich JM, Bracey NA, French MC, Beck PL, Chun J, Vallance BA, Muruve DA.

Cell Death Differ. 2016 Aug;23(8):1331-46. doi: 10.1038/cdd.2016.14. Epub 2016 Feb 19.

9.

Inhibition of NLRP3 Inflammasome Pathway by Butyrate Improves Corneal Wound Healing in Corneal Alkali Burn.

Bian F, Xiao Y, Zaheer M, Volpe EA, Pflugfelder SC, Li DQ, de Paiva CS.

Int J Mol Sci. 2017 Mar 5;18(3). pii: E562. doi: 10.3390/ijms18030562.

10.

NOD2 (Nucleotide-Binding Oligomerization Domain 2) Is a Major Pathogenic Mediator of Coxsackievirus B3-Induced Myocarditis.

Tschöpe C, Müller I, Xia Y, Savvatis K, Pappritz K, Pinkert S, Lassner D, Heimesaat MM, Spillmann F, Miteva K, Bereswill S, Schultheiss HP, Fechner H, Pieske B, Kühl U, Van Linthout S.

Circ Heart Fail. 2017 Sep;10(9). pii: e003870. doi: 10.1161/CIRCHEARTFAILURE.117.003870.

PMID:
28912259
11.

NLRP3 inflammasome signaling is activated by low-level lysosome disruption but inhibited by extensive lysosome disruption: roles for K+ efflux and Ca2+ influx.

Katsnelson MA, Lozada-Soto KM, Russo HM, Miller BA, Dubyak GR.

Am J Physiol Cell Physiol. 2016 Jul 1;311(1):C83-C100. doi: 10.1152/ajpcell.00298.2015. Epub 2016 May 11.

12.

Activation of inflammasomes in dendritic cells and macrophages by Mycoplasma salivarium.

Sugiyama M, Saeki A, Hasebe A, Kamesaki R, Yoshida Y, Kitagawa Y, Suzuki T, Shibata K.

Mol Oral Microbiol. 2016 Jun;31(3):259-69. doi: 10.1111/omi.12117. Epub 2015 Sep 4.

PMID:
26177301
13.

Inflammasome activation by mitochondrial oxidative stress in macrophages leads to the development of angiotensin II-induced aortic aneurysm.

Usui F, Shirasuna K, Kimura H, Tatsumi K, Kawashima A, Karasawa T, Yoshimura K, Aoki H, Tsutsui H, Noda T, Sagara J, Taniguchi S, Takahashi M.

Arterioscler Thromb Vasc Biol. 2015 Jan;35(1):127-36. doi: 10.1161/ATVBAHA.114.303763. Epub 2014 Nov 6.

PMID:
25378412
14.

Caspase-1 autoproteolysis is differentially required for NLRP1b and NLRP3 inflammasome function.

Guey B, Bodnar M, Manié SN, Tardivel A, Petrilli V.

Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17254-9. doi: 10.1073/pnas.1415756111. Epub 2014 Nov 17.

15.

Dectin 1 activation on macrophages by galectin 9 promotes pancreatic carcinoma and peritumoral immune tolerance.

Daley D, Mani VR, Mohan N, Akkad N, Ochi A, Heindel DW, Lee KB, Zambirinis CP, Pandian GSB, Savadkar S, Torres-Hernandez A, Nayak S, Wang D, Hundeyin M, Diskin B, Aykut B, Werba G, Barilla RM, Rodriguez R, Chang S, Gardner L, Mahal LK, Ueberheide B, Miller G.

Nat Med. 2017 May;23(5):556-567. doi: 10.1038/nm.4314. Epub 2017 Apr 10.

16.

P2X7 receptor-stimulated secretion of MHC class II-containing exosomes requires the ASC/NLRP3 inflammasome but is independent of caspase-1.

Qu Y, Ramachandra L, Mohr S, Franchi L, Harding CV, Nunez G, Dubyak GR.

J Immunol. 2009 Apr 15;182(8):5052-62. doi: 10.4049/jimmunol.0802968.

17.

Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner.

Conos SA, Chen KW, De Nardo D, Hara H, Whitehead L, Núñez G, Masters SL, Murphy JM, Schroder K, Vaux DL, Lawlor KE, Lindqvist LM, Vince JE.

Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):E961-E969. doi: 10.1073/pnas.1613305114. Epub 2017 Jan 17. Erratum in: Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):E5762-E5763.

18.

T cell-intrinsic ASC critically promotes T(H)17-mediated experimental autoimmune encephalomyelitis.

Martin BN, Wang C, Zhang CJ, Kang Z, Gulen MF, Zepp JA, Zhao J, Bian G, Do JS, Min B, Pavicic PG Jr, El-Sanadi C, Fox PL, Akitsu A, Iwakura Y, Sarkar A, Wewers MD, Kaiser WJ, Mocarski ES, Rothenberg ME, Hise AG, Dubyak GR, Ransohoff RM, Li X.

Nat Immunol. 2016 May;17(5):583-92. doi: 10.1038/ni.3389. Epub 2016 Mar 21.

19.

Metformin Reduces Desmoplasia in Pancreatic Cancer by Reprogramming Stellate Cells and Tumor-Associated Macrophages.

Incio J, Suboj P, Chin SM, Vardam-Kaur T, Liu H, Hato T, Babykutty S, Chen I, Deshpande V, Jain RK, Fukumura D.

PLoS One. 2015 Dec 7;10(12):e0141392. doi: 10.1371/journal.pone.0141392. eCollection 2015.

20.

Caspase-1/ASC inflammasome-mediated activation of IL-1β-ROS-NF-κB pathway for control of Trypanosoma cruzi replication and survival is dispensable in NLRP3-/- macrophages.

Dey N, Sinha M, Gupta S, Gonzalez MN, Fang R, Endsley JJ, Luxon BA, Garg NJ.

PLoS One. 2014 Nov 5;9(11):e111539. doi: 10.1371/journal.pone.0111539. eCollection 2014.

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