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Items: 1 to 20 of 177

1.

Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation.

Cheung KL, Zhang F, Jaganathan A, Sharma R, Zhang Q, Konuma T, Shen T, Lee JY, Ren C, Chen CH, Lu G, Olson MR, Zhang W, Kaplan MH, Littman DR, Walsh MJ, Xiong H, Zeng L, Zhou MM.

Mol Cell. 2017 Mar 16;65(6):1068-1080.e5. doi: 10.1016/j.molcel.2016.12.022. Epub 2017 Mar 3.

2.

The BET Protein BRD2 Cooperates with CTCF to Enforce Transcriptional and Architectural Boundaries.

Hsu SC, Gilgenast TG, Bartman CR, Edwards CR, Stonestrom AJ, Huang P, Emerson DJ, Evans P, Werner MT, Keller CA, Giardine B, Hardison RC, Raj A, Phillips-Cremins JE, Blobel GA.

Mol Cell. 2017 Apr 6;66(1):102-116.e7. doi: 10.1016/j.molcel.2017.02.027.

4.

A role for CTCF and cohesin in subtelomere chromatin organization, TERRA transcription, and telomere end protection.

Deng Z, Wang Z, Stong N, Plasschaert R, Moczan A, Chen HS, Hu S, Wikramasinghe P, Davuluri RV, Bartolomei MS, Riethman H, Lieberman PM.

EMBO J. 2012 Nov 5;31(21):4165-78. doi: 10.1038/emboj.2012.266. Epub 2012 Sep 25.

5.

BRD4 Couples NF-κB/RelA with Airway Inflammation and the IRF-RIG-I Amplification Loop in Respiratory Syncytial Virus Infection.

Tian B, Yang J, Zhao Y, Ivanciuc T, Sun H, Garofalo RP, Brasier AR.

J Virol. 2017 Feb 28;91(6). pii: e00007-17. doi: 10.1128/JVI.00007-17. Print 2017 Mar 15.

6.

BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment.

Winter GE, Mayer A, Buckley DL, Erb MA, Roderick JE, Vittori S, Reyes JM, di Iulio J, Souza A, Ott CJ, Roberts JM, Zeid R, Scott TG, Paulk J, Lachance K, Olson CM, Dastjerdi S, Bauer S, Lin CY, Gray NS, Kelliher MA, Churchman LS, Bradner JE.

Mol Cell. 2017 Jul 6;67(1):5-18.e19. doi: 10.1016/j.molcel.2017.06.004. Epub 2017 Jun 29.

7.

The bromodomain protein Brd4 stimulates G1 gene transcription and promotes progression to S phase.

Mochizuki K, Nishiyama A, Jang MK, Dey A, Ghosh A, Tamura T, Natsume H, Yao H, Ozato K.

J Biol Chem. 2008 Apr 4;283(14):9040-8. doi: 10.1074/jbc.M707603200. Epub 2008 Jan 27.

8.

Phosphorylation of CDK9 at Ser175 enhances HIV transcription and is a marker of activated P-TEFb in CD4(+) T lymphocytes.

Mbonye UR, Gokulrangan G, Datt M, Dobrowolski C, Cooper M, Chance MR, Karn J.

PLoS Pathog. 2013;9(5):e1003338. doi: 10.1371/journal.ppat.1003338. Epub 2013 May 2.

9.

Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells.

Zhang W, Prakash C, Sum C, Gong Y, Li Y, Kwok JJ, Thiessen N, Pettersson S, Jones SJ, Knapp S, Yang H, Chin KC.

J Biol Chem. 2012 Dec 14;287(51):43137-55. doi: 10.1074/jbc.M112.413047. Epub 2012 Oct 19.

10.

Topoisomerase II beta interacts with cohesin and CTCF at topological domain borders.

Uusküla-Reimand L, Hou H, Samavarchi-Tehrani P, Rudan MV, Liang M, Medina-Rivera A, Mohammed H, Schmidt D, Schwalie P, Young EJ, Reimand J, Hadjur S, Gingras AC, Wilson MD.

Genome Biol. 2016 Aug 31;17(1):182. doi: 10.1186/s13059-016-1043-8.

11.

BRD4 mediates NF-κB-dependent epithelial-mesenchymal transition and pulmonary fibrosis via transcriptional elongation.

Tian B, Zhao Y, Sun H, Zhang Y, Yang J, Brasier AR.

Am J Physiol Lung Cell Mol Physiol. 2016 Dec 1;311(6):L1183-L1201. doi: 10.1152/ajplung.00224.2016. Epub 2016 Oct 28.

12.

The functional role of an interleukin 6-inducible CDK9.STAT3 complex in human gamma-fibrinogen gene expression.

Hou T, Ray S, Brasier AR.

J Biol Chem. 2007 Dec 21;282(51):37091-102. Epub 2007 Oct 23.

13.

Polo-like kinase 1 inhibits the activity of positive transcription elongation factor of RNA Pol II b (P-TEFb).

Jiang L, Huang Y, Deng M, Liu T, Lai W, Ye X.

PLoS One. 2013 Aug 16;8(8):e72289. doi: 10.1371/journal.pone.0072289. eCollection 2013.

14.

BRD4 coordinates recruitment of pause release factor P-TEFb and the pausing complex NELF/DSIF to regulate transcription elongation of interferon-stimulated genes.

Patel MC, Debrosse M, Smith M, Dey A, Huynh W, Sarai N, Heightman TD, Tamura T, Ozato K.

Mol Cell Biol. 2013 Jun;33(12):2497-507. doi: 10.1128/MCB.01180-12. Epub 2013 Apr 15.

15.

CCCTC-binding factor (CTCF) and cohesin influence the genomic architecture of the Igh locus and antisense transcription in pro-B cells.

Degner SC, Verma-Gaur J, Wong TP, Bossen C, Iverson GM, Torkamani A, Vettermann C, Lin YC, Ju Z, Schulz D, Murre CS, Birshtein BK, Schork NJ, Schlissel MS, Riblet R, Murre C, Feeney AJ.

Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9566-71. doi: 10.1073/pnas.1019391108. Epub 2011 May 23.

16.

Brd4 marks select genes on mitotic chromatin and directs postmitotic transcription.

Dey A, Nishiyama A, Karpova T, McNally J, Ozato K.

Mol Biol Cell. 2009 Dec;20(23):4899-909. doi: 10.1091/mbc.E09-05-0380. Epub 2009 Oct 7.

17.

Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules.

Faure AJ, Schmidt D, Watt S, Schwalie PC, Wilson MD, Xu H, Ramsay RG, Odom DT, Flicek P.

Genome Res. 2012 Nov;22(11):2163-75. doi: 10.1101/gr.136507.111. Epub 2012 Jul 10.

18.

Gene-specific repression of the p53 target gene PUMA via intragenic CTCF-Cohesin binding.

Gomes NP, Espinosa JM.

Genes Dev. 2010 May 15;24(10):1022-34. doi: 10.1101/gad.1881010.

19.

The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription.

Jang MK, Mochizuki K, Zhou M, Jeong HS, Brady JN, Ozato K.

Mol Cell. 2005 Aug 19;19(4):523-34.

20.

Cohesin is positioned in mammalian genomes by transcription, CTCF and Wapl.

Busslinger GA, Stocsits RR, van der Lelij P, Axelsson E, Tedeschi A, Galjart N, Peters JM.

Nature. 2017 Apr 27;544(7651):503-507. doi: 10.1038/nature22063. Epub 2017 Apr 19.

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