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Redeploying β-Lactams Against Staphylococcus aureus: Repurposing With a Purpose.

Bayer AS, Xiong YQ.

J Infect Dis. 2017 Jan 1;215(1):11-13. doi: 10.1093/infdis/jiw464. Epub 2016 Nov 14. No abstract available.


Combinations of β-lactam or aminoglycoside antibiotics with plectasin are synergistic against methicillin-sensitive and methicillin-resistant Staphylococcus aureus.

Hu Y, Liu A, Vaudrey J, Vaiciunaite B, Moigboi C, McTavish SM, Kearns A, Coates A.

PLoS One. 2015 Feb 18;10(2):e0117664. doi: 10.1371/journal.pone.0117664. eCollection 2015.


Mechanism of synergy between epigallocatechin gallate and beta-lactams against methicillin-resistant Staphylococcus aureus.

Zhao WH, Hu ZQ, Okubo S, Hara Y, Shimamura T.

Antimicrob Agents Chemother. 2001 Jun;45(6):1737-42.


β-Lactams increase the antibacterial activity of daptomycin against clinical methicillin-resistant Staphylococcus aureus strains and prevent selection of daptomycin-resistant derivatives.

Mehta S, Singh C, Plata KB, Chanda PK, Paul A, Riosa S, Rosato RR, Rosato AE.

Antimicrob Agents Chemother. 2012 Dec;56(12):6192-200. doi: 10.1128/AAC.01525-12. Epub 2012 Sep 17.


Methicillin-resistant Staphylococcus aureus infections: role of daptomycin/β-lactams combination.

Leone S, Noviello S, Boccia G, De Caro F, Esposito S.

Infez Med. 2015 Jun;23(2):99-104. Review.


Low levels of β-lactam antibiotics induce extracellular DNA release and biofilm formation in Staphylococcus aureus.

Kaplan JB, Izano EA, Gopal P, Karwacki MT, Kim S, Bose JL, Bayles KW, Horswill AR.

MBio. 2012 Jul 31;3(4):e00198-12. doi: 10.1128/mBio.00198-12. Print 2012.


Staphylococcus aureus nasal carriage, virulence traits, antibiotic resistance mechanisms, and genetic lineages in healthy humans in Spain, with detection of CC398 and CC97 strains.

Lozano C, Gómez-Sanz E, Benito D, Aspiroz C, Zarazaga M, Torres C.

Int J Med Microbiol. 2011 Aug;301(6):500-5. doi: 10.1016/j.ijmm.2011.02.004. Epub 2011 May 12.


Combinations of cefoxitin plus other β-lactams are synergistic in vitro against community associated methicillin-resistant Staphylococcus aureus.

Banerjee R, Fernandez MG, Enthaler N, Graml C, Greenwood-Quaintance KE, Patel R.

Eur J Clin Microbiol Infect Dis. 2013 Jun;32(6):827-33. doi: 10.1007/s10096-013-1817-9. Epub 2013 Jan 23.


Oritavancin Combinations with β-Lactams against Multidrug-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococci.

Smith JR, Yim J, Raut A, Rybak MJ.

Antimicrob Agents Chemother. 2016 Mar 25;60(4):2352-8. doi: 10.1128/AAC.03006-15. Print 2016 Apr.


Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.

Lemaire S, Olivier A, Van Bambeke F, Tulkens PM, Appelbaum PC, Glupczynski Y.

Antimicrob Agents Chemother. 2008 Aug;52(8):2797-805. doi: 10.1128/AAC.00123-08. Epub 2008 Jun 2.


Panton-Valentine leukocidin (PVL)-positive methicillin-susceptible and resistant Staphylococcus aureus in Taiwan: identification of oxacillin-susceptible mecA-positive methicillin-resistant S. aureus.

Chen FJ, Hiramatsu K, Huang IW, Wang CH, Lauderdale TL.

Diagn Microbiol Infect Dis. 2009 Dec;65(4):351-7. doi: 10.1016/j.diagmicrobio.2009.07.024. Epub 2009 Sep 19.


Synergistic Anti-bacterial Effects of Phellinus baumii Ethyl Acetate Extracts and β-Lactam Antimicrobial Agents Against Methicillin-Resistant Staphylococcus aureus.

Hong SB, Rhee MH, Yun BS, Lim YH, Song HG, Shin KS.

Ann Lab Med. 2016 Mar;36(2):111-6. doi: 10.3343/alm.2016.36.2.111.


N-thiolated beta-lactams: novel antibacterial agents for methicillin-resistant Staphylococcus aureus.

Turos E, Long TE, Konaklieva MI, Coates C, Shim JY, Dickey S, Lim DV, Cannons A.

Bioorg Med Chem Lett. 2002 Aug 19;12(16):2229-31.


Phenotypic and genotypic characterization of methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-susceptible Staphylococcus aureus (MSSA) from different sources in China.

Chao G, Zhang X, Zhang X, Huang Y, Xu L, Zhou L, Yang W, Jiang Y, Xue F, Wu Y.

Foodborne Pathog Dis. 2013 Mar;10(3):214-21. doi: 10.1089/fpd.2012.1205. Epub 2013 Feb 13.


Natural lipopeptide antibiotic tripropeptin C revitalizes and synergistically potentiates the activity of beta-lactams against methicillin-resistant Staphylococcus aureus.

Hashizume H, Takahashi Y, Harada S, Nomoto A.

J Antibiot (Tokyo). 2015 Jun;68(6):373-8. doi: 10.1038/ja.2014.169. Epub 2015 Jan 14.


Comparative activities of telavancin combined with nafcillin, imipenem, and gentamicin against Staphylococcus aureus.

Leonard SN, Supple ME, Gandhi RG, Patel MD.

Antimicrob Agents Chemother. 2013 Jun;57(6):2678-83. doi: 10.1128/AAC.02127-12. Epub 2013 Apr 1.


PBP 4 Mediates High-Level Resistance to New-Generation Cephalosporins in Staphylococcus aureus.

Chan LC, Gilbert A, Basuino L, da Costa TM, Hamilton SM, Dos Santos KR, Chambers HF, Chatterjee SS.

Antimicrob Agents Chemother. 2016 Jun 20;60(7):3934-41. doi: 10.1128/AAC.00358-16. Print 2016 Jul.


Multidrug-resistant clones of community-associated meticillin-resistant Staphylococcus aureus isolated from Chinese children and the resistance genes to clindamycin and mupirocin.

Wang L, Liu Y, Yang Y, Huang G, Wang C, Deng L, Zheng Y, Fu Z, Li C, Shang Y, Zhao C, Sun M, Li X, Yu S, Yao K, Shen X.

J Med Microbiol. 2012 Sep;61(Pt 9):1240-7. doi: 10.1099/jmm.0.042663-0. Epub 2012 May 17.


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