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Items: 1 to 20 of 95

1.

Charge-altering releasable transporters (CARTs) for the delivery and release of mRNA in living animals.

McKinlay CJ, Vargas JR, Blake TR, Hardy JW, Kanada M, Contag CH, Wender PA, Waymouth RM.

Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):E448-E456. doi: 10.1073/pnas.1614193114. Epub 2017 Jan 9.

2.

Enhanced mRNA delivery into lymphocytes enabled by lipid-varied libraries of charge-altering releasable transporters.

McKinlay CJ, Benner NL, Haabeth OA, Waymouth RM, Wender PA.

Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):E5859-E5866. doi: 10.1073/pnas.1805358115. Epub 2018 Jun 11.

3.

Functional DNA Delivery Enabled by Lipid-Modified Charge-Altering Releasable Transporters (CARTs).

Benner NL, Near KE, Bachmann MH, Contag CH, Waymouth RM, Wender PA.

Biomacromolecules. 2018 Jul 9;19(7):2812-2824. doi: 10.1021/acs.biomac.8b00401. Epub 2018 May 11.

PMID:
29727572
4.

Biomaterials for mRNA delivery.

Islam MA, Reesor EK, Xu Y, Zope HR, Zetter BR, Shi J.

Biomater Sci. 2015 Dec;3(12):1519-33. doi: 10.1039/c5bm00198f. Epub 2015 Aug 17.

5.

Boosting Intracellular Delivery of Lipid Nanoparticle-Encapsulated mRNA.

Patel S, Ashwanikumar N, Robinson E, DuRoss A, Sun C, Murphy-Benenato KE, Mihai C, Almarsson Ö, Sahay G.

Nano Lett. 2017 Sep 13;17(9):5711-5718. doi: 10.1021/acs.nanolett.7b02664. Epub 2017 Aug 24.

6.

Gene gun delivery of mRNA in situ results in efficient transgene expression and genetic immunization.

Qiu P, Ziegelhoffer P, Sun J, Yang NS.

Gene Ther. 1996 Mar;3(3):262-8.

PMID:
8646558
7.

Biodegradable Amino-Ester Nanomaterials for Cas9 mRNA Delivery in Vitro and in Vivo.

Zhang X, Li B, Luo X, Zhao W, Jiang J, Zhang C, Gao M, Chen X, Dong Y.

ACS Appl Mater Interfaces. 2017 Aug 2;9(30):25481-25487. doi: 10.1021/acsami.7b08163. Epub 2017 Jul 19.

8.

Messenger RNA-based therapeutics for brain diseases: An animal study for augmenting clearance of beta-amyloid by intracerebral administration of neprilysin mRNA loaded in polyplex nanomicelles.

Lin CY, Perche F, Ikegami M, Uchida S, Kataoka K, Itaka K.

J Control Release. 2016 Aug 10;235:268-275. doi: 10.1016/j.jconrel.2016.06.001. Epub 2016 Jun 6.

PMID:
27282413
9.

Inhibition of Xenograft tumor growth by gold nanoparticle-DNA oligonucleotide conjugates-assisted delivery of BAX mRNA.

Yeom JH, Ryou SM, Won M, Park M, Bae J, Lee K.

PLoS One. 2013 Sep 20;8(9):e75369. doi: 10.1371/journal.pone.0075369. eCollection 2013.

10.

The use of biodegradable PLGA nanoparticles to mediate SOX9 gene delivery in human mesenchymal stem cells (hMSCs) and induce chondrogenesis.

Kim JH, Park JS, Yang HN, Woo DG, Jeon SY, Do HJ, Lim HY, Kim JM, Park KH.

Biomaterials. 2011 Jan;32(1):268-78. doi: 10.1016/j.biomaterials.2010.08.086. Epub 2010 Sep 27.

PMID:
20875683
11.

Characterizing exogenous mRNA delivery, trafficking, cytoplasmic release and RNA-protein correlations at the level of single cells.

Kirschman JL, Bhosle S, Vanover D, Blanchard EL, Loomis KH, Zurla C, Murray K, Lam BC, Santangelo PJ.

Nucleic Acids Res. 2017 Jul 7;45(12):e113. doi: 10.1093/nar/gkx290.

12.

Lipid Nanoparticle Packaging Is an Effective and Nontoxic mRNA Delivery Platform in Embryonic Zebrafish.

Patton C, Farr GH 3rd, An D, Martini PGV, Maves L.

Zebrafish. 2018 Jun;15(3):217-227. doi: 10.1089/zeb.2017.1511. Epub 2018 Jan 25.

PMID:
29369745
13.

Systemic mRNA Delivery to the Lungs by Functional Polyester-based Carriers.

Yan Y, Xiong H, Zhang X, Cheng Q, Siegwart DJ.

Biomacromolecules. 2017 Dec 11;18(12):4307-4315. doi: 10.1021/acs.biomac.7b01356. Epub 2017 Nov 27.

PMID:
29141136
14.

Non-Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co-Delivery of Cas9 mRNA and sgRNA.

Miller JB, Zhang S, Kos P, Xiong H, Zhou K, Perelman SS, Zhu H, Siegwart DJ.

Angew Chem Int Ed Engl. 2017 Jan 19;56(4):1059-1063. doi: 10.1002/anie.201610209. Epub 2016 Dec 16.

15.

Recent advances on biocompatible and biodegradable nanoparticles as gene carriers.

Mokhtarzadeh A, Alibakhshi A, Yaghoobi H, Hashemi M, Hejazi M, Ramezani M.

Expert Opin Biol Ther. 2016 Jun;16(6):771-85. doi: 10.1517/14712598.2016.1169269. Epub 2016 Apr 4. Review.

PMID:
26998622
16.

Materials for non-viral intracellular delivery of messenger RNA therapeutics.

Kauffman KJ, Webber MJ, Anderson DG.

J Control Release. 2016 Oct 28;240:227-234. doi: 10.1016/j.jconrel.2015.12.032. Epub 2015 Dec 21. Review.

PMID:
26718856
17.

In vivo messenger RNA introduction into the central nervous system using polyplex nanomicelle.

Uchida S, Itaka K, Uchida H, Hayakawa K, Ogata T, Ishii T, Fukushima S, Osada K, Kataoka K.

PLoS One. 2013;8(2):e56220. doi: 10.1371/journal.pone.0056220. Epub 2013 Feb 13.

18.

Polymers for nucleic acid transfer-an overview.

Wagner E.

Adv Genet. 2014;88:231-61. doi: 10.1016/B978-0-12-800148-6.00008-0. Review.

PMID:
25409608
19.

Effective gene delivery into human stem cells with a cell-targeting Peptide-modified bioreducible polymer.

Beloor J, Ramakrishna S, Nam K, Seon Choi C, Kim J, Kim SH, Cho HJ, Shin H, Kim H, Kim SW, Lee SK, Kumar P.

Small. 2015 May 6;11(17):2069-79. doi: 10.1002/smll.201402933. Epub 2014 Dec 16.

PMID:
25515928
20.

Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs.

Kauffman KJ, Dorkin JR, Yang JH, Heartlein MW, DeRosa F, Mir FF, Fenton OS, Anderson DG.

Nano Lett. 2015 Nov 11;15(11):7300-6. doi: 10.1021/acs.nanolett.5b02497. Epub 2015 Oct 20.

PMID:
26469188

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