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Deferoxamine Suppresses Collagen Cleavage and Protease, Cytokine, and COL10A1 Expression and Upregulates AMPK and Krebs Cycle Genes in Human Osteoarthritic Cartilage.

Tchetina EV, Markova GA, Poole AR, Zukor DJ, Antoniou J, Makarov SA, Kuzin AN.

Int J Rheumatol. 2016;2016:6432867. doi: 10.1155/2016/6432867. Epub 2016 Nov 30.


Activation of Indian hedgehog promotes chondrocyte hypertrophy and upregulation of MMP-13 in human osteoarthritic cartilage.

Wei F, Zhou J, Wei X, Zhang J, Fleming BC, Terek R, Pei M, Chen Q, Liu T, Wei L.

Osteoarthritis Cartilage. 2012 Jul;20(7):755-63. doi: 10.1016/j.joca.2012.03.010. Epub 2012 Mar 30.


Selective enhancement of collagenase-mediated cleavage of resident type II collagen in cultured osteoarthritic cartilage and arrest with a synthetic inhibitor that spares collagenase 1 (matrix metalloproteinase 1).

Dahlberg L, Billinghurst RC, Manner P, Nelson F, Webb G, Ionescu M, Reiner A, Tanzer M, Zukor D, Chen J, van Wart HE, Poole AR.

Arthritis Rheum. 2000 Mar;43(3):673-82.


Peptides of type II collagen can induce the cleavage of type II collagen and aggrecan in articular cartilage.

Yasuda T, Tchetina E, Ohsawa K, Roughley PJ, Wu W, Mousa A, Ionescu M, Pidoux I, Poole AR.

Matrix Biol. 2006 Sep;25(7):419-29. Epub 2006 Jun 30.


Role of interleukin-1 and tumor necrosis factor alpha in matrix degradation of human osteoarthritic cartilage.

Kobayashi M, Squires GR, Mousa A, Tanzer M, Zukor DJ, Antoniou J, Feige U, Poole AR.

Arthritis Rheum. 2005 Jan;52(1):128-35.


Gene expression in human chondrocytes in late osteoarthritis is changed in both fibrillated and intact cartilage without evidence of generalised chondrocyte hypertrophy.

Brew CJ, Clegg PD, Boot-Handford RP, Andrew JG, Hardingham T.

Ann Rheum Dis. 2010 Jan;69(1):234-40. doi: 10.1136/ard.2008.097139.


Activation of matrix metalloproteinases 2, 9, and 13 by activated protein C in human osteoarthritic cartilage chondrocytes.

Jackson MT, Moradi B, Smith MM, Jackson CJ, Little CB.

Arthritis Rheumatol. 2014 Jun;66(6):1525-36. doi: 10.1002/art.38401.


Effect of a Herbal-Leucine mix on the IL-1β-induced cartilage degradation and inflammatory gene expression in human chondrocytes.

Akhtar N, Miller MJ, Haqqi TM.

BMC Complement Altern Med. 2011 Aug 19;11:66. doi: 10.1186/1472-6882-11-66.


Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage.

Billinghurst RC, Dahlberg L, Ionescu M, Reiner A, Bourne R, Rorabeck C, Mitchell P, Hambor J, Diekmann O, Tschesche H, Chen J, Van Wart H, Poole AR.

J Clin Invest. 1997 Apr 1;99(7):1534-45.


Cytokine and catabolic enzyme expression in synovium, synovial fluid and articular cartilage of naturally osteoarthritic equine carpi.

Kamm JL, Nixon AJ, Witte TH.

Equine Vet J. 2010 Nov;42(8):693-9. doi: 10.1111/j.2042-3306.2010.00140.x. Epub 2010 Sep 14.


Overexpression of hsa-miR-148a promotes cartilage production and inhibits cartilage degradation by osteoarthritic chondrocytes.

Vonk LA, Kragten AH, Dhert WJ, Saris DB, Creemers LB.

Osteoarthritis Cartilage. 2014 Jan;22(1):145-53. doi: 10.1016/j.joca.2013.11.006. Epub 2013 Nov 21.

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