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Items: 1 to 20 of 135

1.

Reducing RBM20 activity improves diastolic dysfunction and cardiac atrophy.

Hinze F, Dieterich C, Radke MH, Granzier H, Gotthardt M.

J Mol Med (Berl). 2016 Dec;94(12):1349-1358. Epub 2016 Nov 26.

2.
3.

Alternative Splicing of Titin Restores Diastolic Function in an HFpEF-Like Genetic Murine Model (TtnΔIAjxn).

Bull M, Methawasin M, Strom J, Nair P, Hutchinson K, Granzier H.

Circ Res. 2016 Sep 2;119(6):764-72. doi: 10.1161/CIRCRESAHA.116.308904. Epub 2016 Jul 28.

4.

Increased myocardial stiffness due to cardiac titin isoform switching in a mouse model of volume overload limits eccentric remodeling.

Hutchinson KR, Saripalli C, Chung CS, Granzier H.

J Mol Cell Cardiol. 2015 Feb;79:104-14. doi: 10.1016/j.yjmcc.2014.10.020. Epub 2014 Nov 8.

5.

Truncation of titin's elastic PEVK region leads to cardiomyopathy with diastolic dysfunction.

Granzier HL, Radke MH, Peng J, Westermann D, Nelson OL, Rost K, King NM, Yu Q, Tschöpe C, McNabb M, Larson DF, Labeit S, Gotthardt M.

Circ Res. 2009 Sep 11;105(6):557-64. doi: 10.1161/CIRCRESAHA.109.200964. Epub 2009 Aug 13.

6.

Targeted deletion of titin N2B region leads to diastolic dysfunction and cardiac atrophy.

Radke MH, Peng J, Wu Y, McNabb M, Nelson OL, Granzier H, Gotthardt M.

Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3444-9. Epub 2007 Feb 20.

7.

Deranged myofilament phosphorylation and function in experimental heart failure with preserved ejection fraction.

Hamdani N, Bishu KG, von Frieling-Salewsky M, Redfield MM, Linke WA.

Cardiovasc Res. 2013 Mar 1;97(3):464-71. doi: 10.1093/cvr/cvs353. Epub 2012 Dec 4.

PMID:
23213108
8.

A novel mechanism involving four-and-a-half LIM domain protein-1 and extracellular signal-regulated kinase-2 regulates titin phosphorylation and mechanics.

Raskin A, Lange S, Banares K, Lyon RC, Zieseniss A, Lee LK, Yamazaki KG, Granzier HL, Gregorio CC, McCulloch AD, Omens JH, Sheikh F.

J Biol Chem. 2012 Aug 24;287(35):29273-84. doi: 10.1074/jbc.M112.372839. Epub 2012 Jul 9.

9.

Changes in titin and collagen underlie diastolic stiffness diversity of cardiac muscle.

Wu Y, Cazorla O, Labeit D, Labeit S, Granzier H.

J Mol Cell Cardiol. 2000 Dec;32(12):2151-62.

PMID:
11112991
10.

Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy.

Nagueh SF, Shah G, Wu Y, Torre-Amione G, King NM, Lahmers S, Witt CC, Becker K, Labeit S, Granzier HL.

Circulation. 2004 Jul 13;110(2):155-62. Epub 2004 Jul 6.

PMID:
15238456
11.

RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing.

Guo W, Schafer S, Greaser ML, Radke MH, Liss M, Govindarajan T, Maatz H, Schulz H, Li S, Parrish AM, Dauksaite V, Vakeel P, Klaassen S, Gerull B, Thierfelder L, Regitz-Zagrosek V, Hacker TA, Saupe KW, Dec GW, Ellinor PT, MacRae CA, Spallek B, Fischer R, Perrot A, Özcelik C, Saar K, Hubner N, Gotthardt M.

Nat Med. 2012 May;18(5):766-73. doi: 10.1038/nm.2693.

12.

The C-terminus of the long AKAP13 isoform (AKAP-Lbc) is critical for development of compensatory cardiac hypertrophy.

Taglieri DM, Johnson KR, Burmeister BT, Monasky MM, Spindler MJ, DeSantiago J, Banach K, Conklin BR, Carnegie GK.

J Mol Cell Cardiol. 2014 Jan;66:27-40. doi: 10.1016/j.yjmcc.2013.10.010. Epub 2013 Oct 23.

13.

Myocardial stiffness in patients with heart failure and a preserved ejection fraction: contributions of collagen and titin.

Zile MR, Baicu CF, Ikonomidis JS, Stroud RE, Nietert PJ, Bradshaw AD, Slater R, Palmer BM, Van Buren P, Meyer M, Redfield MM, Bull DA, Granzier HL, LeWinter MM.

Circulation. 2015 Apr 7;131(14):1247-59. doi: 10.1161/CIRCULATIONAHA.114.013215. Epub 2015 Jan 30.

14.

Experimentally increasing titin compliance in a novel mouse model attenuates the Frank-Starling mechanism but has a beneficial effect on diastole.

Methawasin M, Hutchinson KR, Lee EJ, Smith JE 3rd, Saripalli C, Hidalgo CG, Ottenheijm CA, Granzier H.

Circulation. 2014 May 13;129(19):1924-36. doi: 10.1161/CIRCULATIONAHA.113.005610. Epub 2014 Mar 5.

15.

Insulin regulates titin pre-mRNA splicing through the PI3K-Akt-mTOR kinase axis in a RBM20-dependent manner.

Zhu C, Yin Z, Tan B, Guo W.

Biochim Biophys Acta Mol Basis Dis. 2017 Sep;1863(9):2363-2371. doi: 10.1016/j.bbadis.2017.06.023. Epub 2017 Jul 1.

16.

Heart failure with preserved ejection fraction: chronic low-intensity interval exercise training preserves myocardial O2 balance and diastolic function.

Marshall KD, Muller BN, Krenz M, Hanft LM, McDonald KS, Dellsperger KC, Emter CA.

J Appl Physiol (1985). 2013 Jan 1;114(1):131-47. doi: 10.1152/japplphysiol.01059.2012. Epub 2012 Oct 25.

17.

Heart rate reduction by If-inhibition improves vascular stiffness and left ventricular systolic and diastolic function in a mouse model of heart failure with preserved ejection fraction.

Reil JC, Hohl M, Reil GH, Granzier HL, Kratz MT, Kazakov A, Fries P, Müller A, Lenski M, Custodis F, Gräber S, Fröhlig G, Steendijk P, Neuberger HR, Böhm M.

Eur Heart J. 2013 Sep;34(36):2839-49. doi: 10.1093/eurheartj/ehs218. Epub 2012 Jul 24.

18.

Removal of immunoglobulin-like domains from titin's spring segment alters titin splicing in mouse skeletal muscle and causes myopathy.

Buck D, Smith JE 3rd, Chung CS, Ono Y, Sorimachi H, Labeit S, Granzier HL.

J Gen Physiol. 2014 Feb;143(2):215-30. doi: 10.1085/jgp.201311129.

19.

Rbm20 regulates titin alternative splicing as a splicing repressor.

Li S, Guo W, Dewey CN, Greaser ML.

Nucleic Acids Res. 2013 Feb 1;41(4):2659-72. doi: 10.1093/nar/gks1362. Epub 2013 Jan 9.

20.

Titin isoform switching is a major cardiac adaptive response in hibernating grizzly bears.

Nelson OL, Robbins CT, Wu Y, Granzier H.

Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H366-71. doi: 10.1152/ajpheart.00234.2008. Epub 2008 May 23.

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