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Items: 1 to 20 of 298

1.

The Effect of a Novel Highly Selective Inhibitor of the Sodium/Calcium Exchanger (NCX) on Cardiac Arrhythmias in In Vitro and In Vivo Experiments.

Kohajda Z, Farkas-Morvay N, Jost N, Nagy N, Geramipour A, Horváth A, Varga RS, Hornyik T, Corici C, Acsai K, Horváth B, Prorok J, Ördög B, Déri S, Tóth D, Levijoki J, Pollesello P, Koskelainen T, Otsomaa L, Tóth A, Baczkó I, Leprán I, Nánási PP, Papp JG, Varró A, Virág L.

PLoS One. 2016 Nov 10;11(11):e0166041. doi: 10.1371/journal.pone.0166041. eCollection 2016.

2.

ORM-10103, a novel specific inhibitor of the Na+/Ca2+ exchanger, decreases early and delayed afterdepolarizations in the canine heart.

Jost N, Nagy N, Corici C, Kohajda Z, Horváth A, Acsai K, Biliczki P, Levijoki J, Pollesello P, Koskelainen T, Otsomaa L, Tóth A, Papp JG, Varró A, Virág L.

Br J Pharmacol. 2013 Oct;170(4):768-78. doi: 10.1111/bph.12228.

3.

Comparison of the efficiency of Na+/Ca2+ exchanger or Na+/H+ exchanger inhibition and their combination in reducing coronary reperfusion-induced arrhythmias.

Szepesi J, Acsai K, Sebok Z, Prorok J, Pollesello P, Levijoki J, Papp JG, Varro A, Toth A.

J Physiol Pharmacol. 2015 Apr;66(2):215-26.

4.

Nicorandil stimulates a Na⁺/Ca²⁺ exchanger by activating guanylate cyclase in guinea pig cardiac myocytes.

Wei J, Watanabe Y, Takeuchi K, Yamashita K, Tashiro M, Kita S, Iwamoto T, Watanabe H, Kimura J.

Pflugers Arch. 2016 Apr;468(4):693-703. doi: 10.1007/s00424-015-1763-8. Epub 2015 Dec 3.

PMID:
26631169
5.

Combined Na(+)/Ca(2+) exchanger and L-type calcium channel block as a potential strategy to suppress arrhythmias and maintain ventricular function.

Bourgonje VJ, Vos MA, Ozdemir S, Doisne N, Acsai K, Varro A, Sztojkov-Ivanov A, Zupko I, Rauch E, Kattner L, Bito V, Houtman M, van der Nagel R, Beekman JD, van Veen TA, Sipido KR, Antoons G.

Circ Arrhythm Electrophysiol. 2013 Apr;6(2):371-9. doi: 10.1161/CIRCEP.113.000322. Epub 2013 Mar 20.

PMID:
23515266
6.

Dofetilide enhances the contractility of rat ventricular myocytes via augmentation of Na+-Ca 2+ exchange.

Zhang XP, Wu BW, Yang CH, Wang J, Niu SC, Zhang MS.

Cardiovasc Drugs Ther. 2009 Jun;23(3):207-14. doi: 10.1007/s10557-009-6163-x. Epub 2009 Feb 17.

PMID:
19221884
7.

Inotropic effect of NCX inhibition depends on the relative activity of the reverse NCX assessed by a novel inhibitor ORM-10962 on canine ventricular myocytes.

Oravecz K, Kormos A, Gruber A, Márton Z, Kohajda Z, Mirzaei L, Jost N, Levijoki J, Pollesello P, Koskelainen T, Otsomaa L, Tóth A, Papp JG, Nánási PP, Antoons G, Varró A, Acsai K, Nagy N.

Eur J Pharmacol. 2018 Jan 5;818:278-286. doi: 10.1016/j.ejphar.2017.10.039. Epub 2017 Oct 21.

PMID:
29066415
8.

Inhibitory effect of YM-244769, a novel Na+/Ca2+ exchanger inhibitor on Na+/Ca2+ exchange current in guinea pig cardiac ventricular myocytes.

Yamashita K, Watanabe Y, Kita S, Iwamoto T, Kimura J.

Naunyn Schmiedebergs Arch Pharmacol. 2016 Nov;389(11):1205-1214. Epub 2016 Aug 1.

PMID:
27480939
9.

Selective Na(+) /Ca(2+) exchanger inhibition prevents Ca(2+) overload-induced triggered arrhythmias.

Nagy N, Kormos A, Kohajda Z, Szebeni Á, Szepesi J, Pollesello P, Levijoki J, Acsai K, Virág L, Nánási PP, Papp JG, Varró A, Tóth A.

Br J Pharmacol. 2014 Dec;171(24):5665-81. doi: 10.1111/bph.12867.

10.

Characterization of SN-6, a novel Na+/Ca2+ exchange inhibitor in guinea pig cardiac ventricular myocytes.

Niu CF, Watanabe Y, Ono K, Iwamoto T, Yamashita K, Satoh H, Urushida T, Hayashi H, Kimura J.

Eur J Pharmacol. 2007 Nov 14;573(1-3):161-9. Epub 2007 Jun 29.

PMID:
17644086
11.

The investigation of the cellular electrophysiological and antiarrhythmic effects of a novel selective sodium-calcium exchanger inhibitor, GYKB-6635, in canine and guinea-pig hearts.

Geramipour A, Kohajda Z, Corici C, Prorok J, Szakonyi Z, Oravecz K, Márton Z, Nagy N, Tóth A, Acsai K, Virág L, Varró A, Jost N.

Can J Physiol Pharmacol. 2016 Oct;94(10):1090-1101. Epub 2016 Jul 1.

PMID:
27508313
12.

Role of sodium-calcium exchanger in modulating the action potential of ventricular myocytes from normal and failing hearts.

Armoundas AA, Hobai IA, Tomaselli GF, Winslow RL, O'Rourke B.

Circ Res. 2003 Jul 11;93(1):46-53. Epub 2003 Jun 12.

13.

ORM-10103: a significant advance in sodium-calcium exchanger pharmacology?

Terracciano CM, Hancox JC.

Br J Pharmacol. 2013 Oct;170(4):765-7. doi: 10.1111/bph.12299.

14.

SEA0400, a novel Na+/Ca2+ exchanger inhibitor, reduces calcium overload induced by ischemia and reperfusion in mouse ventricular myocytes.

Wang J, Zhang Z, Hu Y, Hou X, Cui Q, Zang Y, Wang C.

Physiol Res. 2007;56(1):17-23. Epub 2006 Feb 23.

15.

Efficacy of selective NCX inhibition by ORM-10103 during simulated ischemia/reperfusion.

Kormos A, Nagy N, Acsai K, Váczi K, Ágoston S, Pollesello P, Levijoki J, Szentandrássy N, Papp JG, Varró A, Tóth A.

Eur J Pharmacol. 2014 Oct 5;740:539-51. doi: 10.1016/j.ejphar.2014.06.033. Epub 2014 Jun 27.

PMID:
24975099
16.

Discovery of N-(3,5-bis(1-pyrrolidylmethyl)-4-hydroxybenzyl)-4-methoxybenzenesulfamide (sulcardine) as a novel anti-arrhythmic agent.

Bai DL, Chen WZ, Bo YX, Dong YL, Kang AL, Sun WK, Wang W, Hu ZL, Wang YP.

Acta Pharmacol Sin. 2012 Sep;33(9):1176-86. doi: 10.1038/aps.2012.119. Epub 2012 Aug 27.

17.
18.

Inhibitory effect of aprindine on Na+/Ca2+ exchange current in guinea-pig cardiac ventricular myocytes.

Watanabe Y, Iwamoto T, Shigekawa M, Kimura J.

Br J Pharmacol. 2002 Jun;136(3):361-6.

19.
20.

Inhibition of Na+/Ca2+ exchange by KB-R7943: transport mode selectivity and antiarrhythmic consequences.

Elias CL, Lukas A, Shurraw S, Scott J, Omelchenko A, Gross GJ, Hnatowich M, Hryshko LV.

Am J Physiol Heart Circ Physiol. 2001 Sep;281(3):H1334-45.

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