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Sphingolipid biosynthesis upregulation by TOR complex 2-Ypk1 signaling during yeast adaptive response to acetic acid stress.

Guerreiro JF, Muir A, Ramachandran S, Thorner J, Sá-Correia I.

Biochem J. 2016 Dec 1;473(23):4311-4325. Epub 2016 Sep 26.


TORC2-dependent protein kinase Ypk1 phosphorylates ceramide synthase to stimulate synthesis of complex sphingolipids.

Muir A, Ramachandran S, Roelants FM, Timmons G, Thorner J.

Elife. 2014 Oct 3;3. doi: 10.7554/eLife.03779.


Plasma membrane proteins Slm1 and Slm2 mediate activation of the AGC kinase Ypk1 by TORC2 and sphingolipids in S. cerevisiae.

Niles BJ, Powers T.

Cell Cycle. 2012 Oct 15;11(20):3745-9. doi: 10.4161/cc.21752. Epub 2012 Aug 16.


TOR complex 2-Ypk1 signaling regulates actin polarization via reactive oxygen species.

Niles BJ, Powers T.

Mol Biol Cell. 2014 Dec 1;25(24):3962-72. doi: 10.1091/mbc.E14-06-1122. Epub 2014 Sep 24.


Target of rapamycin complex 2-dependent phosphorylation of the coat protein Pan1 by Akl1 controls endocytosis dynamics in Saccharomyces cerevisiae.

Bourgoint C, Rispal D, Berti M, Filipuzzi I, Helliwell SB, Prouteau M, Loewith R.

J Biol Chem. 2018 Aug 3;293(31):12043-12053. doi: 10.1074/jbc.RA117.001615. Epub 2018 Jun 12.


TOR complex 2-Ypk1 signaling maintains sphingolipid homeostasis by sensing and regulating ROS accumulation.

Niles BJ, Joslin AC, Fresques T, Powers T.

Cell Rep. 2014 Feb 13;6(3):541-52. doi: 10.1016/j.celrep.2013.12.040. Epub 2014 Jan 23. Erratum in: Cell Rep. 2014 Feb 13;6(3):592.


Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae.

Roelants FM, Breslow DK, Muir A, Weissman JS, Thorner J.

Proc Natl Acad Sci U S A. 2011 Nov 29;108(48):19222-7. doi: 10.1073/pnas.1116948108. Epub 2011 Nov 11.


Phosphorylation by the stress-activated MAPK Slt2 down-regulates the yeast TOR complex 2.

Leskoske KL, Roelants FM, Emmerstorfer-Augustin A, Augustin CM, Si EP, Hill JM, Thorner J.

Genes Dev. 2018 Dec 1;32(23-24):1576-1590. doi: 10.1101/gad.318709.118. Epub 2018 Nov 26.


TOR Complex 2-Regulated Protein Kinase Fpk1 Stimulates Endocytosis via Inhibition of Ark1/Prk1-Related Protein Kinase Akl1 in Saccharomyces cerevisiae.

Roelants FM, Leskoske KL, Pedersen RTA, Muir A, Liu JM, Finnigan GC, Thorner J.

Mol Cell Biol. 2017 Mar 17;37(7). pii: e00627-16. doi: 10.1128/MCB.00627-16. Print 2017 Apr 1.


The Stress-Sensing TORC2 Complex Activates Yeast AGC-Family Protein Kinase Ypk1 at Multiple Novel Sites.

Leskoske KL, Roelants FM, Marshall MNM, Hill JM, Thorner J.

Genetics. 2017 Sep;207(1):179-195. doi: 10.1534/genetics.117.1124. Epub 2017 Jul 24.


TOR complex 2-Ypk1 signaling is an essential positive regulator of the general amino acid control response and autophagy.

Vlahakis A, Graef M, Nunnari J, Powers T.

Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10586-91. doi: 10.1073/pnas.1406305111. Epub 2014 Jul 7.


A role for TOR complex 2 signaling in promoting autophagy.

Vlahakis A, Powers T.

Autophagy. 2014;10(11):2085-6. doi: 10.4161/auto.36262.


Orm protein phosphoregulation mediates transient sphingolipid biosynthesis response to heat stress via the Pkh-Ypk and Cdc55-PP2A pathways.

Sun Y, Miao Y, Yamane Y, Zhang C, Shokat KM, Takematsu H, Kozutsumi Y, Drubin DG.

Mol Biol Cell. 2012 Jun;23(12):2388-98. doi: 10.1091/mbc.E12-03-0209. Epub 2012 Apr 25.


Down-regulation of TORC2-Ypk1 signaling promotes MAPK-independent survival under hyperosmotic stress.

Muir A, Roelants FM, Timmons G, Leskoske KL, Thorner J.

Elife. 2015 Aug 14;4. doi: 10.7554/eLife.09336.


Sli2 (Ypk1), a homologue of mammalian protein kinase SGK, is a downstream kinase in the sphingolipid-mediated signaling pathway of yeast.

Sun Y, Taniguchi R, Tanoue D, Yamaji T, Takematsu H, Mori K, Fujita T, Kawasaki T, Kozutsumi Y.

Mol Cell Biol. 2000 Jun;20(12):4411-9.


Loss of Ypk1, the yeast homolog to the human serum- and glucocorticoid-induced protein kinase, accelerates phospholipase B1-mediated phosphatidylcholine deacylation.

Surlow BA, Cooley BM, Needham PG, Brodsky JL, Patton-Vogt J.

J Biol Chem. 2014 Nov 7;289(45):31591-604. doi: 10.1074/jbc.M114.581157. Epub 2014 Sep 25.


TORC2 signaling pathway guarantees genome stability in the face of DNA strand breaks.

Shimada K, Filipuzzi I, Stahl M, Helliwell SB, Studer C, Hoepfner D, Seeber A, Loewith R, Movva NR, Gasser SM.

Mol Cell. 2013 Sep 26;51(6):829-39. doi: 10.1016/j.molcel.2013.08.019. Epub 2013 Sep 12.


The TORC2-Dependent Signaling Network in the Yeast Saccharomyces cerevisiae.

Roelants FM, Leskoske KL, Martinez Marshall MN, Locke MN, Thorner J.

Biomolecules. 2017 Sep 5;7(3). pii: E66. doi: 10.3390/biom7030066. Review.


Orm proteins integrate multiple signals to maintain sphingolipid homeostasis.

Gururaj C, Federman RS, Chang A.

J Biol Chem. 2013 Jul 12;288(28):20453-63. doi: 10.1074/jbc.M113.472860. Epub 2013 Jun 4. Erratum in: J Biol Chem. 2015 Jan 16;290(3):1455. Federman, Ross [corrected to Federman, Ross S].


Genome-wide identification of Saccharomyces cerevisiae genes required for tolerance to acetic acid.

Mira NP, Palma M, Guerreiro JF, Sá-Correia I.

Microb Cell Fact. 2010 Oct 25;9:79. doi: 10.1186/1475-2859-9-79.

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