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Items: 1 to 20 of 101

1.

A Selective Galactose-Coumarin-Derived Galectin-3 Inhibitor Demonstrates Involvement of Galectin-3-glycan Interactions in a Pulmonary Fibrosis Model.

Rajput VK, MacKinnon A, Mandal S, Collins P, Blanchard H, Leffler H, Sethi T, Schambye H, Mukhopadhyay B, Nilsson UJ.

J Med Chem. 2016 Sep 8;59(17):8141-7. doi: 10.1021/acs.jmedchem.6b00957. Epub 2016 Aug 23.

PMID:
27500311
2.

Galectin-3-Binding Glycomimetics that Strongly Reduce Bleomycin-Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition.

Delaine T, Collins P, MacKinnon A, Sharma G, Stegmayr J, Rajput VK, Mandal S, Cumpstey I, Larumbe A, Salameh BA, Kahl-Knutsson B, van Hattum H, van Scherpenzeel M, Pieters RJ, Sethi T, Schambye H, Oredsson S, Leffler H, Blanchard H, Nilsson UJ.

Chembiochem. 2016 Sep 15;17(18):1759-70. doi: 10.1002/cbic.201600285. Epub 2016 Aug 12.

PMID:
27356186
3.

1H-1,2,3-triazol-1-yl thiodigalactoside derivatives as high affinity galectin-3 inhibitors.

Salameh BA, Cumpstey I, Sundin A, Leffler H, Nilsson UJ.

Bioorg Med Chem. 2010 Jul 15;18(14):5367-78. doi: 10.1016/j.bmc.2010.05.040. Epub 2010 May 20.

PMID:
20538469
4.

Systematic Tuning of Fluoro-galectin-3 Interactions Provides Thiodigalactoside Derivatives with Single-Digit nM Affinity and High Selectivity.

Peterson K, Kumar R, Stenström O, Verma P, Verma PR, Håkansson M, Kahl-Knutsson B, Zetterberg F, Leffler H, Akke M, Logan DT, Nilsson UJ.

J Med Chem. 2018 Feb 8;61(3):1164-1175. doi: 10.1021/acs.jmedchem.7b01626. Epub 2018 Jan 11.

5.

Arginine binding motifs: design and synthesis of galactose-derived arginine tweezers as galectin-3 inhibitors.

Oberg CT, Leffler H, Nilsson UJ.

J Med Chem. 2008 Apr 10;51(7):2297-301. doi: 10.1021/jm701266y. Epub 2008 Mar 5.

PMID:
18318467
6.

C2-symmetrical thiodigalactoside bis-benzamido derivatives as high-affinity inhibitors of galectin-3: efficient lectin inhibition through double arginine-arene interactions.

Cumpstey I, Sundin A, Leffler H, Nilsson UJ.

Angew Chem Int Ed Engl. 2005 Aug 12;44(32):5110-2. No abstract available.

PMID:
16007713
7.

Thiodigalactoside-Bovine Serum Albumin Conjugates as High-Potency Inhibitors of Galectin-3: An Outstanding Example of Multivalent Presentation of Small Molecule Inhibitors.

Zhang H, Laaf D, Elling L, Pieters RJ.

Bioconjug Chem. 2018 Apr 18;29(4):1266-1275. doi: 10.1021/acs.bioconjchem.8b00047. Epub 2018 Mar 7.

8.

Tuning the preference of thiodigalactoside- and lactosamine-based ligands to galectin-3 over galectin-1.

van Hattum H, Branderhorst HM, Moret EE, Nilsson UJ, Leffler H, Pieters RJ.

J Med Chem. 2013 Feb 14;56(3):1350-4. doi: 10.1021/jm301677r. Epub 2013 Jan 23.

PMID:
23281927
9.

Investigation into the feasibility of thioditaloside as a novel scaffold for galectin-3-specific inhibitors.

Bum-Erdene K, Gagarinov IA, Collins PM, Winger M, Pearson AG, Wilson JC, Leffler H, Nilsson UJ, Grice ID, Blanchard H.

Chembiochem. 2013 Jul 22;14(11):1331-42. doi: 10.1002/cbic.201300245.

PMID:
23864426
10.

Inhibition mechanism of human galectin-7 by a novel galactose-benzylphosphate inhibitor.

Masuyer G, Jabeen T, Öberg CT, Leffler H, Nilsson UJ, Acharya KR.

FEBS J. 2012 Jan;279(2):193-202. doi: 10.1111/j.1742-4658.2011.08414.x. Epub 2011 Nov 30.

11.

Regulation of transforming growth factor-β1-driven lung fibrosis by galectin-3.

Mackinnon AC, Gibbons MA, Farnworth SL, Leffler H, Nilsson UJ, Delaine T, Simpson AJ, Forbes SJ, Hirani N, Gauldie J, Sethi T.

Am J Respir Crit Care Med. 2012 Mar 1;185(5):537-46. doi: 10.1164/rccm.201106-0965OC. Epub 2011 Nov 17.

12.

Synthesis and evaluation of new thiodigalactoside-based chemical probes to label galectin-3.

van Scherpenzeel M, Moret EE, Ballell L, Liskamp RM, Nilsson UJ, Leffler H, Pieters RJ.

Chembiochem. 2009 Jul 6;10(10):1724-33. doi: 10.1002/cbic.200900198.

PMID:
19492387
13.

Synthesis of stable and selective inhibitors of human galectins-1 and -3.

Giguère D, Bonin MA, Cloutier P, Patnam R, St-Pierre C, Sato S, Roy R.

Bioorg Med Chem. 2008 Aug 15;16(16):7811-23. doi: 10.1016/j.bmc.2008.06.044. Epub 2008 Jun 26.

PMID:
18674915
14.

3-(1,2,3-Triazol-1-yl)-1-thio-galactosides as small, efficient, and hydrolytically stable inhibitors of galectin-3.

Salameh BA, Leffler H, Nilsson UJ.

Bioorg Med Chem Lett. 2005 Jul 15;15(14):3344-6.

PMID:
15963723
15.

Inhibition of galectins with small molecules.

Oberg CT, Leffler H, Nilsson UJ.

Chimia (Aarau). 2011;65(1-2):18-23. Review.

PMID:
21469439
16.

Dissecting the Structure-Activity Relationship of Galectin-Ligand Interactions.

Chan YC, Lin HY, Tu Z, Kuo YH, Hsu SD, Lin CH.

Int J Mol Sci. 2018 Jan 29;19(2). pii: E392. doi: 10.3390/ijms19020392. Review.

17.

Galectin inhibitory disaccharides promote tumour immunity in a breast cancer model.

Stannard KA, Collins PM, Ito K, Sullivan EM, Scott SA, Gabutero E, Darren Grice I, Low P, Nilsson UJ, Leffler H, Blanchard H, Ralph SJ.

Cancer Lett. 2010 Dec 28;299(2):95-110. doi: 10.1016/j.canlet.2010.08.005. Epub 2010 Sep 9.

PMID:
20826047
18.

Aryl O- and S-galactosides and lactosides as specific inhibitors of human galectins-1 and -3: role of electrostatic potential at O-3.

Giguère D, Sato S, St-Pierre C, Sirois S, Roy R.

Bioorg Med Chem Lett. 2006 Mar 15;16(6):1668-72. Epub 2006 Jan 5.

PMID:
16403629
19.

Human galectin-3 selective and high affinity inhibitors. Present state and future perspectives.

Téllez-Sanz R, García-Fuentes L, Vargas-Berenguel A.

Curr Med Chem. 2013;20(24):2979-90. Review.

PMID:
23834183
20.

Development of an AlphaScreen assay for discovery of inhibitors of low-affinity glycan-lectin interactions.

Yegorova S, Chavaroche AE, Rodriguez MC, Minond D, Cudic M.

Anal Biochem. 2013 Aug 15;439(2):123-31. doi: 10.1016/j.ab.2013.04.028. Epub 2013 May 16.

PMID:
23685052

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