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Items: 1 to 20 of 80

1.

Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170.

Dunning AM, Michailidou K, Kuchenbaecker KB, Thompson D, French JD, Beesley J, Healey CS, Kar S, Pooley KA, Lopez-Knowles E, Dicks E, Barrowdale D, Sinnott-Armstrong NA, Sallari RC, Hillman KM, Kaufmann S, Sivakumaran H, Moradi Marjaneh M, Lee JS, Hills M, Jarosz M, Drury S, Canisius S, Bolla MK, Dennis J, Wang Q, Hopper JL, Southey MC, Broeks A, Schmidt MK, Lophatananon A, Muir K, Beckmann MW, Fasching PA, Dos-Santos-Silva I, Peto J, Sawyer EJ, Tomlinson I, Burwinkel B, Marme F, Guénel P, Truong T, Bojesen SE, Flyger H, González-Neira A, Perez JI, Anton-Culver H, Eunjung L, Arndt V, Brenner H, Meindl A, Schmutzler RK, Brauch H, Hamann U, Aittomäki K, Blomqvist C, Ito H, Matsuo K, Bogdanova N, Dörk T, Lindblom A, Margolin S, Kosma VM, Mannermaa A, Tseng CC, Wu AH, Lambrechts D, Wildiers H, Chang-Claude J, Rudolph A, Peterlongo P, Radice P, Olson JE, Giles GG, Milne RL, Haiman CA, Henderson BE, Goldberg MS, Teo SH, Yip CH, Nord S, Borresen-Dale AL, Kristensen V, Long J, Zheng W, Pylkäs K, Winqvist R, Andrulis IL, Knight JA, Devilee P, Seynaeve C, Figueroa J, Sherman ME, Czene K, Darabi H, Hollestelle A, van den Ouweland AM, Humphreys K, Gao YT, Shu XO, Cox A, Cross SS, Blot W, Cai Q, Ghoussaini M, Perkins BJ, Shah M, Choi JY, Kang D, Lee SC, Hartman M, Kabisch M, Torres D, Jakubowska A, Lubinski J, Brennan P, Sangrajrang S, Ambrosone CB, Toland AE, Shen CY, Wu PE, Orr N, Swerdlow A, McGuffog L, Healey S, Lee A, Kapuscinski M, John EM, Terry MB, Daly MB, Goldgar DE, Buys SS, Janavicius R, Tihomirova L, Tung N, Dorfling CM, van Rensburg EJ, Neuhausen SL, Ejlertsen B, Hansen TV, Osorio A, Benitez J, Rando R, Weitzel JN, Bonanni B, Peissel B, Manoukian S, Papi L, Ottini L, Konstantopoulou I, Apostolou P, Garber J, Rashid MU, Frost D; EMBRACE, Izatt L, Ellis S, Godwin AK, Arnold N, Niederacher D, Rhiem K, Bogdanova-Markov N, Sagne C, Stoppa-Lyonnet D, Damiola F; GEMO Study Collaborators, Sinilnikova OM, Mazoyer S, Isaacs C, Claes KB, De Leeneer K, de la Hoya M, Caldes T, Nevanlinna H, Khan S, Mensenkamp AR; HEBON, Hooning MJ, Rookus MA, Kwong A, Olah E, Diez O, Brunet J, Pujana MA, Gronwald J, Huzarski T, Barkardottir RB, Laframboise R, Soucy P, Montagna M, Agata S, Teixeira MR; kConFab Investigators, Park SK, Lindor N, Couch FJ, Tischkowitz M, Foretova L, Vijai J, Offit K, Singer CF, Rappaport C, Phelan CM, Greene MH, Mai PL, Rennert G, Imyanitov EN, Hulick PJ, Phillips KA, Piedmonte M, Mulligan AM, Glendon G, Bojesen A, Thomassen M, Caligo MA, Yoon SY, Friedman E, Laitman Y, Borg A, von Wachenfeldt A, Ehrencrona H, Rantala J, Olopade OI, Ganz PA, Nussbaum RL, Gayther SA, Nathanson KL, Domchek SM, Arun BK, Mitchell G, Karlan BY, Lester J, Maskarinec G, Woolcott C, Scott C, Stone J, Apicella C, Tamimi R, Luben R, Khaw KT, Helland Å, Haakensen V, Dowsett M, Pharoah PD, Simard J, Hall P, García-Closas M, Vachon C, Chenevix-Trench G, Antoniou AC, Easton DF, Edwards SL.

Nat Genet. 2016 Apr;48(4):374-86. doi: 10.1038/ng.3521. Epub 2016 Feb 29.

2.

C6ORF97-ESR1 breast cancer susceptibility locus: influence on progression and survival in breast cancer patients.

Yamamoto-Ibusuki M, Yamamoto Y, Fujiwara S, Sueta A, Yamamoto S, Hayashi M, Tomiguchi M, Takeshita T, Iwase H.

Eur J Hum Genet. 2015 Jul;23(7):949-56. doi: 10.1038/ejhg.2014.219. Epub 2014 Nov 5.

3.

Evaluation of functional genetic variants at 6q25.1 and risk of breast cancer in a Chinese population.

Wang Y, He Y, Qin Z, Jiang Y, Jin G, Ma H, Dai J, Chen J, Hu Z, Guan X, Shen H.

Breast Cancer Res. 2014 Aug 14;16(4):422. doi: 10.1186/s13058-014-0422-x.

4.

Genetic variation of ESR1 and its co-activator PPARGC1B is synergistic in augmenting the risk of estrogen receptor-positive breast cancer.

Li Y, Li Y, Wedrén S, Li G, Charn TH, Desai KV, Bonnard C, Czene K, Humphreys K, Darabi H, Einarsdóttir K, Heikkinen T, Aittomäki K, Blomqvist C, Chia KS, Nevanlinna H, Hall P, Liu ET, Liu J.

Breast Cancer Res. 2011 Jan 26;13(1):R10. doi: 10.1186/bcr2817.

5.

ESR1 is co-expressed with closely adjacent uncharacterised genes spanning a breast cancer susceptibility locus at 6q25.1.

Dunbier AK, Anderson H, Ghazoui Z, Lopez-Knowles E, Pancholi S, Ribas R, Drury S, Sidhu K, Leary A, Martin LA, Dowsett M.

PLoS Genet. 2011 Apr;7(4):e1001382. doi: 10.1371/journal.pgen.1001382. Epub 2011 Apr 28.

6.

Recurrent ESR1-CCDC170 rearrangements in an aggressive subset of oestrogen receptor-positive breast cancers.

Veeraraghavan J, Tan Y, Cao XX, Kim JA, Wang X, Chamness GC, Maiti SN, Cooper LJ, Edwards DP, Contreras A, Hilsenbeck SG, Chang EC, Schiff R, Wang XS.

Nat Commun. 2014 Aug 7;5:4577. doi: 10.1038/ncomms5577.

7.

The Protein Encoded by the CCDC170 Breast Cancer Gene Functions to Organize the Golgi-Microtubule Network.

Jiang P, Li Y, Poleshko A, Medvedeva V, Baulina N, Zhang Y, Zhou Y, Slater CM, Pellegrin T, Wasserman J, Lindy M, Efimov A, Daly M, Katz RA, Chen X.

EBioMedicine. 2017 Aug;22:28-43. doi: 10.1016/j.ebiom.2017.06.024. Epub 2017 Jun 27.

8.

Polymorphisms in the estrogen receptor alpha gene (ESR1), daily cycling estrogen and mammographic density phenotypes.

Fjeldheim FN, Frydenberg H, Flote VG, McTiernan A, Furberg AS, Ellison PT, Barrett ES, Wilsgaard T, Jasienska G, Ursin G, Wist EA, Thune I.

BMC Cancer. 2016 Oct 7;16(1):776.

9.

Genome-wide association study using family-based cohorts identifies the WLS and CCDC170/ESR1 loci as associated with bone mineral density.

Mullin BH, Walsh JP, Zheng HF, Brown SJ, Surdulescu GL, Curtis C, Breen G, Dudbridge F, Richards JB, Spector TD, Wilson SG.

BMC Genomics. 2016 Feb 25;17:136. doi: 10.1186/s12864-016-2481-0.

10.

Admixture mapping identifies a locus on 6q25 associated with breast cancer risk in US Latinas.

Fejerman L, Chen GK, Eng C, Huntsman S, Hu D, Williams A, Pasaniuc B, John EM, Via M, Gignoux C, Ingles S, Monroe KR, Kolonel LN, Torres-Mejía G, Pérez-Stable EJ, Burchard EG, Henderson BE, Haiman CA, Ziv E.

Hum Mol Genet. 2012 Apr 15;21(8):1907-17. doi: 10.1093/hmg/ddr617. Epub 2012 Jan 6.

11.

Evaluation of potential regulatory function of breast cancer risk locus at 6q25.1.

Sun Y, Ye C, Guo X, Wen W, Long J, Gao YT, Shu XO, Zheng W, Cai Q.

Carcinogenesis. 2016 Feb;37(2):163-168. doi: 10.1093/carcin/bgv170. Epub 2015 Dec 8.

12.

ESR1 gene promoter region methylation in free circulating DNA and its correlation with estrogen receptor protein expression in tumor tissue in breast cancer patients.

Martínez-Galán J, Torres-Torres B, Núñez MI, López-Peñalver J, Del Moral R, Ruiz De Almodóvar JM, Menjón S, Concha A, Chamorro C, Ríos S, Delgado JR.

BMC Cancer. 2014 Feb 4;14:59. doi: 10.1186/1471-2407-14-59.

13.

Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1.

Zheng W, Long J, Gao YT, Li C, Zheng Y, Xiang YB, Wen W, Levy S, Deming SL, Haines JL, Gu K, Fair AM, Cai Q, Lu W, Shu XO.

Nat Genet. 2009 Mar;41(3):324-8. doi: 10.1038/ng.318. Epub 2009 Feb 15.

14.

Noncoding somatic and inherited single-nucleotide variants converge to promote ESR1 expression in breast cancer.

Bailey SD, Desai K, Kron KJ, Mazrooei P, Sinnott-Armstrong NA, Treloar AE, Dowar M, Thu KL, Cescon DW, Silvester J, Yang SY, Wu X, Pezo RC, Haibe-Kains B, Mak TW, Bedard PL, Pugh TJ, Sallari RC, Lupien M.

Nat Genet. 2016 Oct;48(10):1260-6. doi: 10.1038/ng.3650. Epub 2016 Aug 29.

15.

Analysis of the ERalpha germline PvuII marker in breast cancer risk.

González-Mancha R, Galán JJ, Crespo C, Iglesias Pérez L, González-Perez A, Morón FJ, Moreno Nogueira JA, Real LM, Pascual MH, Ruiz A, Royo JL.

Med Sci Monit. 2008 Mar;14(3):CR136-43.

PMID:
18301357
16.

ESR1 single nucleotide polymorphism rs1062577 (c.*3804T>A) alters the susceptibility of breast cancer risk in Iranian population.

Dehghan Z, Sadeghi S, Tabatabaeian H, Ghaedi K, Azadeh M, Fazilati M, Bagheri F.

Gene. 2017 May 5;611:9-14. doi: 10.1016/j.gene.2017.02.016. Epub 2017 Feb 23.

PMID:
28216037
17.

Variants in 6q25.1 Are Associated with Mammographic Density in Malaysian Chinese Women.

Mariapun S, Ho WK, Kang PC, Li J, Lindström S, Yip CH, Teo SH.

Cancer Epidemiol Biomarkers Prev. 2016 Feb;25(2):327-33. doi: 10.1158/1055-9965.EPI-15-0746. Epub 2015 Dec 16.

18.

Breast Cancer Risk Variants Affect Estrogen Receptor.

[No authors listed]

Cancer Discov. 2016 May;6(5):OF3. doi: 10.1158/2159-8290.CD-NB2016-028. Epub 2016 Mar 21.

19.

FGFR2 risk SNPs confer breast cancer risk by augmenting oestrogen responsiveness.

Campbell TM, Castro MAA, de Santiago I, Fletcher MNC, Halim S, Prathalingam R, Ponder BAJ, Meyer KB.

Carcinogenesis. 2016 Aug;37(8):741-750. doi: 10.1093/carcin/bgw065. Epub 2016 May 28.

20.

Multimodal Assessment of Estrogen Receptor mRNA Profiles to Quantify Estrogen Pathway Activity in Breast Tumors.

Muthukaruppan A, Lasham A, Woad KJ, Black MA, Blenkiron C, Miller LD, Harris G, McCarthy N, Findlay MP, Shelling AN, Print CG.

Clin Breast Cancer. 2017 Apr;17(2):139-153. doi: 10.1016/j.clbc.2016.09.001. Epub 2016 Sep 13.

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