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Items: 1 to 20 of 104

1.

Inhibition of Chikungunya Virus-Induced Cell Death by Salicylate-Derived Bryostatin Analogues Provides Additional Evidence for a PKC-Independent Pathway.

Staveness D, Abdelnabi R, Near KE, Nakagawa Y, Neyts J, Delang L, Leyssen P, Wender PA.

J Nat Prod. 2016 Apr 22;79(4):680-4. doi: 10.1021/acs.jnatprod.5b01017. Epub 2016 Feb 22.

2.

Simplified Bryostatin Analogues Protect Cells from Chikungunya Virus-Induced Cell Death.

Staveness D, Abdelnabi R, Schrier AJ, Loy BA, Verma VA, DeChristopher BA, Near KE, Neyts J, Delang L, Leyssen P, Wender PA.

J Nat Prod. 2016 Apr 22;79(4):675-9. doi: 10.1021/acs.jnatprod.5b01016. Epub 2016 Feb 22.

3.

Comparative analysis of the anti-chikungunya virus activity of novel bryostatin analogs confirms the existence of a PKC-independent mechanism.

Abdelnabi R, Staveness D, Near KE, Wender PA, Delang L, Neyts J, Leyssen P.

Biochem Pharmacol. 2016 Nov 15;120:15-21. doi: 10.1016/j.bcp.2016.09.020. Epub 2016 Sep 21.

4.

Improved protein kinase C affinity through final step diversification of a simplified salicylate-derived bryostatin analog scaffold.

Wender PA, Staveness D.

Org Lett. 2014 Oct 3;16(19):5140-3. doi: 10.1021/ol502492b. Epub 2014 Sep 19.

5.

Computer-guided design, synthesis, and protein kinase C affinity of a new salicylate-based class of bryostatin analogs.

Wender PA, Nakagawa Y, Near KE, Staveness D.

Org Lett. 2014 Oct 3;16(19):5136-9. doi: 10.1021/ol502491f. Epub 2014 Sep 19.

6.

Toward a biorelevant structure of protein kinase C bound modulators: design, synthesis, and evaluation of labeled bryostatin analogues for analysis with rotational echo double resonance NMR spectroscopy.

Loy BA, Lesser AB, Staveness D, Billingsley KL, Cegelski L, Wender PA.

J Am Chem Soc. 2015 Mar 18;137(10):3678-85. doi: 10.1021/jacs.5b00886. Epub 2015 Mar 4.

7.

Synthesis of a des-B-ring bryostatin analogue leads to an unexpected ring expansion of the bryolactone core.

Kraft MB, Poudel YB, Kedei N, Lewin NE, Peach ML, Blumberg PM, Keck GE.

J Am Chem Soc. 2014 Sep 24;136(38):13202-8. doi: 10.1021/ja5078188. Epub 2014 Sep 10.

8.

A cellular model of Alzheimer's disease therapeutic efficacy: PKC activation reverses Abeta-induced biomarker abnormality on cultured fibroblasts.

Khan TK, Nelson TJ, Verma VA, Wender PA, Alkon DL.

Neurobiol Dis. 2009 May;34(2):332-9. doi: 10.1016/j.nbd.2009.02.003. Epub 2009 Feb 20.

9.

Designed, synthetically accessible bryostatin analogues potently induce activation of latent HIV reservoirs in vitro.

DeChristopher BA, Loy BA, Marsden MD, Schrier AJ, Zack JA, Wender PA.

Nat Chem. 2012 Sep;4(9):705-10. doi: 10.1038/nchem.1395. Epub 2012 Jul 15.

10.

Marine natural products: bryostatins in preclinical and clinical studies.

Kollár P, Rajchard J, Balounová Z, Pazourek J.

Pharm Biol. 2014 Feb;52(2):237-42. doi: 10.3109/13880209.2013.804100. Epub 2013 Sep 13. Review.

PMID:
24033119
11.

Biological profile of the less lipophilic and synthetically more accessible bryostatin 7 closely resembles that of bryostatin 1.

Kedei N, Lewin NE, Géczy T, Selezneva J, Braun DC, Chen J, Herrmann MA, Heldman MR, Lim L, Mannan P, Garfield SH, Poudel YB, Cummins TJ, Rudra A, Blumberg PM, Keck GE.

ACS Chem Biol. 2013 Apr 19;8(4):767-77. doi: 10.1021/cb300671s. Epub 2013 Feb 1.

12.

The bryostatin 1 A-ring acetate is not the critical determinant for antagonism of phorbol ester-induced biological responses.

Keck GE, Li W, Kraft MB, Kedei N, Lewin NE, Blumberg PM.

Org Lett. 2009 Jun 4;11(11):2277-80. doi: 10.1021/ol900585t.

13.

Inhibition of chikungunya virus replication by harringtonine, a novel antiviral that suppresses viral protein expression.

Kaur P, Thiruchelvan M, Lee RC, Chen H, Chen KC, Ng ML, Chu JJ.

Antimicrob Agents Chemother. 2013 Jan;57(1):155-67. doi: 10.1128/AAC.01467-12. Epub 2012 Oct 22.

14.

The bryostatins inhibit growth of B16/F10 melanoma cells in vitro through a protein kinase C-independent mechanism: dissociation of activities using 26-epi-bryostatin 1.

Szallasi Z, Du L, Levine R, Lewin NE, Nguyen PN, Williams MD, Pettit GR, Blumberg PM.

Cancer Res. 1996 May 1;56(9):2105-11.

15.

Neristatin 1 provides critical insight into bryostatin 1 structure-function relationships.

Kedei N, Kraft MB, Keck GE, Herald CL, Melody N, Pettit GR, Blumberg PM.

J Nat Prod. 2015 Apr 24;78(4):896-900. doi: 10.1021/acs.jnatprod.5b00094. Epub 2015 Mar 26.

16.

Structure-activity relationship study of arbidol derivatives as inhibitors of chikungunya virus replication.

Di Mola A, Peduto A, La Gatta A, Delang L, Pastorino B, Neyts J, Leyssen P, de Rosa M, Filosa R.

Bioorg Med Chem. 2014 Nov 1;22(21):6014-25. doi: 10.1016/j.bmc.2014.09.013. Epub 2014 Sep 16.

PMID:
25282648
17.

A simple analogue of tumor-promoting aplysiatoxin is an antineoplastic agent rather than a tumor promoter: development of a synthetically accessible protein kinase C activator with bryostatin-like activity.

Nakagawa Y, Yanagita RC, Hamada N, Murakami A, Takahashi H, Saito N, Nagai H, Irie K.

J Am Chem Soc. 2009 Jun 10;131(22):7573-9. doi: 10.1021/ja808447r.

PMID:
19449873
18.

Evaluation of Chromane-Based Bryostatin Analogues Prepared via Hydrogen-Mediated C-C Bond Formation: Potency Does Not Confer Bryostatin-like Biology.

Ketcham JM, Volchkov I, Chen TY, Blumberg PM, Kedei N, Lewin NE, Krische MJ.

J Am Chem Soc. 2016 Oct 12;138(40):13415-13423. Epub 2016 Sep 27.

19.

Bryostatin-1 vs. TPPB: dose-dependent APP processing and PKC-α, -δ, and -ε isoform activation in SH-SY5Y neuronal cells.

Yi P, Schrott L, Castor TP, Alexander JS.

J Mol Neurosci. 2012 Sep;48(1):234-44. doi: 10.1007/s12031-012-9816-3. Epub 2012 Jun 15.

20.

Protein kinases C as potential host targets for the inhibition of chikungunya virus replication.

Abdelnabi R, Amrun SN, Ng LF, Leyssen P, Neyts J, Delang L.

Antiviral Res. 2017 Mar;139:79-87. doi: 10.1016/j.antiviral.2016.12.020. Epub 2016 Dec 27.

PMID:
28039020

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