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Cellular delivery and photochemical release of a caged inositol-pyrophosphate induces PH-domain translocation in cellulo.

Pavlovic I, Thakor DT, Vargas JR, McKinlay CJ, Hauke S, Anstaett P, Camuña RC, Bigler L, Gasser G, Schultz C, Wender PA, Jessen HJ.

Nat Commun. 2016 Feb 4;7:10622. doi: 10.1038/ncomms10622.


Inositol pyrophosphates mediate chemotaxis in Dictyostelium via pleckstrin homology domain-PtdIns(3,4,5)P3 interactions.

Luo HR, Huang YE, Chen JC, Saiardi A, Iijima M, Ye K, Huang Y, Nagata E, Devreotes P, Snyder SH.

Cell. 2003 Sep 5;114(5):559-72.


The Significance of the Bifunctional Kinase/Phosphatase Activities of Diphosphoinositol Pentakisphosphate Kinases (PPIP5Ks) for Coupling Inositol Pyrophosphate Cell Signaling to Cellular Phosphate Homeostasis.

Gu C, Nguyen HN, Hofer A, Jessen HJ, Dai X, Wang H, Shears SB.

J Biol Chem. 2017 Mar 17;292(11):4544-4555. doi: 10.1074/jbc.M116.765743. Epub 2017 Jan 26.


Cigarette smoke (CS) and nicotine delay neutrophil spontaneous death via suppressing production of diphosphoinositol pentakisphosphate.

Xu Y, Li H, Bajrami B, Kwak H, Cao S, Liu P, Zhou J, Zhou Y, Zhu H, Ye K, Luo HR.

Proc Natl Acad Sci U S A. 2013 May 7;110(19):7726-31. doi: 10.1073/pnas.1302906110. Epub 2013 Apr 22.


Hydrophilic interaction liquid chromatography-tandem mass spectrometry for the quantitative analysis of mammalian-derived inositol poly/pyrophosphates.

Ito M, Fujii N, Wittwer C, Sasaki A, Tanaka M, Bittner T, Jessen HJ, Saiardi A, Takizawa S, Nagata E.

J Chromatogr A. 2018 Oct 26;1573:87-97. doi: 10.1016/j.chroma.2018.08.061. Epub 2018 Aug 31.


Asp1 from Schizosaccharomyces pombe binds a [2Fe-2S](2+) cluster which inhibits inositol pyrophosphate 1-phosphatase activity.

Wang H, Nair VS, Holland AA, Capolicchio S, Jessen HJ, Johnson MK, Shears SB.

Biochemistry. 2015 Oct 27;54(42):6462-74. doi: 10.1021/acs.biochem.5b00532. Epub 2015 Oct 9.


Two inositol hexakisphosphate kinases drive inositol pyrophosphate synthesis in plants.

Desai M, Rangarajan P, Donahue JL, Williams SP, Land ES, Mandal MK, Phillippy BQ, Perera IY, Raboy V, Gillaspy GE.

Plant J. 2014 Nov;80(4):642-53. doi: 10.1111/tpj.12669.


Understanding inositol pyrophosphate metabolism and function: kinetic characterization of the DIPPs.

Kilari RS, Weaver JD, Shears SB, Safrany ST.

FEBS Lett. 2013 Nov 1;587(21):3464-70. doi: 10.1016/j.febslet.2013.08.035. Epub 2013 Sep 8.


Inositol hexakisphosphate kinase 1 regulates neutrophil function in innate immunity by inhibiting phosphatidylinositol-(3,4,5)-trisphosphate signaling.

Prasad A, Jia Y, Chakraborty A, Li Y, Jain SK, Zhong J, Roy SG, Loison F, Mondal S, Sakai J, Blanchard C, Snyder SH, Luo HR.

Nat Immunol. 2011 Jun 19;12(8):752-60. doi: 10.1038/ni.2052.


Inositol Pyrophosphate Synthesis by Diphosphoinositol Pentakisphosphate Kinase-1 is Regulated by Phosphatidylinositol(4,5)bisphosphate.

Nair VS, Gu C, Janoshazi AK, Jessen HJ, Wang H, Shears SB.

Biosci Rep. 2018 Feb 19. pii: BSR20171549. doi: 10.1042/BSR20171549. [Epub ahead of print]


Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain.

Chakraborty A, Koldobskiy MA, Bello NT, Maxwell M, Potter JJ, Juluri KR, Maag D, Kim S, Huang AS, Dailey MJ, Saleh M, Snowman AM, Moran TH, Mezey E, Snyder SH.

Cell. 2010 Dec 10;143(6):897-910. doi: 10.1016/j.cell.2010.11.032.


Cell signalling by inositol pyrophosphates.

Saiardi A.

Subcell Biochem. 2012;59:413-43. doi: 10.1007/978-94-007-3015-1_14. Review.


Are inositol pyrophosphates signalling molecules?

Burton A, Hu X, Saiardi A.

J Cell Physiol. 2009 Jul;220(1):8-15. doi: 10.1002/jcp.21763. Review.


Synthesis of 2-diphospho-myo-inositol 1,3,4,5,6-pentakisphosphate and a photocaged analogue.

Pavlovic I, Thakor DT, Jessen HJ.

Org Biomol Chem. 2016 Jun 15;14(24):5559-62. doi: 10.1039/c6ob00094k.


Inositol pyrophosphates as mammalian cell signals.

Chakraborty A, Kim S, Snyder SH.

Sci Signal. 2011 Aug 23;4(188):re1. doi: 10.1126/scisignal.2001958. Review.


Specific inhibition of the Akt1 pleckstrin homology domain by D-3-deoxy-phosphatidyl-myo-inositol analogues.

Meuillet EJ, Mahadevan D, Vankayalapati H, Berggren M, Williams R, Coon A, Kozikowski AP, Powis G.

Mol Cancer Ther. 2003 Apr;2(4):389-99.


Inositol pyrophosphates: metabolism and signaling.

Bennett M, Onnebo SM, Azevedo C, Saiardi A.

Cell Mol Life Sci. 2006 Mar;63(5):552-64. Review.


Prometabolites of 5-Diphospho-myo-inositol Pentakisphosphate.

Pavlovic I, Thakor DT, Bigler L, Wilson MS, Laha D, Schaaf G, Saiardi A, Jessen HJ.

Angew Chem Int Ed Engl. 2015 Aug 10;54(33):9622-6. doi: 10.1002/anie.201503094. Epub 2015 May 27.


Inositol Pyrophosphate Profiling of Two HCT116 Cell Lines Uncovers Variation in InsP8 Levels.

Gu C, Wilson MS, Jessen HJ, Saiardi A, Shears SB.

PLoS One. 2016 Oct 27;11(10):e0165286. doi: 10.1371/journal.pone.0165286. eCollection 2016.


Ceramide impairs the insulin-dependent membrane recruitment of protein kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells.

Hajduch E, Balendran A, Batty IH, Litherland GJ, Blair AS, Downes CP, Hundal HS.

Diabetologia. 2001 Feb;44(2):173-83.


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