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Items: 1 to 20 of 102

1.

Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies.

Zuchero YJ, Chen X, Bien-Ly N, Bumbaca D, Tong RK, Gao X, Zhang S, Hoyte K, Luk W, Huntley MA, Phu L, Tan C, Kallop D, Weimer RM, Lu Y, Kirkpatrick DS, Ernst JA, Chih B, Dennis MS, Watts RJ.

Neuron. 2016 Jan 6;89(1):70-82. doi: 10.1016/j.neuron.2015.11.024. Epub 2015 Dec 10.

2.

Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target.

Yu YJ, Zhang Y, Kenrick M, Hoyte K, Luk W, Lu Y, Atwal J, Elliott JM, Prabhu S, Watts RJ, Dennis MS.

Sci Transl Med. 2011 May 25;3(84):84ra44. doi: 10.1126/scitranslmed.3002230.

3.

Brain uptake of multivalent and multi-specific DVD-Ig proteins after systemic administration.

Karaoglu Hanzatian D, Schwartz A, Gizatullin F, Erickson J, Deng K, Villanueva R, Stedman C, Harris C, Ghayur T, Goodearl A.

MAbs. 2018 Jul;10(5):765-777. doi: 10.1080/19420862.2018.1465159. Epub 2018 Jun 5.

PMID:
29771629
4.

Drug delivery: New targets for drug delivery across the BBB.

Kingwell K.

Nat Rev Drug Discov. 2016 Feb;15(2):84-5. doi: 10.1038/nrd.2016.14. Epub 2016 Jan 29. No abstract available.

PMID:
26822834
5.

Study of the transcytosis of an anti-transferrin receptor antibody with a Fab' cargo across the blood-brain barrier in mice.

Manich G, Cabezón I, del Valle J, Duran-Vilaregut J, Camins A, Pallàs M, Pelegrí C, Vilaplana J.

Eur J Pharm Sci. 2013 Jul 16;49(4):556-64. doi: 10.1016/j.ejps.2013.05.027. Epub 2013 Jun 7.

PMID:
23748097
6.

Increased brain uptake of targeted nanoparticles by adding an acid-cleavable linkage between transferrin and the nanoparticle core.

Clark AJ, Davis ME.

Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):12486-91. doi: 10.1073/pnas.1517048112. Epub 2015 Sep 21.

8.

Transcytosis and brain uptake of transferrin-containing nanoparticles by tuning avidity to transferrin receptor.

Wiley DT, Webster P, Gale A, Davis ME.

Proc Natl Acad Sci U S A. 2013 May 21;110(21):8662-7. doi: 10.1073/pnas.1307152110. Epub 2013 May 6.

9.

Sorting Tubules Regulate Blood-Brain Barrier Transcytosis.

Villaseñor R, Schilling M, Sundaresan J, Lutz Y, Collin L.

Cell Rep. 2017 Dec 12;21(11):3256-3270. doi: 10.1016/j.celrep.2017.11.055.

10.

Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates.

Yu YJ, Atwal JK, Zhang Y, Tong RK, Wildsmith KR, Tan C, Bien-Ly N, Hersom M, Maloney JA, Meilandt WJ, Bumbaca D, Gadkar K, Hoyte K, Luk W, Lu Y, Ernst JA, Scearce-Levie K, Couch JA, Dennis MS, Watts RJ.

Sci Transl Med. 2014 Nov 5;6(261):261ra154. doi: 10.1126/scitranslmed.3009835.

11.

Brain iron homeostasis.

Moos T.

Dan Med Bull. 2002 Nov;49(4):279-301. Review.

PMID:
12553165
12.

Endosomal trafficking regulates receptor-mediated transcytosis of antibodies across the blood brain barrier.

Haqqani AS, Delaney CE, Brunette E, Baumann E, Farrington GK, Sisk W, Eldredge J, Ding W, Tremblay TL, Stanimirovic DB.

J Cereb Blood Flow Metab. 2018 Apr;38(4):727-740. doi: 10.1177/0271678X17740031. Epub 2017 Nov 15.

13.

Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants.

Bien-Ly N, Yu YJ, Bumbaca D, Elstrott J, Boswell CA, Zhang Y, Luk W, Lu Y, Dennis MS, Weimer RM, Chung I, Watts RJ.

J Exp Med. 2014 Feb 10;211(2):233-44. doi: 10.1084/jem.20131660. Epub 2014 Jan 27.

14.

Mathematical PKPD and safety model of bispecific TfR/BACE1 antibodies for the optimization of antibody uptake in brain.

Gadkar K, Yadav DB, Zuchero JY, Couch JA, Kanodia J, Kenrick MK, Atwal JK, Dennis MS, Prabhu S, Watts RJ, Joseph SB, Ramanujan S.

Eur J Pharm Biopharm. 2016 Apr;101:53-61. doi: 10.1016/j.ejpb.2016.01.009. Epub 2016 Jan 25.

PMID:
26820920
15.

The blood-brain barrier transmigrating single domain antibody: mechanisms of transport and antigenic epitopes in human brain endothelial cells.

Abulrob A, Sprong H, Van Bergen en Henegouwen P, Stanimirovic D.

J Neurochem. 2005 Nov;95(4):1201-14.

16.

Revisiting nanoparticle technology for blood-brain barrier transport: Unfolding at the endothelial gate improves the fate of transferrin receptor-targeted liposomes.

Johnsen KB, Moos T.

J Control Release. 2016 Jan 28;222:32-46. doi: 10.1016/j.jconrel.2015.11.032. Epub 2015 Dec 3. Review.

PMID:
26658072
17.

Targeting rat anti-mouse transferrin receptor monoclonal antibodies through blood-brain barrier in mouse.

Lee HJ, Engelhardt B, Lesley J, Bickel U, Pardridge WM.

J Pharmacol Exp Ther. 2000 Mar;292(3):1048-52.

PMID:
10688622
18.

A novel human induced pluripotent stem cell blood-brain barrier model: Applicability to study antibody-triggered receptor-mediated transcytosis.

Ribecco-Lutkiewicz M, Sodja C, Haukenfrers J, Haqqani AS, Ly D, Zachar P, Baumann E, Ball M, Huang J, Rukhlova M, Martina M, Liu Q, Stanimirovic D, Jezierski A, Bani-Yaghoub M.

Sci Rep. 2018 Jan 30;8(1):1873. doi: 10.1038/s41598-018-19522-8.

19.

In vitro and in vivo methods for assessing FcRn-mediated reverse transcytosis across the blood-brain barrier.

Caram-Salas N, Boileau E, Farrington GK, Garber E, Brunette E, Abulrob A, Stanimirovic D.

Methods Mol Biol. 2011;763:383-401. doi: 10.1007/978-1-61779-191-8_26.

PMID:
21874466
20.

Transferrin receptor expression and role in transendothelial transport of transferrin in cultured brain endothelial monolayers.

Hersom M, Helms HC, Pretzer N, Goldeman C, Jensen AI, Severin G, Nielsen MS, Holm R, Brodin B.

Mol Cell Neurosci. 2016 Oct;76:59-67. doi: 10.1016/j.mcn.2016.08.009. Epub 2016 Aug 24.

PMID:
27567687

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