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Items: 1 to 20 of 101

1.

The HIV Protease Inhibitor Saquinavir Inhibits HMGB1-Driven Inflammation by Targeting the Interaction of Cathepsin V with TLR4/MyD88.

Pribis JP, Al-Abed Y, Yang H, Gero D, Xu H, Montenegro MF, Bauer EM, Kim S, Chavan SS, Cai C, Li T, Szoleczky P, Szabo C, Tracey KJ, Billiar TR.

Mol Med. 2015 Dec;21(1):749-757. doi: 10.2119/molmed.2015.00197. Epub 2015 Sep 2.

2.

Saquinavir Ameliorates Liver Warm Ischemia-Reperfusion-Induced Lung Injury via HMGB-1- and P38/JNK-Mediated TLR-4-Dependent Signaling Pathways.

Yu Z, Tong Y, Zhang R, Ding X, Li Q.

Mediators Inflamm. 2017;2017:7083528. doi: 10.1155/2017/7083528. Epub 2017 Dec 26.

3.

HMGB1-Driven Inflammation and Intimal Hyperplasia After Arterial Injury Involves Cell-Specific Actions Mediated by TLR4.

Cai J, Yuan H, Wang Q, Yang H, Al-Abed Y, Hua Z, Wang J, Chen D, Wu J, Lu B, Pribis JP, Jiang W, Yang K, Hackam DJ, Tracey KJ, Billiar TR, Chen AF.

Arterioscler Thromb Vasc Biol. 2015 Dec;35(12):2579-93. doi: 10.1161/ATVBAHA.115.305789. Epub 2015 Oct 29.

4.

High-mobility group box 1 protein is involved in the protective effect of Saquinavir on ventilation-induced lung injury in mice.

Wang X, Zhang R, Tong Y, Ding X, Jin S, Zhao X, Zong J, Chen Z, Billiar TR, Li Q.

Acta Biochim Biophys Sin (Shanghai). 2017 Oct 1;49(10):907-915. doi: 10.1093/abbs/gmx085.

PMID:
28981603
5.

Saquinavir plus methylprednisolone ameliorates experimental acute lung injury.

Zhang G, Zhang X, Huang H, Ji Y, Li D, Jiang W.

Braz J Med Biol Res. 2018 Aug 6;51(10):e7579. doi: 10.1590/1414-431X20187579.

6.

Cathepsin L promotes Vascular Intimal Hyperplasia after Arterial Injury.

Cai J, Zhong H, Wu J, Chen RF, Yang H, Al-Abed Y, Li Y, Li X, Jiang W, Montenegro MF, Yuan H, Billiar T, Chen AF.

Mol Med. 2017 Jun;23:92-100. doi: 10.2119/molmed.2016.00222. Epub 2016 Mar 20.

7.

Toll-like receptor 4 (TLR4) antagonist eritoran tetrasodium attenuates liver ischemia and reperfusion injury through inhibition of high-mobility group box protein B1 (HMGB1) signaling.

Mcdonald KA, Huang H, Tohme S, Loughran P, Ferrero K, Billiar T, Tsung A.

Mol Med. 2015 Mar 13;20:639-48. doi: 10.2119/molmed.2014.00076.

8.
9.

MD-2 is required for disulfide HMGB1-dependent TLR4 signaling.

Yang H, Wang H, Ju Z, Ragab AA, Lundbäck P, Long W, Valdes-Ferrer SI, He M, Pribis JP, Li J, Lu B, Gero D, Szabo C, Antoine DJ, Harris HE, Golenbock DT, Meng J, Roth J, Chavan SS, Andersson U, Billiar TR, Tracey KJ, Al-Abed Y.

J Exp Med. 2015 Jan 12;212(1):5-14. doi: 10.1084/jem.20141318. Epub 2015 Jan 5.

10.

Overexpression of HMGB1 A-box reduced lipopolysaccharide-induced intestinal inflammation via HMGB1/TLR4 signaling in vitro.

Wang FC, Pei JX, Zhu J, Zhou NJ, Liu DS, Xiong HF, Liu XQ, Lin DJ, Xie Y.

World J Gastroenterol. 2015 Jul 7;21(25):7764-76. doi: 10.3748/wjg.v21.i25.7764.

11.

Signaling of high mobility group box 1 (HMGB1) through toll-like receptor 4 in macrophages requires CD14.

Kim S, Kim SY, Pribis JP, Lotze M, Mollen KP, Shapiro R, Loughran P, Scott MJ, Billiar TR.

Mol Med. 2013 May 20;19:88-98. doi: 10.2119/molmed.2012.00306.

12.

Hemorrhagic shock induces NAD(P)H oxidase activation in neutrophils: role of HMGB1-TLR4 signaling.

Fan J, Li Y, Levy RM, Fan JJ, Hackam DJ, Vodovotz Y, Yang H, Tracey KJ, Billiar TR, Wilson MA.

J Immunol. 2007 May 15;178(10):6573-80.

13.

Mechanisms of Toll-like receptor 4 (TLR4)-mediated inflammation after cold ischemia/reperfusion in the heart.

Kaczorowski DJ, Nakao A, Vallabhaneni R, Mollen KP, Sugimoto R, Kohmoto J, Zuckerbraun BS, McCurry KR, Billiar TR.

Transplantation. 2009 May 27;87(10):1455-63. doi: 10.1097/TP.0b013e3181a36e5e.

14.

Synthesis of poly(ethylene glycol)-based saquinavir prodrug conjugates and assessment of release and anti-HIV-1 bioactivity using a novel protease inhibition assay.

Gunaseelan S, Debrah O, Wan L, Leibowitz MJ, Rabson AB, Stein S, Sinko PJ.

Bioconjug Chem. 2004 Nov-Dec;15(6):1322-33.

PMID:
15546199
15.

ASC/caspase-1/IL-1β signaling triggers inflammatory responses by promoting HMGB1 induction in liver ischemia/reperfusion injury.

Kamo N, Ke B, Ghaffari AA, Shen XD, Busuttil RW, Cheng G, Kupiec-Weglinski JW.

Hepatology. 2013 Jul;58(1):351-62. doi: 10.1002/hep.26320. Epub 2013 May 15.

16.

Mechanistic Insights into High Mobility Group Box-1 (HMGb1) induced Toll-like Receptor 4 (TLR4) Dimer Formation.

Sun S, He M, VanPatten S, Al-Abed Y.

J Biomol Struct Dyn. 2018 Sep 21:1-30. doi: 10.1080/07391102.2018.1526712. [Epub ahead of print]

PMID:
30238832
17.

Modulation of diabetes-related liver injury by the HMGB1/TLR4 inflammatory pathway.

Jovanović Stojanov S, Martinović V, Bogojević D, Poznanović G, Petrović A, Ivanović-Matić S, Grigorov I.

J Physiol Biochem. 2018 May;74(2):345-358. doi: 10.1007/s13105-018-0626-0. Epub 2018 Apr 2.

PMID:
29611132
18.

TLR4-HMGB1-, MyD88- and TRIF-dependent signaling in mouse intestinal ischemia/reperfusion injury.

Wang J, He GZ, Wang YK, Zhu QK, Chen W, Guo T.

World J Gastroenterol. 2015 Jul 21;21(27):8314-25. doi: 10.3748/wjg.v21.i27.8314.

19.

Extracellular high mobility group box-1 (HMGB1) inhibits enterocyte migration via activation of Toll-like receptor-4 and increased cell-matrix adhesiveness.

Dai S, Sodhi C, Cetin S, Richardson W, Branca M, Neal MD, Prindle T, Ma C, Shapiro RA, Li B, Wang JH, Hackam DJ.

J Biol Chem. 2010 Feb 12;285(7):4995-5002. doi: 10.1074/jbc.M109.067454. Epub 2009 Dec 11.

20.

High mobility group box protein 1 (HMGB1)-partner molecule complexes enhance cytokine production by signaling through the partner molecule receptor.

Hreggvidsdóttir HS, Lundberg AM, Aveberger AC, Klevenvall L, Andersson U, Harris HE.

Mol Med. 2012 Mar 27;18:224-30. doi: 10.2119/molmed.2011.00327.

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