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Items: 1 to 20 of 91

1.

Amino Acid Activation of mTORC1 by a PB1-Domain-Driven Kinase Complex Cascade.

Linares JF, Duran A, Reina-Campos M, Aza-Blanc P, Campos A, Moscat J, Diaz-Meco MT.

Cell Rep. 2015 Aug 25;12(8):1339-52. doi: 10.1016/j.celrep.2015.07.045. Epub 2015 Aug 13.

2.

K63 polyubiquitination and activation of mTOR by the p62-TRAF6 complex in nutrient-activated cells.

Linares JF, Duran A, Yajima T, Pasparakis M, Moscat J, Diaz-Meco MT.

Mol Cell. 2013 Aug 8;51(3):283-96. doi: 10.1016/j.molcel.2013.06.020. Epub 2013 Aug 1.

3.

PB1 domain interaction of p62/sequestosome 1 and MEKK3 regulates NF-kappaB activation.

Nakamura K, Kimple AJ, Siderovski DP, Johnson GL.

J Biol Chem. 2010 Jan 15;285(3):2077-89. doi: 10.1074/jbc.M109.065102. Epub 2009 Nov 10.

4.

p62 is a key regulator of nutrient sensing in the mTORC1 pathway.

Duran A, Amanchy R, Linares JF, Joshi J, Abu-Baker S, Porollo A, Hansen M, Moscat J, Diaz-Meco MT.

Mol Cell. 2011 Oct 7;44(1):134-46. doi: 10.1016/j.molcel.2011.06.038.

5.

Metabolic reprogramming of stromal fibroblasts through p62-mTORC1 signaling promotes inflammation and tumorigenesis.

Valencia T, Kim JY, Abu-Baker S, Moscat-Pardos J, Ahn CS, Reina-Campos M, Duran A, Castilla EA, Metallo CM, Diaz-Meco MT, Moscat J.

Cancer Cell. 2014 Jul 14;26(1):121-135. doi: 10.1016/j.ccr.2014.05.004. Epub 2014 Jul 4.

6.

GSK3-mediated raptor phosphorylation supports amino-acid-dependent mTORC1-directed signalling.

Stretton C, Hoffmann TM, Munson MJ, Prescott A, Taylor PM, Ganley IG, Hundal HS.

Biochem J. 2015 Sep 1;470(2):207-21. doi: 10.1042/BJ20150404. Epub 2015 Jul 9.

7.

The ubiquitination of rag A GTPase by RNF152 negatively regulates mTORC1 activation.

Deng L, Jiang C, Chen L, Jin J, Wei J, Zhao L, Chen M, Pan W, Xu Y, Chu H, Wang X, Ge X, Li D, Liao L, Liu M, Li L, Wang P.

Mol Cell. 2015 Jun 4;58(5):804-18. doi: 10.1016/j.molcel.2015.03.033. Epub 2015 Apr 30.

8.

Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.

Ichimura Y, Waguri S, Sou YS, Kageyama S, Hasegawa J, Ishimura R, Saito T, Yang Y, Kouno T, Fukutomi T, Hoshii T, Hirao A, Takagi K, Mizushima T, Motohashi H, Lee MS, Yoshimori T, Tanaka K, Yamamoto M, Komatsu M.

Mol Cell. 2013 Sep 12;51(5):618-31. doi: 10.1016/j.molcel.2013.08.003. Epub 2013 Sep 5.

9.
10.

p62/SQSTM1 functions as a signaling hub and an autophagy adaptor.

Katsuragi Y, Ichimura Y, Komatsu M.

FEBS J. 2015 Dec;282(24):4672-8. doi: 10.1111/febs.13540. Epub 2015 Oct 16. Review.

11.

Autophagy modulates amino acid signaling network in myotubes: differential effects on mTORC1 pathway and the integrated stress response.

Yu X, Long YC.

FASEB J. 2015 Feb;29(2):394-407. doi: 10.1096/fj.14-252841. Epub 2014 Nov 5.

PMID:
25376834
12.

Absence of lipofuscin in motor neurons of SOD1-linked ALS mice.

Bandyopadhyay U, Nagy M, Fenton WA, Horwich AL.

Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):11055-60. doi: 10.1073/pnas.1409314111. Epub 2014 Jul 14.

13.

Disruption of the Rag-Ragulator Complex by c17orf59 Inhibits mTORC1.

Schweitzer LD, Comb WC, Bar-Peled L, Sabatini DM.

Cell Rep. 2015 Sep 1;12(9):1445-55. doi: 10.1016/j.celrep.2015.07.052. Epub 2015 Aug 20.

14.

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.

Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S, Sabatini DM.

Cell. 2010 Apr 16;141(2):290-303. doi: 10.1016/j.cell.2010.02.024. Epub 2010 Apr 8.

16.

Requirement for lysosomal localization of mTOR for its activation differs between leucine and other amino acids.

Averous J, Lambert-Langlais S, Carraro V, Gourbeyre O, Parry L, B'Chir W, Muranishi Y, Jousse C, Bruhat A, Maurin AC, Proud CG, Fafournoux P.

Cell Signal. 2014 Sep;26(9):1918-27. doi: 10.1016/j.cellsig.2014.04.019. Epub 2014 May 2.

PMID:
24793303
17.

The p62 scaffold regulates nerve growth factor-induced NF-kappaB activation by influencing TRAF6 polyubiquitination.

Wooten MW, Geetha T, Seibenhener ML, Babu JR, Diaz-Meco MT, Moscat J.

J Biol Chem. 2005 Oct 21;280(42):35625-9. Epub 2005 Aug 3.

18.
19.

Pharmacological inhibition of lysosomes activates the MTORC1 signaling pathway in chondrocytes in an autophagy-independent manner.

Newton PT, Vuppalapati KK, Bouderlique T, Chagin AS.

Autophagy. 2015;11(9):1594-607. doi: 10.1080/15548627.2015.1068489.

20.

Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent.

Parkhitko A, Myachina F, Morrison TA, Hindi KM, Auricchio N, Karbowniczek M, Wu JJ, Finkel T, Kwiatkowski DJ, Yu JJ, Henske EP.

Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12455-60. doi: 10.1073/pnas.1104361108. Epub 2011 Jul 11.

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