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Items: 1 to 20 of 89

1.

Widespread somatic L1 retrotransposition occurs early during gastrointestinal cancer evolution.

Ewing AD, Gacita A, Wood LD, Ma F, Xing D, Kim MS, Manda SS, Abril G, Pereira G, Makohon-Moore A, Looijenga LH, Gillis AJ, Hruban RH, Anders RA, Romans KE, Pandey A, Iacobuzio-Donahue CA, Vogelstein B, Kinzler KW, Kazazian HH Jr, Solyom S.

Genome Res. 2015 Oct;25(10):1536-45. doi: 10.1101/gr.196238.115. Epub 2015 Aug 10.

2.

Immune signatures correlate with L1 retrotransposition in gastrointestinal cancers.

Jung H, Choi JK, Lee EA.

Genome Res. 2018 Aug;28(8):1136-1146. doi: 10.1101/gr.231837.117. Epub 2018 Jul 3.

3.

Extensive somatic L1 retrotransposition in colorectal tumors.

Solyom S, Ewing AD, Rahrmann EP, Doucet T, Nelson HH, Burns MB, Harris RS, Sigmon DF, Casella A, Erlanger B, Wheelan S, Upton KR, Shukla R, Faulkner GJ, Largaespada DA, Kazazian HH Jr.

Genome Res. 2012 Dec;22(12):2328-38. doi: 10.1101/gr.145235.112. Epub 2012 Sep 11.

4.

Somatically Acquired LINE-1 Insertions in Normal Esophagus Undergo Clonal Expansion in Esophageal Squamous Cell Carcinoma.

Doucet-O'Hare TT, Sharma R, Rodić N, Anders RA, Burns KH, Kazazian HH Jr.

Hum Mutat. 2016 Sep;37(9):942-54. doi: 10.1002/humu.23027. Epub 2016 Jul 13.

5.

Landscape of somatic retrotransposition in human cancers.

Lee E, Iskow R, Yang L, Gokcumen O, Haseley P, Luquette LJ 3rd, Lohr JG, Harris CC, Ding L, Wilson RK, Wheeler DA, Gibbs RA, Kucherlapati R, Lee C, Kharchenko PV, Park PJ; Cancer Genome Atlas Research Network.

Science. 2012 Aug 24;337(6097):967-71. doi: 10.1126/science.1222077. Epub 2012 Jun 28.

6.

The Role of Somatic L1 Retrotransposition in Human Cancers.

Scott EC, Devine SE.

Viruses. 2017 May 31;9(6). pii: E131. doi: 10.3390/v9060131. Review.

7.

L1 retrotransposition is a common feature of mammalian hepatocarcinogenesis.

Schauer SN, Carreira PE, Shukla R, Gerhardt DJ, Gerdes P, Sanchez-Luque FJ, Nicoli P, Kindlova M, Ghisletti S, Santos AD, Rapoud D, Samuel D, Faivre J, Ewing AD, Richardson SR, Faulkner GJ.

Genome Res. 2018 May;28(5):639-653. doi: 10.1101/gr.226993.117. Epub 2018 Apr 11.

8.

Deep sequencing reveals low incidence of endogenous LINE-1 retrotransposition in human induced pluripotent stem cells.

Arokium H, Kamata M, Kim S, Kim N, Liang M, Presson AP, Chen IS.

PLoS One. 2014 Oct 7;9(10):e108682. doi: 10.1371/journal.pone.0108682. eCollection 2014.

9.

Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes.

Tubio JMC, Li Y, Ju YS, Martincorena I, Cooke SL, Tojo M, Gundem G, Pipinikas CP, Zamora J, Raine K, Menzies A, Roman-Garcia P, Fullam A, Gerstung M, Shlien A, Tarpey PS, Papaemmanuil E, Knappskog S, Van Loo P, Ramakrishna M, Davies HR, Marshall J, Wedge DC, Teague JW, Butler AP, Nik-Zainal S, Alexandrov L, Behjati S, Yates LR, Bolli N, Mudie L, Hardy C, Martin S, McLaren S, O'Meara S, Anderson E, Maddison M, Gamble S, Foster C, Warren AY, Whitaker H, Brewer D, Eeles R, Cooper C, Neal D, Lynch AG, Visakorpi T, Isaacs WB, Veer LV, Caldas C, Desmedt C, Sotiriou C, Aparicio S, Foekens JA, Eyfjörd JE, Lakhani SR, Thomas G, Myklebost O, Span PN, Børresen-Dale AL, Richardson AL, Van de Vijver M, Vincent-Salomon A, Van den Eynden GG, Flanagan AM, Futreal PA, Janes SM, Bova GS, Stratton MR, McDermott U, Campbell PJ; ICGC Breast Cancer Group; ICGC Bone Cancer Group; ICGC Prostate Cancer Group.

Science. 2014 Aug 1;345(6196):1251343. doi: 10.1126/science.1251343.

10.

A hot L1 retrotransposon evades somatic repression and initiates human colorectal cancer.

Scott EC, Gardner EJ, Masood A, Chuang NT, Vertino PM, Devine SE.

Genome Res. 2016 Jun;26(6):745-55. doi: 10.1101/gr.201814.115. Epub 2016 May 10.

11.

Involvement of retrotransposition of long interspersed nucleotide element-1 in skin tumorigenesis induced by 7,12-dimethylbenz[a]anthracene and 12-O-tetradecanoylphorbol-13-acetate.

Okudaira N, Goto M, Yanobu-Takanashi R, Tamura M, An A, Abe Y, Kano S, Hagiwara S, Ishizaka Y, Okamura T.

Cancer Sci. 2011 Nov;102(11):2000-6. doi: 10.1111/j.1349-7006.2011.02060.x. Epub 2011 Sep 19.

12.

Long Interspersed Element Sequencing (L1-Seq): A Method to Identify Somatic LINE-1 Insertions in the Human Genome.

Doucet TT, Kazazian HH Jr.

Methods Mol Biol. 2016;1400:79-93. doi: 10.1007/978-1-4939-3372-3_5.

13.
14.

Elevated expression of Bcl-X and reduced Bak in primary colorectal adenocarcinomas.

Krajewska M, Moss SF, Krajewski S, Song K, Holt PR, Reed JC.

Cancer Res. 1996 May 15;56(10):2422-7.

15.

Genomic characterization of recent human LINE-1 insertions: evidence supporting random insertion.

Ovchinnikov I, Troxel AB, Swergold GD.

Genome Res. 2001 Dec;11(12):2050-8.

16.

L1 hybridization enrichment: a method for directly accessing de novo L1 insertions in the human germline.

Freeman P, Macfarlane C, Collier P, Jeffreys AJ, Badge RM.

Hum Mutat. 2011 Aug;32(8):978-88. doi: 10.1002/humu.21533. Epub 2011 Jul 12.

17.

L1 integration in a transgenic mouse model.

Babushok DV, Ostertag EM, Courtney CE, Choi JM, Kazazian HH Jr.

Genome Res. 2006 Feb;16(2):240-50. Epub 2005 Dec 19.

18.

LINE-1 retrotransposition in the nervous system.

Thomas CA, Paquola AC, Muotri AR.

Annu Rev Cell Dev Biol. 2012;28:555-73. doi: 10.1146/annurev-cellbio-101011-155822. Review.

PMID:
23057747
19.

Active retrotransposition by a synthetic L1 element in mice.

An W, Han JS, Wheelan SJ, Davis ES, Coombes CE, Ye P, Triplett C, Boeke JD.

Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18662-7. Epub 2006 Nov 21.

20.

Endogenous retrotransposition activates oncogenic pathways in hepatocellular carcinoma.

Shukla R, Upton KR, Muñoz-Lopez M, Gerhardt DJ, Fisher ME, Nguyen T, Brennan PM, Baillie JK, Collino A, Ghisletti S, Sinha S, Iannelli F, Radaelli E, Dos Santos A, Rapoud D, Guettier C, Samuel D, Natoli G, Carninci P, Ciccarelli FD, Garcia-Perez JL, Faivre J, Faulkner GJ.

Cell. 2013 Mar 28;153(1):101-11. doi: 10.1016/j.cell.2013.02.032.

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